Results 91 to 100 of about 7,170 (205)

Lactylation in influenza a virus infection: Current evidence, knowledge gaps, and future perspectives

Virulence
Influenza A virus (IAV) is a major respiratory pathogen causing seasonal epidemics and pandemics, posing serious threats to public health and livestock.
Yu-Mei Chen Yan, Zhijun Li, Haiyan He, Moding Wu, Haolin Yang, Fanhua Wei   +5 more
doaj   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Lactylation in pulmonary fibrosis: current understanding and challenges

Journal of Translational Medicine
Background Pulmonary fibrosis (PF) is a progressive, chronic lung disease, which is accompanied by epithelial cell damage, fibroblast activation, and macrophage polarization; the fibrotic niche is primarily composed of these three cell types.
Bo Li, Xiao-hong Li, Yan Zhou, Dan-dan Feng, Zi-qiang Luo, Hai-peng Cheng   +5 more
doaj   +1 more source

Lactylation and Central Nervous System Diseases

Brain Sciences
As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases and mediates lactylation, an epigenetic modification that occurs under both physiological and pathological conditions ...
Ye Chen, Dongqiong Xiao, Xihong Li
doaj   +1 more source

Chronic high‐altitude exposure and intracerebral hemorrhage: A novel perspective from the vascular‐immune‐neuronal network

Neuroprotection, EarlyView.
Long‐term chronic high‐altitude hypobaric hypoxia increases susceptibility to ICH, particularly among migrant populations lacking EPAS1/SENP1 adaptive genetic variants relative to high‐altitude indigenous residents. Persistent hypoxia initiates blood–brain barrier (BBB) breakdown, aberrant glial and immune activation, and progressive neuronal injury ...
Rongsu Huang, Linjie Wei, Mingxi Li, Bo Wu, Rongjian Ouyang, Gang Zhu, Yujie Chen   +6 more
wiley   +1 more source

CAFs‐mediated histone lactylation reprograms cholesterol metabolism in colorectal cancer to drive CD8+ T cell immunosuppression

The Journal of Pathology, EarlyView.
Abstract The progression of colorectal cancer (CRC) is critically regulated by cancer‐associated fibroblasts (CAFs) within the tumor microenvironment (TME), yet the specific molecular mechanisms by which CAFs influence CRC remain unclear. This study reveals the mechanism by which CAFs promote CRC malignant progression and immune suppression through ...
Huachi Li, Jun Hu, Lei Huang, Zihao Wang, Haoran Tao, Feng Cao, Min Xie   +6 more
wiley   +1 more source

Progress of Research on the Metabolic Regulation of Lactylation in Muscle Tissues and Its Disease Associations

Biomolecules
Lactylation serves as a vital link between cellular metabolism and epigenetic regulation and plays a pivotal role in muscle biology. Muscle tissue is the primary site of lactate production; its unique metabolic environment confers dynamism, specificity ...
Zhihang Wang, Ji Zhang, Junxi Wu, Guangrun Liu, Yun He, Hongbo Zhao, Xiaolin Jiang, Shengbo Yang   +7 more
doaj   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

[Role and Mechanism of Lactylation in Cancer].

Zhongguo fei ai za zhi = Chinese journal of lung cancer
Post translational modifications (PTMs) can change the properties of a protein by covalent addition of functional groups to one or more amino acids, and influence almost all aspects of normal cell biology and pathogenesis. Lactylation is a novel identified PTM, and has been found in both histone and non-histone proteins.
Qicheng ZHANG, Limin CAO, Ke XU
openaire   +2 more sources

H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer

Journal of Experimental & Clinical Cancer Research
Abstract Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown.
Liu, Jiena, Zhao, Liuying, Yan, Meisi, Jin, Shengye, Shang, Lingmin, Wang, Jianyu, Wang, Qin, Zhao, Shilu, Shen, Zibo, Liu, Tong, Wu, Hao, Pang, Da   +11 more
openaire   +2 more sources