Results 101 to 110 of about 7,170 (205)

Epigenetic and Metabolic Changes That Drive Trained Immunity in Response to Microbes and Vaccines

Immunology, EarlyView.
This graphical abstract illustrates how microbial products, vaccines and microbial metabolites activate pattern‐recognition receptor signalling, inducing metabolic rewiring and epigenetic remodelling. These changes establish long‐lasting trained immunity through the functional reprogramming of haematopoietic progenitors and innate immune cells, thereby
Desalegn Abebaw, Aytenew Atnaf, Bantayehu Addis Tegegne, Abebe Fenta, Bantegzie Selabat, Temesgen Baylie, Yonatan Kindie, Zigale Hibstu Teffera, Mekuriaw Belayneh, Mohammed Jemal, Adane Adugna   +10 more
wiley   +1 more source

A lactylation modification-related prediction model for the diagnosis of ulcerative colitis based on machine learning

Frontiers in Immunology
BackgroundLactylation modification serves as a critical link between metabolic reprogramming and epigenetic regulation, playing a significant role in the progression of both malignant tumors and inflammatory diseases.
Jian Liu, Xiaoyun Kang, Yanxiang Zhou, Jiao Li   +3 more
doaj   +1 more source

Fluvastatin Plus Dipyridamole Suppresses Canine Hemangiosarcoma Growth in Patient‐Derived Xenograft Models Through Lactate Dehydrogenase‐Associated Cholesterol/Lipid Metabolism

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Tumour cells commonly exhibit aerobic glycolysis and produce lactate despite oxygen availability. Lactate dehydrogenase (LDH) catalyses pyruvate‐lactate interconversion and regulates intracellular lactate levels. Endothelial cells also depend on glycolysis for ATP production, which prompted us to investigate LDH in canine hemangiosarcoma (HSA),
Tamami Suzuki, Suzune Tanaka, Keika Kishimoto, Takuma Goto, Jumpei Yamazaki, Takashi Kimura, Keisuke Aoshima   +6 more
wiley   +1 more source

Exercise-induced lactylation

Journal of Human Sport and Exercise
The exercise-induced rise in lactate is traditionally considered a by-product of metabolism, which triggers a metabolism-regulating post-translational modification, lactylation. The dynamic properties of lactylation during physical exercise and how this biological process occurs in mitochondria-lipid droplet interactions are summarized in this review ...
Jiahe Zhang, Zhujun Mao, Junjie Liu
openaire   +1 more source

Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma

Genome Biology
Background Lactylation, a post-translational modification, is increasingly recognized for its role in cancer progression. This study investigates its prevalence and impact in oral squamous cell carcinoma (OSCC). Results Immunohistochemical staining of 81
Fengyang Jing, Lijing Zhu, Jianyun Zhang, Xuan Zhou, Jiaying Bai, Xuefen Li, Heyu Zhang, Tiejun Li   +7 more
doaj   +1 more source

Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells by machine learning

Frontiers in Immunology
BackgroundAn increasing number of studies have revealed a link between lactylation and tumor initiation and progression. However, the specific impact of lactylation on inter-patient heterogeneity and recurrence in glioblastoma (GBM) remains to be further
Yifan Xu, Chonghui Zhang, Jinpeng Wu, Pin Guo, Nan Jiang, Chao Wang, Yugong Feng   +6 more
doaj   +1 more source

Hypoxia and the cytoskeleton

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

The Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min, Órlaith C. Henry, Luke A. J. O'Neill   +2 more
wiley   +1 more source

Lactate and lactylation in macrophage polarization of sepsis

Frontiers in Cellular and Infection Microbiology
Sepsis, which is characterized by potentially fatal multiple organ dysfunction, is caused by an abnormal host response to a major infection. During sepsis, the pathogen stimulates the host to activate resistance mechanisms that enhance immune cells’ oxygen consumption in inflammatory tissues and cells, and promote aerobic glycolysis.
Sun, Jian, Zhang, Min, Zhang, Li, Zhang, Xinyue, Zhang, Jingxiao   +4 more
openaire   +2 more sources

Prognostic and therapeutic response prediction in glioblastoma multiforme using a lactylation-associated gene signature

Discover Oncology
Background Glioblastoma (GBM) is a highly aggressive brain tumor characterized by immunosuppressive tumor microenvironment and metabolic reprogramming. Dysregulated lactate metabolism has been observed in the glioma microenvironment, yet the functional ...
Huan Zhu, Guanjun Li, Tingting Li, Xiangdi Yang, Yongqin Yang, Yifei Li, Zhigang Liu   +6 more
doaj   +1 more source