Results 61 to 70 of about 43,191 (287)
Post-translational regulation of proteins in fruit ripening and quality development
Horticulture AdvancesFruit ripening and quality formation are complex biological processes governed by multiple layers of regulatory mechanisms, including transcriptional regulation, translational control, and post-translational modifications (PTMs).
Zhuo Gao +5 more
doaj +1 more source
CellsAndrogen receptor (AR) transcriptional activity significantly influences prostate cancer (PCa) progression. In addition to ligand stimulation, AR transcriptional activity is also influenced by a variety of post-translational modifications (PTMs).
Lance Edward V. Lumahan +3 more
doaj +1 more source
Post-Translational modifications and the effects on protein identification through mass spectrometry [PDF]
, 2005 only availableMass Spectrometry is an effective tool for protein identification. A typical process for protein identification is to break down a protein into smaller peptides and to determine the mass of each of these peptides.
Song, Zhao, 1978- +2 more
core
Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source
Identifying Protein Interactions with Histone Peptides Using Bio-layer Interferometry
Bio-Protocol, 2018 Histone post-translational modifications (PTMs) regulate numerous cellular processes, including gene transcription, cell division, and DNA damage repair. Most histone PTMs affect the recruitment or exclusion of reader proteins from chromatin.
Bingbing Ren +4 more
doaj +1 more source
Developmentally Regulated Post-translational Modification of Nucleoplasmin Controls Histone Sequestration and Deposition [PDF]
, 1928 SummaryNucleoplasmin (Npm) is an abundant histone chaperone in vertebrate oocytes and embryos. During embryogenesis, regulation of Npm histone binding is critical for its function in storing and releasing maternal histones to establish and maintain the ...
Onikubo, Takashi +11 more
core +2 more sources
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, EarlyView.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
Nature Communications, 2016 Many biopharmaceuticals exhibit mixed heterogeneity in their post-translational modifications (PTMs) that are essential for their function. Here the authors use a combination of mass spectrometry techniques to analyse human erythropoietin (EPO) and ...
Yang Yang +5 more
doaj +1 more source
System level dynamics of post-translational modifications [PDF]
, 2014 Attempts to characterize cellular behaviors with static, univariate measurements cannot fully capture biological complexity and lead to an inadequate interpretation of cellular processes.
Gajadhar, Aaron, White, Forest M.
core +1 more source
Amyloidogenic Peptide Fragments Designed From Bacterial Collagen‐like Proteins Form Hydrogel
Advanced Functional Materials, EarlyView.This study identified amyloidogenic sequence motifs in bacterial collagen‐like proteins and exploited these to design peptides that self‐assemble into β‐sheet fibers and form hydrogels. One hydrogel supported healthy fibroblast growth, showing promise for biocompatible materials. Our work demonstrates that bacterial sequences can be harnessed to create
Vamika Sagar +5 more
wiley +1 more source