Results 1 to 10 of about 30,796 (118)
SUMOylation modification-mediated cell death
Open Biology, 2021 SUMOylation dynamically conjugates SUMO molecules to the lysine residue of a substrate protein, which depends on the physiological state of the cell and the attached SUMO isoforms.
Ya-Nan Deng +2 more
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Protein SUMOylation modification and its associations with disease [PDF]
Open Biology, 2017 SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis.
Yanfang Yang, Hongxia Zhu, Ningzhi Xu
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RECENT ADVANCES IN POST-TRANSLATIONAL REGULATION OF PLANT DEFENSE RESPONSES BEYOND PHOSPHORYLATION [PDF]
Journal of Plant Development, 2021 During plant-microbe interactions, plant immune signaling relies significantly on post-translational modifications (PTMs) to induce rapid downstream changes.
Tim XING, Ziwei GUO
doaj +1 more source
eLife, 2021 The post-translational modification of histones by the small ubiquitin-like modifier (SUMO) protein has been associated with gene regulation, centromeric localization, and double-strand break repair in eukaryotes.
Calvin Jon A Leonen +12 more
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Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
Frontiers in Cell and Developmental Biology, 2022 The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling.
Jianhang Jia, Jin Jiang
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SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease [PDF]
Open Biology, 2017 Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of SUMOylation in the epithelial signalling in Crohn's disease (CD) and ulcerative ...
Salman Ahmad Mustfa +11 more
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Frontiers in Cell and Developmental Biology, 2021 Protein sumoylation is one of the most important post-translational modifications regulating many biological processes (Flotho A & Melchior F. 2013. Ann Rev. Biochem. 82:357–85).
Qian Nie +21 more
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The Role of Sumoylation in the Response to Hypoxia: An Overview
Cells, 2020 Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular response ...
Chrysa Filippopoulou +2 more
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Frontiers in Cellular and Infection Microbiology, 2022 SUMOylation is one of the post-translational modifications that have recently been described as a key regulator of various cellular, nuclear, metabolic, and immunological processes.
Jhalak Singhal +11 more
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Frontiers in Immunology, 2021 Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-translational modification regulating the stability, activity, and subcellular localization of its target proteins.
Jörn Karhausen +3 more
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