Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation [PDF]
Journal of Animal Science and BiotechnologyBackground Early embryo loss is an important factor affecting the reproductive capacity of cattle. Recent studies have revealed that during the process of embryonic genome activation (EGA), epigenetic modification, such as histone lactylation remodeling,
Wenjie Yu +10 more
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Histone lactylation: A new epigenetic mark in the malaria parasite Plasmodium. [PDF]
PLoS GenetEpigenetic processes play important roles in the biology of the malaria parasite Plasmodium falciparum. Here, we characterised a new epigenetic mark, histone lactylation, for the first time in Plasmodium: it was found in two human malaria parasites, P ...
Jabre I +9 more
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Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration [PDF]
iScienceSummary: Tissue regeneration relies on precise molecular mechanisms controlling cell-fate transitions, with metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an epigenetic modification regulating ...
Jorge Borbinha +6 more
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Metabolic regulation of gene expression by histone lactylation [PDF]
Nature, 2019 The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells. This phenomenon is intimately linked to several diseases including neoplasia, sepsis and autoimmune diseases1,2.
Di Zhang, He Huang, Sunjoo Kim
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Histone lactylation-driven feedback loop modulates pyrimidine metabolism to promote oral carcinogenesis [PDF]
Cell Death and DiseaseMetabolic reprogramming and epigenetic alterations promote oral squamous cell carcinoma (OSCC). Lactate-dependent histone modification is a novel histone mark that connects the epigenetic process of lactylation to glycolytic metabolites.
Yanting Wang +8 more
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Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.
PLoS ONE, 2023 Lactate, which is synthesized as an end product by lactate dehydrogenase A (LDHA) from pyruvate during anaerobic glycolysis, has attracted attention for its energy metabolism and oxidant effects.
Erika Minami +7 more
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Genome Biology, 2021 Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu +6 more
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Research progress and prospect of histone lactylation in digestive system tumors [PDF]
Zhongguo aizheng zazhiHistone lactylation is a novel type of post-translational modification, where a lactate molecule covalently binds to the lysine residues of histones. This modification plays a key role in cellular metabolic reprogramming, particularly in digestive system
ZENG Dandan, LUO Wenfeng, YE Jiazhou, LIN Yan, LIANG Rong
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Histone lactylation in macrophages is predictive for gene expression changes during ischemia induced-muscle regeneration [PDF]
Molecular MetabolismObjectives: We have previously shown that lactate is an essential metabolite for macrophage polarisation during ischemia-induced muscle regeneration. Recent in vitro work has implicated histone lactylation, a direct derivative of lactate, in macrophage ...
Thibaut Desgeorges +4 more
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Fusobacterium nucleatum promotes tumor progression driven by histone lactylation through increasing GLUT1 expression in colorectal cancer [PDF]
Journal of Translational MedicineBackground The gut microbiota plays a significant role in the incidence and progression of colorectal cancer（CRC）, with Fusobacterium nucleatum (F. nucleatum) identified as a contributor to the advancement of this malignancy.
Shizhen Zhou +9 more
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