Results 61 to 70 of about 7,170 (205)

Characterization of protein lactylation in healthy and ischemic mouse hearts

Frontiers in Cardiovascular Medicine
BackgroundRecent findings highlight the growing importance of protein lactylation, a modification driven by lactate, in healthy and diseased states. However, its significance in myocardial infarction (MI) remains unclear.
Daiqian Wu, Yuanjuan Tang, Xingbing Li, Shiqiang Xiong, Zhen Zhang, Jinjuan Fu   +5 more
doaj   +1 more source

Multi-omics analysis of the HMGB2+ tumor epithelial cells in lactylation subgroups in colorectal cancer

Cell & Bioscience
Colorectal cancer (CRC) is a prevalent malignancy, yet the role of lactylation in its progression remains unclear. This study investigates High Mobility Group Box 2 positive tumor epithelial cells (HMGB2+Epi), a lactylation-associated subpopulation.
Shangshang Hu, Jinwei Lou, Muzi Ding, Yuhan Chen, Jian Qin, Zixuan Liu, Yue Li, QianNi Xiao, Mu Xu, Huiling Sun, Yuqin Pan, Shukui Wang   +11 more
doaj   +1 more source

Lactylation: The emerging frontier in post-translational modification

Frontiers in Genetics
Lactate, a metabolic byproduct, has gained recognition as a highly influential signaling molecule. Lactylation, an emerging form of post-translational modification derived from lactate, plays a crucial role in numerous cellular processes such as ...
Zhou Lu, Xueting Zheng, Mingsong Shi, Yuan Yin, Yuanyuan Liang, Zhiyan Zou, Chenghe Ding, Yuanjing He, Yan Zhou, Xiaoan Li, Xiaoan Li   +10 more
doaj   +1 more source

Exploring the mechanisms of mutual influence between lactylation and macrophage polarization in the context of disease

Clinical and Translational Medicine
Background Lactylation, a post‐translational alteration facilitated by lactic acidderived lactyl‐CoA, has emerged as an epigenetic regulator that alters gene expression in macrophages. Emerging data situates lactylation at the nexus of metabolic flux and
Houhua Guo, Nannan Luan, Jian Gao, Xiaoao Pang, Jianlei Bi, Liancheng Zhu   +5 more
doaj   +1 more source

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

Advanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao, Jianzhong Cao, Wenyue Liu, Xuyun Li, Haolin Zhang, Xiaofang Zhang, Shiyang Shi, Huilong Yin, Junjie Li, Angang Yang, Rui Zhang   +10 more
wiley   +1 more source

Lactate-driven lactylation of HNRNPA1 orchestrates PKM2 splicing and glycolytic reprogramming in bladder cancer

Journal of Experimental & Clinical Cancer Research
Background Lactylation, a recently identified post-translational modification derived from lactate, has emerged as a regulator of tumor metabolism. However, its functional relevance and molecular targets in bladder cancer (BLCA) remain unclear.
Tianqi Wang, Xiaohong Ma, Yini Wang, Hongquan Liu, Guixin Ding, Yanfei Li, Hejia Yuan, Jie Gao, Fengze Sun, Yicheng Guo, Jian Ma, Jitao Wu   +11 more
doaj   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease [PDF]

Advanced science
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Liu Y, Li X, He W, Li F, Ou Q, Liu Y, Lei J, Bao Y, Huang H, Feng W, Tang Y, Qiu X, Gan L, Shen Y, Wang J, Xiao Y.   +15 more
europepmc   +2 more sources

Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia

Frontiers in Neurology
BackgroundVascular dementia (VD) is the only preventable form of dementia-related disease. Electroacupuncture (EA) has been shown to provide significant benefits in the treatment of VD.
Yinghua Chen, Wei Sun, Wei Sun, Zhongren Sun, Hongxu Zhao, Tong Wu, Yuanyu Song, Haoyu Wang, Haoyu Wang, Ruiqi Qin, Xiaoqing Su, Junfeng Li, Junfeng Li, Yue Miao, Xinran Li, Lin Wu   +15 more
doaj   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Chrysanthemum Morifolium–Derived Nanovesicles Reduce Lactate‐Associated Histone Lactylation and Modulate Microglia‐Mediated Neuroinflammation in Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
When used to treat sepsis‐associated encephalopathy, Chrysanthemum morifolium–derived nanovesicles can inhibit the H3K18la/NF‐κB axis to regulate microglia‐mediated neuroinflammation. ABSTRACT Sepsis‐associated encephalopathy (SAE)—a complication of the central nervous system in patients with sepsis—markedly diminishes cognitive functions and is linked
Kaiqiang Li, Xuling Luo, Xiaoting Zhang, Chengwen He, Wei Xu, Aibo Xu, Shushan Hua, Liping Wang, Liang Ma, Ke Hao, Youmin Ying, Zhen Wang   +11 more
wiley   +1 more source