Post-Translational Modifications (PTMs) of mutp53 and Epigenetic Changes Induced by mutp53 [PDF]
BiologyWild-type (wt) p53 and mutant forms (mutp53) play a key but opposite role in carcinogenesis. wtP53 acts as an oncosuppressor, preventing oncogenic transformation, while mutp53, which loses this property, may instead favor this process. This suggests that
Rossella Benedetti +3 more
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Antioxidant systems are regulated by nitric oxide-mediated post-translational modifications (NO-PTMs) [PDF]
Frontiers in Plant Science, 2016 Nitric oxide (NO) is a biological messenger that orchestrates a plethora of plant functions, mainly through post-translational modifications (PTMs) such as S-nitrosylation or tyrosine nitration.
Juan Carlos Begara-Morales +7 more
doaj +6 more sources
Editorial: Targeting Protein Post-Translational Modifications (PTMs) for Diagnosis and Treatment of Sepsis [PDF]
Frontiers in Immunology, 2022 Panpan Chang +3 more
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Role of Host-Mediated Post-Translational Modifications (PTMs) in RNA Virus Pathogenesis. [PDF]
Int J Mol Sci, 2020 Being opportunistic intracellular pathogens, viruses are dependent on the host for their replication. They hijack host cellular machinery for their replication and survival by targeting crucial cellular physiological pathways, including transcription, translation, immune pathways, and apoptosis.
Kumar R +4 more
europepmc +4 more sources
Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation. [PDF]
Mol Cell Proteomics, 2016 Histones are abundant chromatin constituents carrying numerous post-translational modifications (PTMs). Such PTMs mediate a variety of biological functions, including recruitment of enzymatic readers, writers and erasers that modulate DNA replication, transcription and repair. Individual histone molecules contain multiple coexisting PTMs, some of which
Schwämmle V +6 more
europepmc +6 more sources
Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score. [PDF]
Oncotarget, 2017 Prostate Cancer (PCa) is a complex and heterogeneous disease. The androgen receptor (AR) and the signal transducer and activator of transcription 3 (STAT3) could be effective targets for PCa therapy. STAT3, a cytoplasmatic latent transcription factor, is a hub protein for several oncogenic signalling pathways and up-regulates the expression of numerous
Cocchiola R +10 more
europepmc +4 more sources
Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats. [PDF]
J Proteome Res, 2017 Post-translational modifications (PTMs) of proteins regulate various cellular processes. PTMs of polyglutamine-expanded huntingtin (Htt) protein, which causes Huntington's disease (HD), are likely modulators of HD pathogenesis. Previous studies have identified and characterized several PTMs on exogenously expressed Htt fragments, but none of them were ...
Ratovitski T +15 more
europepmc +4 more sources
Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration. [PDF]
BiomoleculesNeurodegenerative disorders, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease, are identified and characterized by the progressive loss of neurons and neuronal dysfunction, resulting in cognitive and motor impairment.
Zafar S, Fatima SI, Schmitz M, Zerr I.
europepmc +6 more sources
The Role of Protein Post-Translational Modifications in the Pathogenesis of Nephrolithiasis: Mechanistic Insights and Translational Potential [PDF]
CellsNephrolithiasis is a prevalent urological disorder worldwide, whose pathogenesis involves a complex network of crystal formation, cellular injury, and microenvironmental dysregulation.
Wenlong Wan +4 more
doaj +2 more sources
Adaptable Alchemy: Exploring the Flexibility of Specialized Metabolites to Environmental Perturbations Through Post-Translational Modifications (PTMs). [PDF]
Plants (Basel)Plants are subjected to various stresses during the growth process, including biotic stresses, as well as abiotic stresses such as temperature, drought, salt, and heavy metals. To cope with these biotic and abiotic adversities, plants have evolved complex regulatory mechanisms during their long-term environmental adaptations.
Cimmino L +5 more
europepmc +5 more sources