Results 121 to 130 of about 5,991 (236)

Lactylation in digestive system tumors: from mechanisms to therapeutic target

Frontiers in Oncology
Lactylation, a recently identified epigenetic modification derived from lactate metabolism, has emerged as a key regulator linking cellular metabolic states to chromatin remodeling and gene transcription.
Jun Wei, Jun Wei, Jun Wei, Qian Ding, Hongjun Wang, Yang Liu   +5 more
doaj   +1 more source

Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue [PDF]

IntroductionThis study explores the effects of moderate-intensity exercise on protein lactylation in mouse muscle tissue metabolism.MethodsHealthy adult mice running for 6 weeks as an exercise model and sedentary mice as the control were used to perform ...
Fang Wang, Jiahui Chang, Jiahui Chang, Jiahui Chang, Ping Qian, Ting Zhang, Ting Zhang, Ting Zhang, Wanyu Wu, Wanyu Wu, Wanyu Wu, Xuejia He, Zhaoxu Lu   +12 more
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Potential role of lactylation in intrinsic immune pathways in lung cancer

Frontiers in Pharmacology
Lung cancer, one of the most lethal malignancies, has seen its therapeutic strategies become a focal point of significant scientific attention. Intrinsic immune signaling pathways play crucial roles in anti-tumor immunity but face clinical application ...
Mengdie Huang, Ye Jin, Dandan Zhao, Xingren Liu   +3 more
doaj   +1 more source

Innate Immunity Champions: The Diverse Functions of Macrophages [PDF]

Macrophages are instrumental in maintaining tissue homeostasis, modulating inflammation and driving regeneration. The advent of omics techniques has led to the identification of numerous tissue-specific macrophage subtypes, thereby introducing the ...
Biscu, Francesca, Cicia, Donatella, Matteoli, Gianluca, Pridans, Clare, Zouzaf, Anissa   +4 more
core   +3 more sources

Lactylation and tumor immune regulation: insights from recent studies

Frontiers in Immunology
Lactate, a major product of glycolysis, accumulates abundantly in the tumor microenvironment (TME), serving not only as a hallmark of metabolic dysregulation but also as a key driver of immunosuppression.
Chunhong Li, Xiulin Jiang, Yixiao Yuan, Qiang Wang   +3 more
doaj   +1 more source

Characterization of lactylation-based phenotypes and molecular biomarkers in sepsis-associated acute respiratory distress syndrome

Scientific Reports
Sepsis-associated acute respiratory distress syndrome (ARDS) is a heterogeneous disease with high morbidity and mortality. Lactylation plays a crucial role in sepsis and sepsis-induced lung injury.
Yiheng Wang, An Wei, Zixuan Su, Yunyi Shi, Xinqiu Li, Lixian He   +5 more
doaj   +1 more source

Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer [PDF]

Hara T., Meng S., Arao Y., et al. Recent Findings in N6-Methyladenosine Modification and Significance in Pancreatic Cancer. Cancer Medicine 14, e70934 (2025); https://doi.org/10.1002/cam4.70934.Background: RNA modifications are widely detected in cells ...
Arao, Yasuko, Hara, Tomoaki, Inoue, Kana, Ishii, Hideshi, Kitagawa, Toru, Meng, Sikun, Ofusa, Ken, Rennie, Sarah, Saito, Yoshiko   +8 more
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Ubiquitous protein lactylation in health and diseases

Cellular & Molecular Biology Letters
AbstractFor decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important roles in cellular metabolism but also cellular communications, which can transcend compartment barriers and can occur within and among different cells, tissues and ...
Junyong Wang, Ziyi Wang, Qixu Wang, Xiao Li, Yaping Guo   +4 more
openaire   +3 more sources

The role of nonhistone lactylation in disease

Heliyon
In 2019, a novel post-translational modification termed lactylation was identified, which established a connection among lactate, transcriptional regulation and epigenetics.
Hao Yu, Tingting Zhu, Dongwen Ma, Xiaohan Cheng, Shengjia Wang, Yongzhong Yao   +5 more
doaj   +1 more source

H4K79 and H4K91 histone lactylation, newly identified lactylation sites enriched in breast cancer

Journal of Experimental & Clinical Cancer Research
Abstract Metabolic reprogramming and epigenetic modification are two hallmarks of cancer. Protein lysine lactylation (Kla) is a novel type of glycolysis lactate-triggered posttranslational modification. However, the role of Kla in breast cancer (BC) remains largely unknown.
Liu, Jiena, Zhao, Liuying, Yan, Meisi, Jin, Shengye, Shang, Lingmin, Wang, Jianyu, Wang, Qin, Zhao, Shilu, Shen, Zibo, Liu, Tong, Wu, Hao, Pang, Da   +11 more
openaire   +2 more sources