Results 21 to 30 of about 6,166,097 (293)
Frontiers in Molecular Biosciences, 2022 Glutathione peroxidase 4 (GPX4) is one of the most important antioxidant enzymes. As the key regulator of ferroptosis, GPX4 has attracted considerable attention in the fields of cancer, cardiovascular, and neuroscience research in the past 10 years.
Can Cui, Fei Yang, Qian Li
semanticscholar +1 more source
Nucleic Acids Research, 2021 Faithful genome integrity maintenance plays an essential role in cell survival. Here, we identify the RNA demethylase ALKBH5 as a key regulator that protects cells from DNA damage and apoptosis during reactive oxygen species (ROS)-induced stress. We find
Fang Yu +8 more
semanticscholar +1 more source
Signal Transduction and Targeted Therapy, 2021 More and more in-depth studies have revealed that the occurrence and development of tumors depend on gene mutation and tumor heterogeneity. The most important manifestation of tumor heterogeneity is the dynamic change of tumor microenvironment (TME ...
Wen Li +4 more
semanticscholar +1 more source
Decoding Post-Translational Modification Crosstalk With Proteomics
Molecular & Cellular Proteomics, 2021 Post-translational modification (PTM) of proteins allows cells to regulate protein functions, transduce signals and respond to perturbations. PTMs expand protein functionality and diversity, which leads to increased proteome complexity.
Mario Leutert, S. Entwisle, J. Villén
semanticscholar +1 more source
Post‐translational modification and phenotype
Proteomics, 2023 Post-translational modification (PTM) greatly expands the molecular diversity of a protein. The dynamic decoration of PTMs during the protein lifespan, normally in an amino acid site-specific manner, can induce protein structural and functional ...
Barbora Šalovská, Yansheng Liu
semanticscholar +1 more source
Prediction of histone post-translational modification patterns based on nascent transcription data
Nature Genetics, 2022 The role of histone modifications in transcription remains incompletely understood. Here, we examine the relationship between histone modifications and transcription using experimental perturbations combined with sensitive machine-learning tools ...
Zhong Wang +13 more
semanticscholar +1 more source
Post-Translational Modifications of ATG4B in the Regulation of Autophagy
Cells, 2022 Autophagy plays a key role in eliminating and recycling cellular components in response to stress, including starvation. Dysregulation of autophagy is observed in various diseases, including neurodegenerative diseases, cancer, and diabetes.
Na Yeon Park, Doo Sin Jo, Dong-Hyung Cho
doaj +1 more source
Core Components of Abscisic Acid Signaling and Their Post-translational Modification
Frontiers in Plant Science, 2022 Abscisic acid (ABA) is a major phytohormone that regulates plant growth, development, and abiotic/biotic stress responses. Under stress, ABA is synthesized in various plant organs, and it plays roles in diverse adaptive processes, including seed dormancy,
Junsub Lim, C. Lim, Sung Chul Lee
semanticscholar +1 more source
Expanding the ubiquitin code through post‐translational modification
EMBO Reports, 2015 Lina Herhaus, Ivan Dikić
exaly +2 more sources
Near atmospheric carbon dioxide activates plant ubiquitin cross-linking
BBA Advances, 2023 Background Identifying CO2-binding proteins is vital for our knowledge of CO2-regulated molecular processes. The carbamate post-translational modification is a reversible CO2-mediated adduct that can form on neutral N-terminal α-amino or lysine ε-amino ...
Harry G Gannon, Martin J Cann
doaj +1 more source