Results 1 to 10 of about 28,993 (111)

Editorial: Targeting Protein Post-Translational Modifications (PTMs) for Diagnosis and Treatment of Sepsis [PDF]

Frontiers in Immunology, 2022
Panpan Chang, Panpan Chang, Panpan Chang, Yongqing Li   +3 more
doaj   +4 more sources

Post-Translational Modifications (PTMs) of mutp53 and Epigenetic Changes Induced by mutp53 [PDF]

Biology
Wild-type (wt) p53 and mutant forms (mutp53) play a key but opposite role in carcinogenesis. wtP53 acts as an oncosuppressor, preventing oncogenic transformation, while mutp53, which loses this property, may instead favor this process. This suggests that
Rossella Benedetti, Michele Di Crosta, Gabriella D’Orazi, Mara Cirone   +3 more
doaj   +2 more sources

Post-translational modifications of PLK1: a dynamic regulatory network in cell cycle regulation and tumor progression [PDF]

Frontiers in Cell and Developmental Biology
PLK1 is a highly conserved serine/threonine kinase that plays a central role in mitosis and cell-cycle progression. PLK1 is dynamically regulated by multiple post-translational modifications (PTMs), which coordinate its kinase activity, protein stability,
Wenjing Li, Wenjing Li, Huiping Lin, Donghua Wen   +3 more
doaj   +2 more sources

Evolution and functional cross‐talk of protein post‐translational modifications

Molecular Systems Biology, 2013
Protein post‐translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states.
Pedro Beltrao, Peer Bork, Nevan J. Krogan, Vera van Noort   +3 more
doaj   +2 more sources

Common Post-translational Modifications (PTMs) of Proteins: Analysis by Up-to-Date Analytical Techniques with an Emphasis on Barley. [PDF]

J Agric Food Chem, 2023
Bobalova J, Strouhalova D, Bobal P.
europepmc   +2 more sources

Control of protein stability by post-translational modifications

Nature Communications, 2023
Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee, Henrik M. Hammarén, Mikhail M. Savitski, Sung Hee Baek   +3 more
doaj   +2 more sources

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats. [PDF]

J Proteome Res, 2017
Ratovitski T, O'Meally RN, Jiang M, Chaerkady R, Chighladze E, Stewart JC, Wang X, Arbez N, Roby E, Alexandris A, Duan W, Vijayvargia R, Seong IS, Lavery DJ, Cole RN, Ross CA.   +15 more
europepmc   +2 more sources

Post-translational modifications and their implications in cancer

Frontiers in Oncology, 2023
Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Hashnu Dutta, Hashnu Dutta, Nishant Jain, Nishant Jain   +3 more
doaj   +1 more source

Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress

Redox Biology, 2021
Thiol-based post-translational modifications (PTMs) play a key role in redox-dependent regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated through multiple types of PTMs.
Xiaolu Li, Nicholas J. Day, Song Feng, Matthew J. Gaffrey, Tai-Du Lin, Vanessa L. Paurus, Matthew E. Monroe, Ronald J. Moore, Bin Yang, Ming Xian, Wei-Jun Qian   +10 more
doaj   +1 more source

Special Issue “Structure, Activity, and Function of Protein Methyltransferases”

Life, 2022
Post-translational modifications (PTMs) largely expand the functional diversity of the proteome [...]
Arunkumar Dhayalan, Albert Jeltsch
doaj   +1 more source