Results 41 to 50 of about 43,903 (286)
Viruses, 2022 Post-translational regulation of proteins has emerged as a central topic of research in the field of functional proteomics. Post-translational modifications (PTMs) dynamically control the activities of proteins and are involved in a wide range of ...
Ramiro Garza-Domínguez +1 more
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Controllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family [PDF]
, 2016 Posttranslational regulation of protein function is an ubiquitous mechanism in eukaryotic cells. Here, we analyzed biological properties of nodes and edges of a human protein-protein interaction phosphorylation-based network, especially of those nodes ...
Bustos, Diego Martin +2 more
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PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications [PDF]
Cell Biochemistry and Biophysics, 2011 Deubiquitinating enzymes (DUBs) constitute a diverse protein family and their impact on numerous biological and pathological processes has now been widely appreciated. Many DUB functions have to be tightly controlled within the cell, and this can be achieved in several ways, such as substrate-induced conformational changes, binding to adaptor proteins,
Kessler, B, Edelmann, M
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Curcumin affects HSP60 folding activity and levels in neuroblastoma cells [PDF]
, 2020 The fundamental challenge in fighting cancer is the development of protective agents able to interfere with the classical pathways of malignant transformation, such as extracellular matrix remodeling, epithelial\u2013mesenchymal transition and ...
Campanella C. +9 more
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Proteome-wide profiling and mapping of post translational modifications in human hearts
Scientific Reports, 2021 Post translational modifications (PTMs) are covalent modifications of proteins that can range from small chemical modifications to addition of entire proteins.
Navratan Bagwan +2 more
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Recent advances in malaria genomics and epigenomics [PDF]
, 2016 Malaria continues to impose a significant disease burden on low- and middle-income countries in the tropics. However, revolutionary progress over the last 3 years in nucleic acid sequencing, reverse genetics, and post-genome analyses has generated step ...
Kirchner, Sebastian +2 more
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Mechanisms of SOD1 regulation by post-translational modifications
Redox Biology, 2019 SOD1 is commonly known for its ROS scavenging activity, but recent work has uncovered additional roles in modulating metabolism, maintaining redox balance, and regulating transcription.
C.J. Banks, J.L. Andersen
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Protein Modifications as Potential Biomarkers in Breast Cancer
Biomarker Insights, 2009 A variety of post-translational protein modifications (PTMs) are known to be altered as a result of cancer development. Thus, these PTMs are potentially useful biomarkers for breast cancer. Mass spectrometry, antibody microarrays and immunohistochemistry
Hongjun Jin, Richard C. Zangar
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Frontiers in Molecular Neuroscience, 2021 Gene expression and translation have been extensively studied in human post-mortem brain tissue from subjects with psychiatric disease. Post-translational modifications (PTMs) have received less attention despite their implication by unbiased genetic ...
Melanie J. Grubisha +3 more
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How many human proteoforms are there? [PDF]
, 2018 Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which
Aebersold, Ruedi +52 more
core +2 more sources