Results 11 to 20 of about 7,170 (205)

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation. [PDF]

Adv Sci (Weinh)
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Tian Y, Ma S, Yang B, Gao F, Guo H, Liu H, Wu X, Cui W, Dong J, Lin Q, Ge Y, Ma J, Zhao J, Zhang Y, Xue D, Tian J, Zhang Z, Wang K, Xu M, Feng D, Zhou J, Qu Y.   +21 more
europepmc   +2 more sources

AARS2-SIRT5-Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells. [PDF]

Adv Sci (Weinh)
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Ding M, Xu H, Liu C, Ding Y, Wang S, Yin J, Fu T, Jiang X, Chen Y, Luo H, Li R, Chen Z, Wang H.   +12 more
europepmc   +2 more sources

A Metabolic-Epigenetic Axis of AARS1/IGF2BP3-K280 Lactylation Sustains Endometrial Cancer Stemness and Recurrence. [PDF]

Adv Sci (Weinh)
Lactate‐driven endometrial cancer relapse is mediated by enzymatic protein modification. Elevated lactate levels activate AARS1, which catalyzes K280 lactylation of IGF2BP3, therefore stabilizing HMGA2 mRNA and promoting tumor stemness and recurrence.
Jiang P, Zheng Y, Tian C, Tu Y, Chang X, Yu J, Yu H, Gong C, Xiong J, Baker PN, Fu Y, Tong C.   +11 more
europepmc   +2 more sources

ACAT1-Mediated SP1-K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD. [PDF]

Adv Sci (Weinh)
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Lin L, Zhang P, Song Q, Li T, Zeng Y, Chen P.   +5 more
europepmc   +2 more sources

Tip60-Mediated USP22 Lactylation Drives Glutamine Metabolic Reprogramming via SLC25A5 in TNBC. [PDF]

Adv Sci (Weinh)
Tip60‐mediated USP22 K134 lactylation, stabilizing SLC25A5 to enhance glutamine metabolism and α‐KG secretion. The secreted α‐KG drives GPR91‐dependent M2 macrophage polarization, promoting triple‐negative breast cancer progression. Targeting this axis synergizes with CB‐839, offering a promising therapeutic strategy for TNBC.
Zhen F, Wang H, Zhang N, Wang L, Tian H, Kang L, Liu Z, Hu J.   +7 more
europepmc   +2 more sources

HADHA ^K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer. [PDF]

Adv Sci (Weinh)
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Feng M, Jiao Q, Zhu J, Ren Y, Teng X, Su X, Li Z, Cai Y, Liu X, Wang Y, Zhang G.   +10 more
europepmc   +2 more sources

Lactate Signal: Modulator of Cellular Energy Production and Anabolism [PDF]

Advanced science
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Wang H, Yang S, Xu W.
europepmc   +2 more sources

Lactylation‐Mediated HER2 Stabilization Promotes Trastuzumab Resistance in Gastric Cancer [PDF]

Advanced science
Warburg effect‐derived lactate drives HER2 lactylation and trastuzumab resistance. Mechanistically, AARS1‐mediated lactylation stabilizes HER2 by inhibiting USP11‐dependent degradation and concurrently promotes HER2‐EGFR interaction. Importantly, inhibiting HER2 lactylation resensitizes gastric cancer cells to trastuzumab.
Qian M, Tian T, Wang Z, Sun H, Zong M, Chen Y, Xiong J, Chen Y, Hu Z, Li T, Xu Y, Xu S.   +11 more
europepmc   +2 more sources

Lysine lactylation in diseases: beyond histone lactylation

Cell Death & Disease
Abstract Lactylation, a recently identified post-translational modification, was initially characterized as lysine residue modification in histone subunits that regulates gene transcription via epigenetic mechanisms. Elevated intracellular lactate has been shown to drive histone lysine lactylation (Kla), establishing its association ...
Yiming Liu, Xuan Guo, Xinyang Hu, Sining Zhou, Qi Yang, Pingping Feng, Linghui Zeng   +6 more
openaire   +2 more sources

Über Lactyl‐p‐aminobenzoesäure [PDF]

Berichte der deutschen chemischen Gesellschaft, 1917
n ...
openaire   +2 more sources