Results 81 to 90 of about 5,991 (236)

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Lactate-driven lactylation of HNRNPA1 orchestrates PKM2 splicing and glycolytic reprogramming in bladder cancer

Journal of Experimental & Clinical Cancer Research
Background Lactylation, a recently identified post-translational modification derived from lactate, has emerged as a regulator of tumor metabolism. However, its functional relevance and molecular targets in bladder cancer (BLCA) remain unclear.
Tianqi Wang, Xiaohong Ma, Yini Wang, Hongquan Liu, Guixin Ding, Yanfei Li, Hejia Yuan, Jie Gao, Fengze Sun, Yicheng Guo, Jian Ma, Jitao Wu   +11 more
doaj   +1 more source

Air pollution and alveolar health [PDF]

Exposure to air pollution has been associated with up to 9 million premature deaths per year worldwide, with the respiratory system a key site for its effects.
Richeldi, Luca, Sofia, Carmelo
core   +1 more source

CD90 Promotes Gastric Cancer Progression by Regulating SLC1A5‐Mediated Glutamine Metabolism Through YY1

Cancer Science, EarlyView.
The CD90‐YY1‐SLC1A5 axis plays a significant role in gastric cancer. CD90 promotes the binding of YY1 to the SLC1A5 promoter. CD90 regulates SLC1A5‐mediated glutamine metabolism and ferroptosis. ABSTRACT CD90 (THY1) is a cell surface glycoprotein that plays a crucial role in the occurrence and development of various malignant tumors.
Zihua Zhou, Siyi Liu, Chenyu Zhang, Jun Deng, Lin Liang, Yanhong Zhou   +5 more
wiley   +1 more source

An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions [PDF]

Epigenetic changes are changes in gene expression that do not involve alterations to the DNA sequence. These changes lead to establishing a so-called epigenetic code that dictates which and when genes are activated, thus orchestrating gene regulation and
Castagna, Claudia, Lossi, Laura, Merighi, Adalberto   +2 more
core   +1 more source

Mechanistic Insights Into Recurrent Implantation Failure: The Lactate–H3K18la–SLC7A11 Axis Explored via Endometrial Organoid and Blastoid–Endometrial Cell Implantation Models

Cell Proliferation, EarlyView.
Clinical samples first revealed impaired lactate synthesis in RIF patients. Subsequently, using endometrial organoids and a blastoid‐endometrial cell implantation model, we demonstrated that lactate enhances endometrial receptivity via H3K18la‐mediated SLC7A11 activation.
Lingling Dong, Xiaobin Sun, Shiyu An, Jinfeng Xiang, Lingmin Hu, Dan Yao, Jiaqian Chang, Ruizhe Jia, Yang Yang, Shuxian Wang   +9 more
wiley   +1 more source

Lactate and lactylation in cancer

Signal Transduction and Targeted Therapy
Abstract Accumulated evidence has implicated the diverse and substantial influence of lactate on cellular differentiation and fate regulation in physiological and pathological settings, particularly in intricate conditions such as cancer. Specifically, lactate has been demonstrated to be pivotal in molding the tumor microenvironment (TME ...
Jie Chen, Ziyue Huang, Ya Chen, Hao Tian, Peiwei Chai, Yongning Shen, Yiran Yao, Shiqiong Xu, Shengfang Ge, Renbing Jia   +9 more
openaire   +3 more sources

Transcending frontiers in prostate cancer: the role of oncometabolites on epigenetic regulation, CSCs, and tumor microenvironment to identify new therapeutic strategies [PDF]

Prostate cancer, as one of the most prevalent malignancies in males, exhibits an approximate 5-year survival rate of 95% in advanced stages. A myriad of molecular events and mutations, including the accumulation of oncometabolites, underpin the genesis ...
Alcon-Rodriguez, Sergio, Ambrosini, Giulia, Cordani, Marco, Dando, Ilaria, Gonzalez-Menendez, Pedro, Sainz, Rosa M, Velasco, Guillermo, Zarrabi, Ali   +7 more
core   +1 more source

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation

Cell Proliferation, EarlyView.
During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu, Danning Ma, Jia Song, Boon Chin Heng, Ying Huang, Xuehui Zhang, Mingming Xu, Yan Wei, Tai Wei, Jinqi Wei, Xuliang Deng   +10 more
wiley   +1 more source

The role of protein lactylation in brain health and disease: current advances and future directions

Cell Death Discovery
Lactate, the end product of glycolysis, plays a crucial role in cellular signaling and metabolism. The discovery of lactylation, a novel post-translational modification, has uncovered the role of lactate in regulating diseases, especially in the brain ...
Mingrui Han, Wenfeng He, Wengen Zhu, Linjuan Guo   +3 more
doaj   +1 more source