Results 101 to 110 of about 5,491 (207)

Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma

Genome Biology
Background Lactylation, a post-translational modification, is increasingly recognized for its role in cancer progression. This study investigates its prevalence and impact in oral squamous cell carcinoma (OSCC). Results Immunohistochemical staining of 81
Fengyang Jing, Lijing Zhu, Jianyun Zhang, Xuan Zhou, Jiaying Bai, Xuefen Li, Heyu Zhang, Tiejun Li   +7 more
doaj   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, Volume 117, Issue 8, Page 2064-2084, August 2026.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Exercise-induced lactylation

Journal of Human Sport and Exercise
The exercise-induced rise in lactate is traditionally considered a by-product of metabolism, which triggers a metabolism-regulating post-translational modification, lactylation. The dynamic properties of lactylation during physical exercise and how this biological process occurs in mitochondria-lipid droplet interactions are summarized in this review ...
Jiahe Zhang, Zhujun Mao, Junjie Liu
openaire   +1 more source

Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma

BMC Cancer
Background Glioblastoma (GBM) is the most aggressive adult brain tumor, marked by intratumoral heterogeneity and therapy resistance. Metabolic reprogramming through histone lactylation has been linked to tumor progression and immune suppression. However,
Rui Han, Guangfan Chi, Dongjie Sun, Ziran Xu, Liangfu Zhou, Kan Xu   +5 more
doaj   +1 more source

Lactate and lysine lactylation of histone regulate transcription in cancer

Heliyon
Histone lysine modifications were well-established epigenetic markers, with many types identified and extensively studied. The discovery of histone lysine lactylation had revealed a new form of epigenetic modification.
Yunhao Yang, Nanzhi Luo, Zhipeng Gong, Wenjing Zhou, Yin Ku, Yaohui Chen   +5 more
doaj   +1 more source

Lactate and lactylation in macrophage polarization of sepsis

Frontiers in Cellular and Infection Microbiology
Sepsis, which is characterized by potentially fatal multiple organ dysfunction, is caused by an abnormal host response to a major infection. During sepsis, the pathogen stimulates the host to activate resistance mechanisms that enhance immune cells’ oxygen consumption in inflammatory tissues and cells, and promote aerobic glycolysis.
Sun, Jian, Zhang, Min, Zhang, Li, Zhang, Xinyue, Zhang, Jingxiao   +4 more
openaire   +2 more sources

Correction to “POU2F1 Promotes Chemoresistance in Colorectal Cancer Cells via Attenuates the MDR2 Degradation Mediated by PPP1R11 Lactylation”

Advanced Science, EarlyView.
wiley   +1 more source

Lactate and lactylation in intervertebral disc degeneration

Frontiers in Molecular Biosciences
The unique hypoxic microenvironment of the intervertebral disc, characterized by its avascularity and restricted nutrient exchange, drives a shift in cellular metabolism towards anaerobic glycolysis. This metabolic adaptation results in the accumulation of significant lactate levels.
Liu, Yadong, Yang, Jihao, Wang, Zihui, Fu, Jing, Liu, Hongpeng, Lu, Zekun, Dong, Jinwei, Li, Zhong, Mao, Qiuyue, Li, Chunlan, Ma, Hui   +10 more
openaire   +2 more sources

Prognostic and therapeutic response prediction in glioblastoma multiforme using a lactylation-associated gene signature

Discover Oncology
Background Glioblastoma (GBM) is a highly aggressive brain tumor characterized by immunosuppressive tumor microenvironment and metabolic reprogramming. Dysregulated lactate metabolism has been observed in the glioma microenvironment, yet the functional ...
Huan Zhu, Guanjun Li, Tingting Li, Xiangdi Yang, Yongqin Yang, Yifei Li, Zhigang Liu   +6 more
doaj   +1 more source

Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications

Drug Design, Development and Therapy
Yuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street ...
Qiu Y, Shao X
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