Results 111 to 120 of about 5,991 (236)

Integrated analysis of single-cell RNA-seq and spatial transcriptomics to identify the lactylation-related protein TUBB2A as a potential biomarker for glioblastoma in cancer cells by machine learning

Frontiers in Immunology
BackgroundAn increasing number of studies have revealed a link between lactylation and tumor initiation and progression. However, the specific impact of lactylation on inter-patient heterogeneity and recurrence in glioblastoma (GBM) remains to be further
Yifan Xu, Chonghui Zhang, Jinpeng Wu, Pin Guo, Nan Jiang, Chao Wang, Yugong Feng   +6 more
doaj   +1 more source

Lactylation in diabetes mellitus and its complications: mechanisms of action and therapeutic potential - recent advances [PDF]

BackgroundDiabetes mellitus (DM) and its complications represent a global health burden. Lactylation, a novel post-translational modification (PTM) linking metabolism to epigenetic regulation, has emerged as a key mediator in metabolic disorders ...
Lan Liu, Min Zhou, Xiaoshu Wang, Yihong Sun   +3 more
core   +1 more source

Multi-omics reveals lactylation-driven regulatory mechanisms promoting tumor progression in oral squamous cell carcinoma

Genome Biology
Background Lactylation, a post-translational modification, is increasingly recognized for its role in cancer progression. This study investigates its prevalence and impact in oral squamous cell carcinoma (OSCC). Results Immunohistochemical staining of 81
Fengyang Jing, Lijing Zhu, Jianyun Zhang, Xuan Zhou, Jiaying Bai, Xuefen Li, Heyu Zhang, Tiejun Li   +7 more
doaj   +1 more source

Histone Changes as a Response to Lactic Acid Selection in Cells of Austrofundulus limnaeus [PDF]

The killifish Austrofundulus limnaeus is an extremophile native to small temporary ponds of Venezuela. Normal embryonic development of A. limnaeus is segmented into up to three stages of metabolic depression (diapause), and both developing and diapausing
Hughes, Chelsea, Podrabsky, Jason, Tran, Lori   +2 more
core   +1 more source

Non-histone lactylation: unveiling its functional significance [PDF]

Lactylation, a newly discovered protein posttranslational modification (PTM) in 2019, primarily occurs on lysine residues. Lactylation of histones was initially identified, and subsequent studies have increasingly demonstrated its widespread presence on ...
Pusong Shi, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Shaolu Zhang, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma, Yongjie Ma   +10 more
core   +1 more source

Histone lactylation [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Exploring lactylation and cancer biology: insights from pathogenesis to clinical applications [PDF]

As a byproduct of glycolysis, lactate functions as a signaling molecule, a substrate for energy metabolism, and a regulator of the tumor microenvironment (TME).
Jiannan Li, Qianchuang Sun, Zixuan Gou
core   +1 more source

Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma

BMC Cancer
Background Glioblastoma (GBM) is the most aggressive adult brain tumor, marked by intratumoral heterogeneity and therapy resistance. Metabolic reprogramming through histone lactylation has been linked to tumor progression and immune suppression. However,
Rui Han, Guangfan Chi, Dongjie Sun, Ziran Xu, Liangfu Zhou, Kan Xu   +5 more
doaj   +1 more source

Targeting Lactylation: From Metabolic Reprogramming to Precision Therapeutics in Liver Diseases

Biomolecules
Lactylation, a recently identified post-translational modification (PTM) triggered by excessive lactate accumulation, has emerged as a crucial regulator linking metabolic reprogramming to pathological processes in liver diseases.
Qinghai Tan, Mei Liu, Xiang Tao
doaj   +1 more source

Lactate-induced lactylation: from basic research to clinical perspectives [PDF]

Lactate was initially considered a metabolic waste product of glycolysis under hypoxic conditions until the emergence of the lactate shuttle hypothesis.
Bin Liu, Henghe Shi, Junduo Wu, Sijie Jin, Yifei Zou   +4 more
core   +1 more source