Results 111 to 120 of about 5,491 (207)

Both L-lactyl and D-lactyl enantiomers modify histones in mouse testis

Abstract Dynamic histone post-translational modifications are crucial to precisely orchestrate gene expression programs. The recently discovered histone lysine lactylation has already been explored in various pathological contexts, but less in normal tissues.
Manessier, Julie, Hijazi, Hassan, Brugière, Sabine, Courçon, Marie, Masselon, Christophe, de la Iglesia, Alberto, Cocquet, Julie, Pflieger, Delphine   +7 more
openaire   +2 more sources

HMGA1 Lactylation-Mediated Regulation of the SP1/VEGFA Axis in Pathological Angiogenesis Under Diabetic Retinopathy. [PDF]

Diabetes
Hou J, Liu S, Zhou Y, Fan J, Xiao D, Wang C, Lin S, Tao L, Jiang Z.   +8 more
europepmc   +1 more source

A Novel Approach to Neuropathic Pain Treatment: Lactylation Targeting Microglia. [PDF]

Mol Neurobiol
Chen M, Yang F, Sun Y, Feng S.
europepmc   +1 more source

Lactate and Lactylation in Pulmonary Hypertension: Comprehensive Landscape and Future Perspectives. [PDF]

Int J Med Sci
Dai Q, Cai Y, Wang X, Li X, Zheng R, Cao X, Zhang C, Xu J, Yi J, Song L, Dai A.   +10 more
europepmc   +1 more source

Non-histone lactylation in cancer: current advances and clinical implications. [PDF]

Front Immunol
Yang RL, Liang Y.
europepmc   +1 more source

Lactate metabolism and lactylation in female reproductive diseases: From metabolic rewiring to biomarkers and translational therapeutics. [PDF]

Clin Transl Med
Qiao J, Xiao Y, Cheng Y, Xu W, Shu J, Li S.   +5 more
europepmc   +1 more source

Lactate Metabolism and Protein Lactylation in Diabetic Kidney Disease: A Narrative Review. [PDF]

Diabetes Metab Syndr Obes
Sun L, Yang Y, Pan W, Zhang C, Lu J, Guo S, Zhu Y, Zhu M.   +7 more
europepmc   +1 more source

Causal Effects and Single-Cell Microenvironmental Implications of Germline Variant-Regulated Lactylation-Related Pro-Oncogenic Genes in Colorectal Cancer. [PDF]

Hum Mutat
Sheng B, Wang J.
europepmc   +1 more source

Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review). [PDF]

Oncol Rep
Xu Y, Wang W, Zhang Y, Fan Y, Dong W, Yang J.   +5 more
europepmc   +1 more source

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review). [PDF]

Int J Mol Med
Chen L, Gao F, Mei Q, Li Y, Cai Q, Feng X.   +5 more
europepmc   +1 more source