Results 1 to 10 of about 27,304 (111)

Editorial: Targeting Protein Post-Translational Modifications (PTMs) for Diagnosis and Treatment of Sepsis [PDF]

Frontiers in Immunology, 2022
Panpan Chang, Panpan Chang, Panpan Chang, Yongqing Li   +3 more
doaj   +4 more sources

Post-Translational Modifications (PTMs) of mutp53 and Epigenetic Changes Induced by mutp53 [PDF]

Biology
Wild-type (wt) p53 and mutant forms (mutp53) play a key but opposite role in carcinogenesis. wtP53 acts as an oncosuppressor, preventing oncogenic transformation, while mutp53, which loses this property, may instead favor this process. This suggests that
Rossella Benedetti, Michele Di Crosta, Gabriella D’Orazi, Mara Cirone   +3 more
doaj   +2 more sources

Control of protein stability by post-translational modifications

Nature Communications, 2023
Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee, Henrik M. Hammarén, Mikhail M. Savitski, Sung Hee Baek   +3 more
doaj   +2 more sources

The Role of Protein Post-Translational Modifications in the Pathogenesis of Nephrolithiasis: Mechanistic Insights and Translational Potential [PDF]

Cells
Nephrolithiasis is a prevalent urological disorder worldwide, whose pathogenesis involves a complex network of crystal formation, cellular injury, and microenvironmental dysregulation.
Wenlong Wan, Baokang Wang, Junyi Yang, Yang Xun, Xiao Yu   +4 more
doaj   +2 more sources

Common Post-translational Modifications (PTMs) of Proteins: Analysis by Up-to-Date Analytical Techniques with an Emphasis on Barley [PDF]

Journal of Agricultural and Food Chemistry, 2023
Pavel Bobal, Janette Bobalová
exaly   +2 more sources

Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats [PDF]

Journal of Proteome Research, 2017
Wenzhen Duan, Robert Cole, Athanasios S Alexandris   +2 more
exaly   +2 more sources

Novel post-translational modifications in cancer

Oncologie
The increasing incidence of cancer highlights the urgency for a deeper understanding of its complex pathogenesis. Recent research has identified novel post-translational modifications (PTMs) as key contributors to cancer. This review examines the role of
Li Dongling, Cai Qinrui, Li Li, Chen Yao, Lin Ling, Zhou Xiaoya, Lin Jianshan, Yang Fan   +7 more
doaj   +2 more sources

Post-translational modifications and their implications in cancer

Frontiers in Oncology, 2023
Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Hashnu Dutta, Hashnu Dutta, Nishant Jain, Nishant Jain   +3 more
doaj   +1 more source

Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress

Redox Biology, 2021
Thiol-based post-translational modifications (PTMs) play a key role in redox-dependent regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated through multiple types of PTMs.
Xiaolu Li, Nicholas J. Day, Song Feng, Matthew J. Gaffrey, Tai-Du Lin, Vanessa L. Paurus, Matthew E. Monroe, Ronald J. Moore, Bin Yang, Ming Xian, Wei-Jun Qian   +10 more
doaj   +1 more source

Special Issue “Structure, Activity, and Function of Protein Methyltransferases”

Life, 2022
Post-translational modifications (PTMs) largely expand the functional diversity of the proteome [...]
Arunkumar Dhayalan, Albert Jeltsch
doaj   +1 more source