Results 1 to 10 of about 35,698 (247)
Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome [PDF]
Advanced ScienceA balanced SUMOylation equilibrium safeguards the functional anti‐tumor immune response. Oncogene activation drives SUMOylation, rendering aberrant SUMOylation a hallmark of cancer.
Uta M. Demel +19 more
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Protein SUMOylation modification and its associations with disease [PDF]
Open Biology, 2017 SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis.
Yanfang Yang, Gu He, Hongxia Zhu
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SUMOylation and de‐SUMOylation in response to DNA damage [PDF]
FEBS Letters, 2011 To maintain genomic integrity, a cell must utilize multiple mechanisms to protect its DNA from the damage generated by environmental agents or DNA metabolism. SUMO (small ubiquitin‐like modifier) can regulate protein stability, protein cellular location, and protein–protein interactions.
Dou, Hong +4 more
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PML, SUMOylation, and Senescence [PDF]
Frontiers in Oncology, 2013 Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues.
Hugues eDe Thé +10 more
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Sumoylation at the Host-Pathogen Interface
Biomolecules, 2012 Many viral proteins have been shown to be sumoylated with corresponding regulatory effects on their protein function, indicating that this host cell modification process is widely exploited by viral pathogens to control viral activity.
Van G. Wilson
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Extranuclear SUMOylation in Neurons [PDF]
Trends in Neurosciences, 2018 Post-translational modification of substrate proteins by SUMO conjugation regulates a diverse array of cellular processes. While predominantly a nuclear protein modification, there is a growing appreciation that SUMOylation of proteins outside the nucleus plays direct roles in controlling synaptic transmission, neuronal excitability, and adaptive ...
Jeremy M. Henley +2 more
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Human immunodeficiency virus type 1 impairs sumoylation
Life Science Alliance, 2022 The HIV type 1 dampens host cell sumoylation in vitro and reduces the expression of UBA2 protein, a subunit of the SUMO E1–activating enzyme. In vivo, infection in patients is associated with diminished global leukocyte sumoylation activity.
Bilgül Mete +7 more
doaj +2 more sources
Is Transthyretin a Regulator of Ubc9 SUMOylation? [PDF]
PLoS ONE, 2016 Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR.
Elżbieta Wieczorek +6 more
doaj +3 more sources
Predicting SUMOylation Sites [PDF]
, 2008 Recent evidence suggests that SUMOylation of proteins plays a key regulatory role in the assembly and dis-assembly of nuclear sub-compartments, and may repress transcription by modifying chromatin. Determining whether a protein contains a, SUMOylation site or not thus provides essential clues about a substrate's intra-nuclear spatial association and ...
Denis C. Bauer +2 more
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SUMOylation modification-mediated cell death
Open Biology, 2021 SUMOylation dynamically conjugates SUMO molecules to the lysine residue of a substrate protein, which depends on the physiological state of the cell and the attached SUMO isoforms.
Zenghua Sheng, Jing Zhu, Ya-Nan Deng
exaly +3 more sources