Results 101 to 110 of about 5,991 (236)

Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley   +1 more source

Opioids in breast cancer: Between analgesia and modulation of tumour progression

British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.
Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun, Anna Tankiewicz‐Kwedlo, Dariusz Pawlak   +2 more
wiley   +1 more source

Lactate and lysine lactylation of histone regulate transcription in cancer

Heliyon
Histone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yunhao Yang, Nanzhi Luo, Zhipeng Gong, Wenjing Zhou, Yin Ku, Yaohui Chen   +5 more
doaj   +1 more source

OSA Initiates Histone Lactylation That Drives PDE4B/FUS/AGT Axis to Pulmonary Hypertension

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study illustrates how chronic intermittent hypoxia (CIH) in obstructive sleep apnea (OSA) leads to hypertension via increased oxidative stress and mitochondrial dysfunction in pulmonary artery smooth muscle cells (PASMCs), causing glycolytic dysregulation. Lactate accumulation enhances histone lactylation, upregulating phosphodiesterase 4B (PDE4B),
Li Yang, Qing Ni, Yan He, Shijie Liu, Lulu Gan, Anni Dai, Yang Hu, Qian Liu, Xueling Yang, Jiqian Li, Yi Tao, Yunyu Li, Mingyue Xu   +12 more
wiley   +1 more source

Lactylation and antitumor immunity

Frontiers in Immunology
Lactylation, a recently discovered post-translational modification (PTM), plays a critical role in cancer biology. Warburg effect induces lactate accumulation, which serves as a metabolic end-product and intercellular signaling mediator within the tumor microenvironment (TME).
Yang, Biao, Li, Lingyu, Shi, Dongmei, Zhong, Tao, Xiong, Huabao   +4 more
openaire   +1 more source

Roles of lactylation in lipid metabolism and related diseases

Cell Death Discovery
Lipids are indispensable molecules that play key roles in cell physiology by acting as structural elements, energy reservoirs, and participants in signal transduction.
Bing Zhao, Zhuoqing Lan, Caixia Li, Hao Wang   +3 more
doaj   +1 more source

The role of lactylation in plasma cells and its impact on rheumatoid arthritis pathogenesis: insights from single-cell RNA sequencing and machine learning [PDF]

IntroductionRheumatoid arthritis (RA) is a chronic autoimmune disorder characterized by persistent synovitis, systemic inflammation, and autoantibody production.
Qining Yang, Tianbao Wang, Tiejun Shi, Weicong Fu, Yehong Lu   +4 more
core   +1 more source

Identification and Screening of Lactate‐Related Genes as Molecular Markers for Early Diagnosis of Steroid‐Induced Osteonecrosis of the Femoral Head

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Identification and validation of lactate‐related genes biomarkers for steroid‐induced osteonecrosis of the femoral head through integrated bioinformatics analysis, machine learning, and experimental verification. ABSTRACT Steroid‐induced osteonecrosis of the femoral head (SONFH) is a major cause of disability among young and middle‐aged adults. However,
Zehua Wang, Shuhang Dong, Kaige Xu, Xinyu Tang, Sijia Guo, Yaping Jiang, Yingze Zhang, Tao Li   +7 more
wiley   +1 more source

Obesity Disrupts H3K4me3‐Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Obesity disrupts macrophage adaptation to hypoxic microenvironments. In lean conditions, hypoxia induces H3K4me3‐dependent transcriptional programs that promote lactate accumulation, histone lactylation, and efficient efferocytosis. Diet‐induced obesity impairs this epigenetic–metabolic response, resulting in reduced lactate accumulation, defective ...
Kentaro Takahashi, Julia Drolet, Jinghua Liu, Jasmine R. Jackson, Madison Babcock, Muthusamy Thiruppathi, Milie Fang, Tyler Paul, Gayathri Ganesh, Yuri Fukasawa, Yoshikiyo Akasaka, Giamila Fantuzzi, Elizaveta V. Benevolenskaya, Timothy J. Koh, Norifumi Urao   +14 more
wiley   +1 more source

MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis

Advanced Science
Lactate plays diverse roles in brain pathophysiology, including ischemic stroke. Here, the role of lysine lactylation, an epigenetic modification of lactate, in cerebral ischemia is investigated.
Min Sun, Yuxin Zhang, Rui Mao, Yan Chen, Pinyi Liu, Lei Ye, Siyi Xu, Junqiu Jia, Shu Shu, Huiya Li, Yanping Yin, Shengnan Xia, Yanting Chen, Yun Xu   +13 more
doaj   +1 more source