Results 11 to 20 of about 128,524 (232)

Metabolic reprogramming regulates histone lactylation during zebrafish caudal fin regeneration [PDF]

iScience
Summary: Tissue regeneration relies on precise molecular mechanisms controlling cell-fate transitions, with metabolism emerging as a key regulator. Lactate-derived histone lactylation has recently been identified as an epigenetic modification regulating ...
Jorge Borbinha, Raquel Lourenço, Ana S. Brandão, Daniel Ribeiro, Ana Carvalho, Rune Matthiesen, António Jacinto   +6 more
doaj   +3 more sources

Histone lactylation: a new epigenetic mark in the malaria parasite Plasmodium [PDF]

PLOS Genetics
ABSTRACT Epigenetic processes play important roles in the biology of the malaria parasite Plasmodium falciparum . Here, we characterised a new epigenetic mark, histone lactylation, recently discovered in humans: it was found in two human malaria parasites, P ...
Ibtissam Jabre, Nana Efua Andoh, Juliana Naldoni, William Gregory, Haddijatou Mbye, Chae Eun Yoon, Aubrey J. Cunnington, Athina Georgiadou, Andrew M. Blagborough, Catherine J. Merrick   +9 more
core   +26 more sources

Lactate-induced histone lactylation by p300 promotes osteoblast differentiation.

PLoS ONE, 2023
Lactate, which is synthesized as an end product by lactate dehydrogenase A (LDHA) from pyruvate during anaerobic glycolysis, has attracted attention for its energy metabolism and oxidant effects.
Erika Minami, Kiyohito Sasa, Atsushi Yamada, Ryota Kawai, Hiroshi Yoshida, Haruhisa Nakano, Koutaro Maki, Ryutaro Kamijo   +7 more
doaj   +2 more sources

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated-Acute Kidney Injury. [PDF]

Adv Sci (Weinh)
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Liang H, Jiang J, Yin H, Liu C, Huang H, Luo Y, Zhu M, Wang Q.   +7 more
europepmc   +2 more sources

Research progress and prospect of histone lactylation in digestive system tumors [PDF]

Zhongguo aizheng zazhi
Histone lactylation is a novel type of post-translational modification, where a lactate molecule covalently binds to the lysine residues of histones. This modification plays a key role in cellular metabolic reprogramming, particularly in digestive system
ZENG Dandan, LUO Wenfeng, YE Jiazhou, LIN Yan, LIANG Rong
doaj   +5 more sources

Re-evaluating the mechanism of histone lactylation

, 2020
Recent work by Zhang et al. published in Nature identified a unique non-metabolic role of the glycolysis end-product lactate, in post-translational lactylation of histones. The original study as well as follow-up editorials allude that lactate after being activated as lactyl-CoA mediates histone lactylation.
Sunada Khadka, Yasaman Barekatain, Florian Muller   +2 more
openaire   +3 more sources

Lysine lactylation in diseases: beyond histone lactylation [PDF]

Cell Death & Disease
Abstract Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms. Elevated intracellular lactate has been shown to drive histone lysine lactylation (Kla), establishing its association ...
Yiming Liu, Xuan Guo, Xinyang Hu, Sining Zhou, Qi Yang, Pingping Feng, Linghui Zeng   +6 more
openaire   +3 more sources

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging‐Related Pathways

Advanced Science
Epigenetic alterations are among the prominent drivers of cellular senescence and/or aging, intricately orchestrating gene expression programs during these processes.
Fanju Meng, Jianuo He, Xuebin Zhang, Wencong Lyu, Ran Wei, Shiyi Wang, Zhehao Du, Haochen Wang, Jinlong Bi, Xueyang Hua, Chao Zhang, Yiting Guan, Guoliang Lyu, Xiao‐Li Tian, Lijun Zhang, Wenbing Xie, Wei Tao   +16 more
doaj   +2 more sources

Chrysanthemum Morifolium-Derived Nanovesicles Reduce Lactate-Associated Histone Lactylation and Modulate Microglia-Mediated Neuroinflammation in Sepsis-Associated Encephalopathy. [PDF]

Adv Sci (Weinh)
When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Li K, Luo X, Zhang X, He C, Xu W, Xu A, Hua S, Wang L, Ma L, Hao K, Ying Y, Wang Z.   +11 more
europepmc   +2 more sources

Non-histone lactylation in cancer: current advances and clinical implications [PDF]

Frontiers in Immunology
Lactylation, a novel post-translational modification characterized by the covalent attachment of lactate to specific lysine residues, has emerged as a critical metabolic regulator in cancer.
Robert Le Yang, Yiran Liang
doaj   +2 more sources