Results 11 to 20 of about 4,116 (175)

Lactate metabolic reprogramming and histone lactylation modification in sepsis. [PDF]

Int J Biol Sci
Sepsis, a serious condition characterized by life-threatening organ dysfunction owing to infection, lacks specific therapeutic interventions. Lactate serves as a crucial biomarker in sepsis, reflecting both the patient's metabolic state and the severity of the condition.
Zhang J, Wu D, Zeng F, Gu H, Li C, Cata JP, Guo K, Miao C, Zhang H.   +8 more
europepmc   +4 more sources

Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis

Cell Metabolism
Histone lysine lactylation is a physiologically and pathologically relevant epigenetic pathway that can be stimulated by the Warburg effect-associated L-lactate. Nevertheless, the mechanism by which cells use L-lactate to generate lactyl-coenzyme A (CoA) and how this process is regulated remains unknown.
Yingming Zhao, Ruilong Liu, Xuelian Ren   +2 more
exaly   +4 more sources

Histone H3K18 and Ezrin Lactylation Promote Renal Dysfunction in Sepsis‐Associated Acute Kidney Injury

Advanced Science
Histone lactylation is a metabolic stress‐related histone modification. However, the role of histone lactylation in the development of sepsis‐associated acute kidney injury (SA‐AKI) remains unclear.
Jiao Qiao, Yuan Tan, Hongchao Liu, Boxin Yang, Qian Zhang, Qi Liu, Wenyuan Sun, Zhongxin Li, Qingchen Wang, Weimin Feng, Shuo Yang, Liyan Cui   +11 more
doaj   +2 more sources

Fusobacterium nucleatum promotes tumor progression driven by histone lactylation through increasing GLUT1 expression in colorectal cancer [PDF]

Journal of Translational Medicine
Background The gut microbiota plays a significant role in the incidence and progression of colorectal cancer（CRC）, with Fusobacterium nucleatum (F. nucleatum) identified as a contributor to the advancement of this malignancy.
Shizhen Zhou, Kai Wang, Hao Wang, Qinggang Yuan, Xinxin Yu, Lei Li, Linsen Shi, Qiongyuan Hu, Lixiang Liu, Chao Ding   +9 more
doaj   +2 more sources

Histone lactylation: A new epigenetic mark in the malaria parasite Plasmodium. [PDF]

PLoS Genet
ABSTRACT Epigenetic processes play important roles in the biology of the malaria parasite Plasmodium falciparum . Here, we characterised a new epigenetic mark, histone lactylation, recently discovered in humans: it was found in two human malaria parasites, P ...
Jabre I, Andoh NE, Naldoni J, Gregory W, Mbye H, Yoon CE, Cunnington AJ, Georgiadou A, Blagborough AM, Merrick CJ.   +9 more
europepmc   +4 more sources

Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications [PDF]

Drug Design, Development and Therapy
Yuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street ...
Qiu Y, Shao X
doaj   +2 more sources

Non-histone lactylation: unveiling its functional significance

Frontiers in Cell and Developmental Biology
Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have increasingly demonstrated its widespread presence on non-histone proteins. Recently, high-throughput proteomics studies have identified a large number of
Yongjie Ma
exaly   +4 more sources

DPF2 reads histone lactylation to drive transcription and tumorigenesis

Proceedings of the National Academy of Sciences of the United States of America
Lysine lactylation (Kla) is a new type of histone mark implicated in the regulation of various functional processes such as transcription. However, how this histone mark acts in cancers remains unexplored due in part to a lack of knowledge about its reader proteins.
Kai Zhang, Aiyuan Wang
exaly   +3 more sources

Women with polycystic ovary syndrome exhibit impaired endometrial receptivity with excessive ERα and histone lactylation [PDF]

Nature Communications
Polycystic ovary syndrome (PCOS) is one of the most common reproductive disorders in women and severely impairs fertility. Extant clinical studies can only provide indirect and plausible evidence to support endometrial dysfunction as an ovary-independent
Hongying Shan, Yue Wang, Baoying Liao, Kai-Lun Hu, Xiunan Chen, Chenxi Xiao, Zi Yang, Fenting Liu, Tianliu Peng, Mingmei Lin, Feng Deng, Ping Zhou, Yang Yu, Rong Li, Heng Pan   +14 more
doaj   +2 more sources

Histone lactylation: A new frontier in laryngeal cancer research (Review). [PDF]

Oncol Lett
Laryngeal cancer is a common malignant tumor of the head and neck, and its occurrence and development are closely related to epigenetic modifications. Histone lactylation, a novel form of epigenetic modification, regulates gene expression and is involved in processes such as tumor metabolic reprogramming, shaping the tumor microenvironment, maintaining
Tong Q, Huang C, Tong Q, Zhang Z.
europepmc   +3 more sources