Results 51 to 60 of about 5,850,387 (280)
Protein Modifications as Potential Biomarkers in Breast Cancer
Biomarker Insights, 2009 A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry
Hongjun Jin, Richard C. Zangar
doaj +2 more sources
Frontiers in Microbiology, 2020 Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system.
Jiao Hu +8 more
doaj +1 more source
The roles of tubulin post-translational modifications in cancer [PDF]
, 2023 "Microtubules are dynamic structures of the cytoskeleton composed by several α/β-tubulin isotypes that may undergo various post-translational modifications (PTMs). This “tubulin code” generates microtubule diversity that modulates
Lopes, Danilo
core
Post-translational modifications of HOX proteins, an underestimated issue.
, 2018 Post-translational modifications (PTMs) are important determinants which contribute to modulating the turn-over, intracellular localisation, molecular interactions and activity of most eukaryotic proteins.
Bridoux, Laure +3 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Post-translational regulation of proteins in fruit ripening and quality development
Horticulture AdvancesFruit ripening and quality formation are complex biological processes governed by multiple layers of regulatory mechanisms, including transcriptional regulation, translational control, and post-translational modifications (PTMs).
Zhuo Gao +5 more
doaj +1 more source
Post-translational lipid modifications in Plasmodium parasites
, 2022 Most eukaryotic proteins undergo post-translational modifications (PTMs) that significantly alter protein properties, regulate diverse cellular processes and increase proteome complexity.
Tania De Koning-Ward (13096974) +2 more
core
Advanced Healthcare Materials, EarlyView.ART@PLGA@GH‐A microspheres are developed via microfluidic technology for intra‐articular delivery of artemisinin. The system remodels rheumatoid arthritis microenvironments by regulating metabolic and inflammatory disorders, reducing lactate‐driven histone lactylation and cellular senescence, while restoring cartilage homeostasis and protecting joint ...
Shijie Meng +10 more
wiley +1 more source
Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling [PDF]
, 2022 Proteome-wide measurements of protein turnover have largely ignored the impact of post-translational modifications (PTMs). To address this gap, we employ stable isotope labeling and mass spectrometry to measure the turnover of >120,000 peptidoforms ...
Chang, Yun-Chien +16 more
core +1 more source
Advanced Science, EarlyView.The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang +11 more
wiley +1 more source