Results 61 to 70 of about 27,453 (249)

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Unconventional protein post-translational modifications: the helmsmen in breast cancer

Cell & Bioscience, 2022
Breast cancer is the most prevalent malignant tumor and a leading cause of mortality among females worldwide. The tumorigenesis and progression of breast cancer involve complex pathophysiological processes, which may be mediated by post-translational ...
Jiena Liu, Qin Wang, Yujuan Kang, Shouping Xu, Da Pang   +4 more
doaj   +1 more source

Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis [PDF]

Cells, 2019
Liver fibrosis is characterized by the excessive deposition of extracellular matrix proteins including collagen that occurs in most types of chronic liver disease. Even though our knowledge of the cellular and molecular mechanisms of liver fibrosis has deeply improved in the last years, therapeutic approaches for liver fibrosis remain limited ...
Sofia Lachiondo-Ortega, Maria Mercado-Gómez, Marina Serrano-Maciá, Fernando Lopitz-Otsoa, Tanya B Salas-Villalobos, Marta Varela-Rey, Teresa C. Delgado, María Luz Martínez-Chantar   +7 more
openaire   +2 more sources

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

The Role of Protein Post-Translational Modifications in Fruit Ripening

Horticulturae
Fruit ripening represents a multifaceted biological process intricately controlled by an array of plant hormones, transcription factors, and epigenetic modifications.
Ting Li, Jing Zeng, Xinquan Yang, Pedro Garcia-Caparros, Xuewu Duan   +4 more
doaj   +1 more source

The role and mechanism of post-translational modifications (PTMs) in immune-related eye diseases

Experimental Eye Research
Post-translational modifications (PTMs) encompass the spectrum of chemical covalent alterations that proteins undergo after being synthesized from mRNA. These modifications typically involve the covalent bonding of chemical groups or small protein molecules to the amino acid backbones or side chains.
Yakun Wang, Xianyang Liu, Shuhao Zeng, Wenxian Yang, Fan Cao, Shengping Hou   +5 more
openaire   +2 more sources

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED
Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the pathogenesis of hematologic malignancies. This review synthesizes the latest research advances in the regulatory mechanisms, clinical relevance, and ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
doaj   +1 more source

The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications

Frontiers in Immunology
Histones play crucial roles in both promoting and repressing gene expression, primarily regulated through post-translational modifications (PTMs) at specific amino acid residues.
Xiaohong Duan, Xiaohong Duan, Xiaohong Duan, Zhiyao Xing, Zhiyao Xing, Zhiyao Xing, Lu Qiao, Shan Qin, Xuejing Zhao, Yanhua Gong, Yanhua Gong, Yanhua Gong, Xueren Li, Xueren Li   +13 more
doaj   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source