Results 111 to 120 of about 7,170 (205)

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Single-cell and spatial transcriptomics reveal lactylation-associated tumor cell clusters and define a prognostic risk model in glioblastoma

BMC Cancer
Background Glioblastoma (GBM) is the most aggressive adult brain tumor, marked by intratumoral heterogeneity and therapy resistance. Metabolic reprogramming through histone lactylation has been linked to tumor progression and immune suppression. However,
Rui Han, Guangfan Chi, Dongjie Sun, Ziran Xu, Liangfu Zhou, Kan Xu   +5 more
doaj   +1 more source

BDH1 Attenuates Macrophage Foam Cell Formation and Inflammation in Atherosclerosis Via Modulating Histone H3K9 Acylation Balance and Activating PPAR Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
In atherosclerotic lesions, BDH1 expression is downregulated in plaque macrophages. In ox‐LDL‐induced RAW264.7 macrophages, BDH1 overexpression maintains H3K9 acylation homeostasis by upregulating H3K9ac and downregulating H3K9bhb, thereby increasing cell viability, reducing lipid accumulation, decreasing TNF‐α, and increasing IL‐10.
Yu Wang, Yi Wang, Qinghong Liu, Mao Tian, Bin Wang, Qiang Lin, Shuiying Huang   +6 more
wiley   +1 more source

Lactate and lactylation in intervertebral disc degeneration

Frontiers in Molecular Biosciences
The unique hypoxic microenvironment of the intervertebral disc, characterized by its avascularity and restricted nutrient exchange, drives a shift in cellular metabolism towards anaerobic glycolysis. This metabolic adaptation results in the accumulation of significant lactate levels.
Liu, Yadong, Yang, Jihao, Wang, Zihui, Fu, Jing, Liu, Hongpeng, Lu, Zekun, Dong, Jinwei, Li, Zhong, Mao, Qiuyue, Li, Chunlan, Ma, Hui   +10 more
openaire   +2 more sources

SIRT7 Mediated‐PTEN Desuccinylation Drives Gastric Tumorigenesis by Activating PI3K/AKT Pathway

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
SIRT7 is upregulated in gastric cancer (GC). SIRT7‐mediated desuccinylation of PTEN at K322/K330 promotes its degradation, thereby activating the PI3K/AKT signaling pathway and ultimately driving GC progression. ABSTRACT SIRT7 is linked to cancer, yet its function in gastric cancer (GC) remains unclear.
Bingling Liao, Sheng Hu, Qilin Zhang, Qihua Xu, Tianning Tian   +4 more
wiley   +1 more source

The Efferocytosis‐Driven Macrophage Polarization: A Concerto in the Tumor Immunosuppressive Microenvironment

MedComm, Volume 7, Issue 11, November 2026.
Efferocytosis is a key process for macrophages to clear apoptotic cells, which undergoes the “ Find Me” chemotaxis signal stage, the “eat me” phagocytosis recognition stage and the “digest me” digestion stage in turn. During the aforementioned three stages, various signaling molecules released by apoptotic cells can promote the phenotypic polarization ...
Qiuping Chen, Chunzhi Wu, Changquan Huang, Hang Zhou   +3 more
wiley   +1 more source

PRAME Augments K63‐Linked Ubiquitination and Stabilization of METTL3 to Promote Lung Adenocarcinoma Metastasis

MedComm, Volume 7, Issue 11, November 2026.
PRAME promotes lung adenocarcinoma metastasis by inducing K63‐linked ubiquitination of METTL3 at lysine 235, thereby enhancing METTL3 stability and m6A methyltransferase complex assembly. Elevated METTL3 activity increases m6A modification of TGFB2 mRNA, leading to activation of TGF‐β signaling and metastatic progression of lung adenocarcinoma (LUAD ...
Xia Yang, Xuemei Xu, Yaxuan Zhang, Jiamei Guo, Zhiyu Ye, Qiaorui Bai, Xiuqiao Yang, Shujun Liang, Xiang Dong, Xin Zhang, Jiyong Gu, Shuqin Dai, Hongchun Du, Meiwan Chen, Tianyu Tao, Hongyu Guan, Jueheng Wu, Han Tian, Junchao Cai, Mengfeng Li, Xu Li, Yi Yang   +21 more
wiley   +1 more source

Atherosclerosis: From Pathogenesis to Therapeutic Interventions

MedComm, Volume 7, Issue 11, November 2026.
The diagram outlines the core mechanisms driving atherosclerosis, including endothelial dysfunction, inflammatory responses, phenotypic switching of smooth muscle cells, and the gut–vascular axis. It also presents the corresponding therapeutic approaches now under development, such as gene therapies, immunotherapies, and nanotechnology platforms ...
Enge Zhou, Chenxi Zhan, Yuting Li, Yi Zeng, Renfei Luo, Xin Ouyang, Shixing Liu, Renqiang Yang, Nianlong Yan, Long Jiang   +9 more
wiley   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

Histone Lactylation in Diseases: Regulation by Traditional Chinese Medicine and Therapeutic Implications

Drug Design, Development and Therapy
Yuyue Qiu, Xiaoni Shao College of Pharmacy and Food, Southwest Minzu University, Chengdu, Sichuan, 610225, People’s Republic of ChinaCorrespondence: Xiaoni Shao, College of Pharmacy and Food, Southwest Minzu University, #168 Dajian Street ...
Qiu Y, Shao X
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