Results 81 to 90 of about 5,491 (207)
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
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Targeting Lactylation: From Metabolic Reprogramming to Precision Therapeutics in Liver Diseases
BiomoleculesLactylation, a recently identified post-translational modification (PTM) triggered by excessive lactate accumulation, has emerged as a crucial regulator linking metabolic reprogramming to pathological processes in liver diseases.
Qinghai Tan, Mei Liu, Xiang Tao
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MedComm – Oncology, Volume 5, Issue 3, September 2026.Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K +5 more
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Lactylation in pulmonary fibrosis: current understanding and challenges
Journal of Translational MedicineBackground Pulmonary fibrosis (PF) is a progressive, chronic lung disease, which is accompanied by epithelial cell damage, fibroblast activation, and macrophage polarization; the fibrotic niche is primarily composed of these three cell types.
Bo Li +5 more
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Advanced Science, Volume 13, Issue 43, 3 August 2026.In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu +16 more
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Translational Lung Cancer ResearchLactylation, a recently identified post-translational modification, plays a critical role in tumor progression and immune regulation. However, its cellular heterogeneity and functional impact in lung adenocarcinoma (LUAD) remain poorly understood. This study was designed as exploratory biological research to characterize lactylation-associated patterns
Yang, Ziheng +4 more
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Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.This review elucidates how lactylation, a novel histone modification driven by lactate, regulates colorectal cancer pathogenesis. We summarize its roles in tumor progression, metastasis, stemness, immunosuppression, and therapy resistance, and discusses the promising therapeutic strategies of targeting the lactylation pathway.
Shuilan Yao +4 more
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MedComm, Volume 7, Issue 8, August 2026.NAT1 downregulates PD‐L1 protein expression by acetylating ENO1, which inhibits lactate‐fueled TRAF6/PD‐L1 signaling (left). Conversely, NAT1 deficiency in CRC cells enhances ENO1 activation, leading to increased glycolysis and lactate production. The lactate then binds to TRAF6, promoting its oligomerization and activation.
Yi‐Xuan Liu +18 more
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[Role and Mechanism of Lactylation in Cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancerPost translational modifications (PTMs) can change the properties of a protein by covalent addition of functional groups to one or more amino acids, and influence almost all aspects of normal cell biology and pathogenesis. Lactylation is a novel identified PTM, and has been found in both histone and non-histone proteins.
Qicheng ZHANG, Limin CAO, Ke XU
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