Results 121 to 130 of about 7,170 (205)

LAMC2+ Epithelial Cells Drive Bladder Cancer Progression and Predict Immunotherapy Response via SERPINB3/STAT3/CD44 Axis

Cancer Science, Volume 117, Issue 11, Page 3071-3085, November 2026.
This study identified LAMC2+ epithelial cells through single‐cell sequencing and found that high expression of LAMC2 is associated with the malignant progression of bladder cancer. HdWGCNA and transcriptome sequencing revealed the SerpinB3/STAT3/CD44 axis. Diosmetin was selected as a potential LAMC2 inhibitor.
Yutong Chen, Yunzhong Jiang, Zezhong Yang, Minxuan Jing, Wentai Wu, Jiale He, Lu Wang, Minghai Ma, Yaodong Zhang, Min Wang, Jianpeng Li, Yuanchun Pu, Bingliang He, Yanjia Liu, Kaibo Mi, Hang Liu, Mengzhao Zhang, Jinhai Fan   +17 more
wiley   +1 more source

Both L-lactyl and D-lactyl enantiomers modify histones in mouse testis

Abstract Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues.
Manessier, Julie, Hijazi, Hassan, Brugière, Sabine, Courçon, Marie, Masselon, Christophe, de la Iglesia, Alberto, Cocquet, Julie, Pflieger, Delphine   +7 more
openaire   +2 more sources

tRNA‐Derived Small RNAs in Digestive Cancers: From Translational Regulation to Immune and Extracellular Communication

Cancer Science, Volume 117, Issue 11, Page 2924-2937, November 2026.
tRNA‐derived small RNAs (tsRNAs) function in digestive cancers across three scales: intracellular translational and metabolic control, extracellular vesicle–mediated immune remodeling, and systemic and host–microbe communication. This review organizes these mechanisms by evidence strength, from well‐established intracellular roles to emerging ...
Wang Xitan, Li Han
wiley   +1 more source

Protein Lysine Lactylation in DNA Damage Response: Regulatory Mechanisms and Emerging Functions. [PDF]

Biomolecules
Pei X, Zhang J, Gao Y, Pan Z, Wang Y, Wang L, Wang Z, Ding GB, Stauber RH, Ni T, Hao S.   +10 more
europepmc   +1 more source

Lactylation and exercise: A molecular link to disease alleviation (Review). [PDF]

Mol Med Rep
Wang J, Wu L.
europepmc   +1 more source

Lysine lactylation in glioma: from metabolic stress to epigenetic remodeling and therapeutic resistance. [PDF]

Front Cell Dev Biol
Hu X, Yang L, Hu Y, Cui H.
europepmc   +1 more source

Lactate-Driven Biphasic Reprogramming of Macrophage Immune Responses. [PDF]

Metabolites
Guo Q, Ren P, He L, Gao J, Lu R, Wang Y, Zhang Z, Han X, Zhang X, Fang C.   +9 more
europepmc   +1 more source

Mapping the intellectual landscape of lactylation research: a bibliometric analysis of global trends and emerging frontiers. [PDF]

Front Pharmacol
Wang J, Li Z, Li X, Liu X, Zhong Z, Wan Y, Liang H.   +6 more
europepmc   +1 more source

Correction: Research progress on protein lactylation in female reproductive disease: molecular mechanisms, functions, and therapeutic implications. [PDF]

Front Pharmacol
Shen X, Chen Y, Deng H, Zhang N, Xu L.
europepmc   +1 more source

Lactylation in gastric cancer: From mechanisms to clinical applications (Review). [PDF]

Mol Med Rep
Fang Y, Chen P, Gao Y, Li Y, Li X.
europepmc   +1 more source