Results 41 to 50 of about 43,191 (287)
Protein Modifications as Potential Biomarkers in Breast Cancer
Biomarker Insights, 2009 A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry
Hongjun Jin, Richard C. Zangar
doaj +2 more sources
Frontiers in Molecular Neuroscience, 2021 Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic ...
Melanie J. Grubisha +3 more
doaj +1 more source
Roles of Post-translational Modifications in Spinocerebellar Ataxias
Frontiers in Cellular Neuroscience, 2018 Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, etc., of proteins can modulate protein properties such as intracellular distribution, activity, stability, aggregation, and interactions ...
Linlin Wan +14 more
doaj +1 more source
Frontiers in Microbiology, 2020 Throughout various stages of its life cycle, influenza A virus relies heavily on host cellular machinery, including the post-translational modifications (PTMs) system.
Jiao Hu +8 more
doaj +1 more source
Identification and Characterization of HTLV-1 HBZ Post-Translational Modifications [PDF]
, 2014 Human T-cell leukemia virus type-1 (HTLV-1) is estimated to infect 15–25 million people worldwide, with several areas including southern Japan and the Caribbean basin being endemic.
Al-Saleem, Jacob +5 more
core +6 more sources
Evolution and functional cross‐talk of protein post‐translational modifications
Molecular Systems Biology, 2013 Protein post‐translational modifications (PTMs) allow the cell to regulate protein activity and play a crucial role in the response to changes in external conditions or internal states.
Pedro Beltrao +3 more
doaj +1 more source
PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications [PDF]
Cell Biochemistry and Biophysics, 2011 Deubiquitinating enzymes (DUBs) constitute a diverse protein family and their impact on numerous biological and pathological processes has now been widely appreciated. Many DUB functions have to be tightly controlled within the cell, and this can be achieved in several ways, such as substrate-induced conformational changes, binding to adaptor proteins,
Kessler, B, Edelmann, M
openaire +2 more sources
Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis [PDF]
Cells, 2019 Liver fibrosis is characterized by the excessive deposition of extracellular matrix proteins including collagen that occurs in most types of chronic liver disease. Even though our knowledge of the cellular and molecular mechanisms of liver fibrosis has deeply improved in the last years, therapeutic approaches for liver fibrosis remain limited ...
Sofia Lachiondo-Ortega +7 more
openaire +3 more sources
Protein post-translational modifications: In silico prediction tools and molecular modeling
Computational and Structural Biotechnology Journal, 2017 Post-translational modifications (PTMs) occur in almost all proteins and play an important role in numerous biological processes by significantly affecting proteins' structure and dynamics.
Martina Audagnotto, Matteo Dal Peraro
doaj +1 more source
PTHGRN: unraveling post-translational hierarchical gene regulatory networks using PPI, ChIP-seq and gene expression data [PDF]
, 2014 Interactions among transcriptional factors (TFs), cofactors and other proteins or enzymes can affect transcriptional regulatory capabilities of eukaryotic organisms. Post-translational modifications (PTMs) cooperate with TFs and epigenetic alterations to
Boheler, KR +8 more
core +1 more source