Results 91 to 100 of about 5,991 (236)

Lactylation’s role in bone health and disease: mechanistic insights and therapeutic potential [PDF]

PeerJ
This article reviews the mechanisms and research progress of lactylation, an emerging post-translational modification (PTM) of proteins, in bone metabolism and related diseases.
Zhiyuan Ye, Xuanyu Chen, Jiyuan Zou, Wenjing Wu, Jingyuan Yang, Li Yang, Lvhua Guo, Tao Luo   +7 more
doaj   +2 more sources

Tumor glucose reprogramming suppresses cuproptosis: A review [PDF]

Cuproptosis is a copper-dependent form of regulated cell death that begins when ferredoxin 1 (FDX1) reduces Cu²⁺ to Cu¹⁺, allowing the ion to bind lipoylated enzymes of the tricarboxylic-acid (TCA) cycle, drive protein aggregation, dismantle iron–sulphur
Chen, Jing-Song, Ding, Yi-Hang, Song, Xiao-Hang   +2 more
core   +2 more sources

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi, Azadeh Niknejad, Elaheh Amini   +2 more
wiley   +1 more source

Lactate-binding protein DNMT3A in HRMECs promotes angiogenesis by upregulating VEGFA through HIF-1α lactylation

Genome Biology
Background Ocular neovascularization is a leading cause of blindness. Hypoxia is associated with retinal angiogenesis. Hypoxia results in lactate accumulation, which typically precedes protein lactylation, and this plays a crucial role in ocular ...
Xiaotang Wang, Jiaxing Huang, Wei Fan, Na Li, Hui Yang, Wenxian Yang, Wanqian Li, Ruonan Li, Jiangyi Liu, Xingran Li, Qian Zhou, Shengping Hou   +11 more
doaj   +1 more source

Characterization of protein lactylation in healthy and ischemic mouse hearts

Frontiers in Cardiovascular Medicine
BackgroundRecent findings highlight the growing importance of protein lactylation, a modification driven by lactate, in healthy and diseased states. However, its significance in myocardial infarction (MI) remains unclear.
Daiqian Wu, Yuanjuan Tang, Xingbing Li, Shiqiang Xiong, Zhen Zhang, Jinjuan Fu   +5 more
doaj   +1 more source

On why cancer cells require a great amount of glucose

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract The traditional thinking has been that cancer cells require a great amount of glucose to support their rapid growth, but the reality may be different. We have previously demonstrated that all cancer cells in The Cancer Genome Atlas harbor persistent Fenton reactions in their cytosol, which generate OH− ${\text{OH}}^{-}$ and ultimately kill the
Xuechen Mu, Aoran Liu, Rui Shi, Long Xu, Zhenyu Huang, Ye Zhang, Ying Xu   +6 more
wiley   +1 more source

Histone lactylation enhances GCLC expression and thus promotes chemoresistance of colorectal cancer stem cells through inhibiting ferroptosis

Cell Death and Disease
Colorectal cancer stem cells (CCSCs) play a critical role in mediating chemoresistance. Lactylation is a post-translational modification induced by lactate that regulates gene expression.
Jiao Deng, Yangkun Li, Lanlan Yin, Shuang Liu, Yanqi Li, Wancheng Liao, Lei Mu, Xuelai Luo, Jichao Qin   +8 more
doaj   +1 more source

Lactate-induced histone lactylation by p300 promotes osteoblast differentiation [PDF]

昭和大学博士(歯学)2023年度doctoral ...
南, えりか
core  

RETRACTION: Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells

Advanced Science, EarlyView.
Abstract RETRACTION: J. Li, C. Tang, X. Zhang, R. Xing, and Q. Guo, “Histone Lactylation‐Driven Upregulation of VRK1 Expression Promotes Stemness and Proliferation of Glioma Stem Cells,” Advanced Science 12, no. 44 (2025): e03897, https://doi.org/10.1002/advs.202503897.
wiley   +1 more source