Results 31 to 40 of about 5,991 (236)

Identification of lactylation related model to predict prognostic, tumor infiltrating immunocytes and response of immunotherapy in gastric cancer

Frontiers in Immunology, 2023
BackgroundThe epigenetic regulatory chemical lactate is a product of glycolysis. It can regulate gene expression through histone lactylation, thereby promoting tumor proliferation, metastasis, and immunosuppression.MethodsIn this study, a lactylation ...
Hao Yang, Xiaoming Zou, Shifeng Yang, Ange Zhang, Nana Li, Zhen Ma   +5 more
doaj   +1 more source

Lactate:A key regulator of the immune response [PDF]

Lactate, the end product of both anaerobic and aerobic glycolysis in proliferating and growing cells-with the latter process known as the Warburg effect-is historically considered a mere waste product of cell and tissue metabolism. However, research over
Certo, Michelangelo, Gope, Atrayee, Kucuk, Salih, Llibre, Alba, Mauro, Claudio   +4 more
core   +1 more source

The expanding constellation of histone post-translational modifications in the epigenetic landscape [PDF]

, 2021
The emergence of a nucleosome-based chromatin structure accompanied the evolutionary transition from prokaryotes to eukaryotes. In this scenario, histones became the heart of the complex and precisely timed coordination between chromatin architecture and
Cavalieri V.
core   +1 more source

Predicting lymphoma prognosis using machine learning-based genes associated with lactylation

Translational Oncology
Background: Lactylation, a newly discovered PTM involving lactic acid, is linked to solid tumor proliferation and metastasis. Lymphoma patients exhibit high lactic acid levels, yet lactylation's role in lymphoma is underexplored.
Miao Zhu, Qin Xiao, Xinzhen Cai, Zhiyue Chen, Qingqing Shi, Xing Sun, Xiaoyan Xie, Mei Sun   +7 more
doaj   +1 more source

Histone lactylation: a new epigenetic mark in the malaria parasite Plasmodium [PDF]

Epigenetic processes play important roles in the biology of the malaria parasite Plasmodium falciparum. Here, we characterised a new epigenetic mark, histone lactylation, for the first time in Plasmodium: it was found in two human malaria parasites, P ...

core   +2 more sources

Gut Lactate Boosts Ruminococcus via Histone Lactylation to Mediate Time‐Restricted Feeding Protection in Crohn's Disease

Advanced Science, EarlyView.
TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang, Huishi Tan, Senhui Weng, Yuntao Liu, Lingxu Song, Shaoyu Cheng, Zelong Lin, Jiawei Chen, Fei Tan, Jun Wang, Jinke Huang, Linkun Cai, Jiwei Chai, Cailing Zhong, Yanqiang Shi, Wendi Zhang, Haiyan Zhang, Chongyang Huang   +17 more
wiley   +1 more source

Lactylation in cancer: Mechanisms in tumour biology and therapeutic potentials

Clinical and Translational Medicine
Lactylation, a recently identified form of protein post‐translational modification (PTM), has emerged as a key player in cancer biology. The Warburg effect, a hallmark of tumour metabolism, underscores the significance of lactylation in cancer ...
Yipeng He, Tianbao Song, Jinzhuo Ning, Zefeng Wang, Zhen Yin, Pengcheng Jiang, Qin Yuan, Weimin Yu, Fan Cheng   +8 more
doaj   +1 more source

Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges

Journal of Advanced Research
Background: Lactate was once considered as metabolic waste for a long time. In 2019, Professor Zhao Yingming’s team from the University of Chicago found that lactate could also be used as a substrate to induce histone lactylation and regulate gene ...
Xue-ting Hu, Xiao-feng Wu, Jin-yi Xu, Xiang Xu   +3 more
doaj   +1 more source

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Lysine lactylation in diseases: beyond histone lactylation

Cell Death & Disease
Abstract Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms. Elevated intracellular lactate has been shown to drive histone lysine lactylation (Kla), establishing its association ...
Yiming Liu, Xuan Guo, Xinyang Hu, Sining Zhou, Qi Yang, Pingping Feng, Linghui Zeng   +6 more
openaire   +1 more source