Results 71 to 80 of about 5,991 (236)
N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential
iNew Medicine, EarlyView.ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen +6 more
wiley +1 more source
Protein Lactylation: A new jewel in the crown
Asian Journal of Medical SciencesLactylation is a newly identified post-translational modification that has emerged as a crucial epigenetic regulator, significantly influencing cellular functions and disease processes. Lactylation involves the addition of lactate, a glycolysis byproduct,
Ruby Dhar +2 more
doaj +1 more source
Metabolic-epigenetic regulation of macrophage polarization. [PDF]
, 2021 Tumor-associated macrophages polarized to an M2 phenotype (M2-TAMs) promote neo-angiogenesis, tumor-stromal matrix remodeling, and immuno-evasion, which, collectively, contribute to immunotherapeutic resistance and reduced cancer patient survival. Highly
Noe, Jordan T.
core +1 more source
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Exploring the link between environmental chemical exposures and epigenetic modifications in diabetes mellitus [PDF]
Diabetes mellitus (DM) is a globally prevalent metabolic disorder characterized by impaired glucose homeostasis and insulin secretion. Beyond traditional risk factors like lifestyle and genetics, environmental pollutants, including particulate matter ...
Abunada, Hanan H. +5 more
core +2 more sources
KAT2A Promotes the Progression of Renal Cell Carcinoma by Regulating the Succinylation of SERPINE2
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Epithelial‐mesenchymal transition (EMT) and angiogenesis are critical drivers of renal cell carcinoma (RCC) progression, yet their upstream regulatory mechanisms remain incompletely understood. This study aimed to investigate the role of KAT2A in RCC and elucidate the underlying molecular mechanism by which it promotes tumor progression.
Chang‐Cheng Liu, Xue‐Dong Li
wiley +1 more source
Beyond IDO1: Systems-Level Insights Into Enzymatic Networks And Regulatory Mechanisms In Cancer Immunotherapy Resistance [PDF]
Background: Cancer immunotherapy resistance affects 60-80% of patients receiving immune checkpoint inhibitors. The failure of IDO1 inhibitors in ECHO-301—despite achieving >90% target engagement—revealed critical gaps in understanding ...
Meera Indracanti, Muni Kumar Dokka, Madhumita Panda, Padmaja Musunuri, Nagendra Babu Gundamraju
core +2 more sources
Phytotherapy Research, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo +3 more
wiley +1 more source
Advanced ScienceEpigenetic alterations are among the prominent drivers of cellular senescence and/or aging, intricately orchestrating gene expression programs during these processes.
Fanju Meng +16 more
doaj +1 more source
Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia
Frontiers in NeurologyBackgroundVascular dementia (VD) is the only preventable form of dementia-related disease. Electroacupuncture (EA) has been shown to provide significant benefits in the treatment of VD.
Yinghua Chen +15 more
doaj +1 more source