Results 1 to 10 of about 53,578 (248)

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome [PDF]

Advanced Science
A balanced SUMOylation equilibrium safeguards the functional anti‐tumor immune response. Oncogene activation drives SUMOylation, rendering aberrant SUMOylation a hallmark of cancer.
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
doaj   +2 more sources

EBNA1 SUMOylation by PIAS1 suppresses EBV lytic replication and enhances episome maintenance [PDF]

mBio
Epstein-Barr virus nuclear antigen 1 (EBNA1) is essential for the replication and stable maintenance of the viral episome in infected cells. Here, we identify the SUMO E3 ligase PIAS1 as a key regulator of EBNA1 through site-specific SUMOylation.
Febri Gunawan Sugiokto, Kun Zhang, Yunash Maharjan, Renfeng Li   +3 more
doaj   +2 more sources

Histone sumoylation and chromatin dynamics

Nucleic Acids Research, 2021
Abstract Chromatin structure and gene expression are dynamically controlled by post-translational modifications (PTMs) on histone proteins, including ubiquitylation, methylation, acetylation and small ubiquitin-like modifier (SUMO) conjugation.
Hong-Yeoul Ryu, Mark Hochstrasser
exaly   +3 more sources

RECENT ADVANCES IN POST-TRANSLATIONAL REGULATION OF PLANT DEFENSE RESPONSES BEYOND PHOSPHORYLATION [PDF]

Journal of Plant Development, 2021
During plant-microbe interactions, plant immune signaling relies significantly on post-translational modifications (PTMs) to induce rapid downstream changes.
Tim XING, Ziwei GUO
doaj   +1 more source

A Chemical and Enzymatic Approach to Study Site-Specific Sumoylation. [PDF]

, 2015
A variety of cellular pathways are regulated by protein modifications with ubiquitin-family proteins. SUMO, the Small Ubiquitin-like MOdifier, is covalently attached to lysine on target proteins via a cascade reaction catalyzed by E1, E2, and E3 enzymes.
Albuquerque, Claudio P, Corbett, Kevin D, Fu, Ting, Ma, Shawn, Yeung, Eyan, Zhou, Huilin   +5 more
core   +10 more sources

Host SUMOylation Pathway Negatively Regulates Protective Immune Responses and Promotes Leishmania donovani Survival

Frontiers in Cellular and Infection Microbiology, 2022
SUMOylation is one of the post-translational modifications that have recently been described as a key regulator of various cellular, nuclear, metabolic, and immunological processes.
Jhalak Singhal, Evanka Madan, Ayushi Chaurasiya, Pallavi Srivastava, Niharika Singh, Shikha Kaushik, Amandeep Kaur Kahlon, Mukesh Kumar Maurya, Manisha Marothia, Prerna Joshi, Anand Ranganathan, Shailja Singh   +11 more
doaj   +1 more source

SUMOylation Connects Cell Stress Responses and Inflammatory Control: Lessons From the Gut as a Model Organ

Frontiers in Immunology, 2021
Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-translational modification regulating the stability, activity, and subcellular localization of its target proteins.
Jörn Karhausen, Jörn Karhausen, Luis Ulloa, Wei Yang   +3 more
doaj   +1 more source

Sumoylation of the human histone H4 tail inhibits p300-mediated transcription by RNA polymerase II in cellular extracts

eLife, 2021
The post-translational modification of histones by the small ubiquitin-like modifier (SUMO) protein has been associated with gene regulation, centromeric localization, and double-strand break repair in eukaryotes.
Calvin Jon A Leonen, Miho Shimada, Caroline E Weller, Tomoyoshi Nakadai, Peter L Hsu, Elizabeth L Tyson, Arpit Mishra, Patrick MM Shelton, Martin Sadilek, R David Hawkins, Ning Zheng, Robert G Roeder, Champak Chatterjee   +12 more
doaj   +1 more source

Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]

PLoS ONE, 2012
Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su, Tsunghan Yang, Hoting Huang, Leroy F Liu, Jaulang Hwang   +4 more
doaj   +1 more source

Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling

Frontiers in Cell and Developmental Biology, 2022
The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling.
Jianhang Jia, Jin Jiang
doaj   +1 more source