Post-Translational Modifications in Atopic Dermatitis: Current Research and Clinical Relevance
Frontiers in Cell and Developmental Biology, 2022 Atopic dermatitis (AD) is a chronic and relapsing cutaneous disorder characterized by compromised immune system, excessive inflammation, and skin barrier disruption.
Xin Ma +17 more
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Identification of N-terminal protein acetylation and arginine methylation of the voltage-gated sodium channel in end-stage heart failure human heart [PDF]
, 2014 The α subunit of the cardiac voltage-gated sodium channel, Naᵥ1.5, provides the rapid sodium inward current that initiates cardiomyocyte action potentials.
Batlle, Montserrat +13 more
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PTM-Shepherd: analysis and summarization of post-translational and chemical modifications from open search results [PDF]
Molecular & Cellular Proteomics, 2020 ABSTRACT Open searching has proven to be an effective strategy for identifying both known and unknown modifications in shotgun proteomics experiments. Rather than being limited to a small set of user-specified modifications, open searches identify peptides with any mass shift that may correspond to a single modification or a combination
Daniel J. Geiszler +5 more
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Investigation of post-translational modifications in type 2 diabetes
Clinical Proteomics, 2018 The investigation of post-translational modifications (PTMs) plays an important role for the study of type 2 diabetes. The importance of PTMs has been realized with the advancement of analytical techniques.
Bhaswati Chatterjee, Suman S. Thakur
doaj +1 more source
Development and optimization of a miniaturized western blot-based screening platform to identify regulators of post-translational modifications [PDF]
, 2019 Post-translational modifications (PTMs) are fundamental traits of protein functionality and their study has been addressed using several approaches over the past years.
Gottifredi, Vanesa +2 more
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Vienna-PTM web server: a toolkit for MD simulations of protein post-translational modifications [PDF]
Nucleic Acids Research, 2013 Post-translational modifications (PTMs) play a key role in numerous cellular processes by directly affecting structure, dynamics and interaction networks of target proteins. Despite their importance, our understanding of protein PTMs at the atomistic level is still largely incomplete.
Christian Margreitter +2 more
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An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
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Post-Translational Modification (PTM) Proteomics: Challenges and Perspectives [PDF]
Modern Chemistry & Applications, 2013 Copyright: © 2013 Darie CC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
openaire +1 more source
Advances on Post-translational Modifications Involved in Seed Germination
Frontiers in Plant Science, 2021 Seed germination and subsequent seedling establishment are important developmental processes that undergo extremely complex changes of physiological status and are precisely regulated at transcriptional and translational levels.
Feng Yu +3 more
doaj +1 more source
Epigenomes in Cardiovascular Disease. [PDF]
, 2018 If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA +4 more
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