Results 11 to 20 of about 35,698 (247)
SUMOylation of claudin-2: SUMOylation of claudin-2 [PDF]
Annals of the New York Academy of Sciences, 2012 The C‐terminal cytoplasmic tails of claudins are likely sites for interaction with proteins that regulate their function. We performed a yeast two‐hybrid screen with the tail of human claudin‐2 against a human kidney cDNA library and identified interactions with the PDZ3 domain of ZO‐2 as well as ubiquitin‐conjugating enzyme E2I (SUMO ligase‐1) and E3 ...
Van Itallie, Christina M. +2 more
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SUMOylation Inhibitor TAK-981 Alleviates Hallmark Features of Preeclampsia Related to High Glucocorticoid Exposure by Inhibiting Placental Oxidative Stress in Rats [PDF]
AntioxidantsSUMOylation may be involved in preeclampsia (PE) progression. We aimed to investigate the roles of SUMOylation in PE and its underlying mechanism using animal and cell models. A rat PE model was established by dexamethasone (DEX) treatment from pregnancy
Shu Xiao +6 more
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A ZNF-nanobody fusion reveals SUMOylation-dependent changes in p53 protein localization [PDF]
iScienceSummary: SUMOylation is a post-translational modification regulating protein localization, stability, and activity, with effects varying depending on the conjugated SUMO protein and type of SUMOylation.
Antoine Y. Bouchard +8 more
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Ubc9 fusion-directed SUMOylation identifies constitutive and inducible SUMOylation [PDF]
Nucleic Acids Research, 2007 Constitutive and induced protein SUMOylation is involved in the regulation of a variety of cellular processes, such as regulation of gene expression and protein transport, and proceeds mainly in the nucleus of the cell. So far, several hundred SUMOylation targets have been identified, but presumably they represent only a part of the total of proteins ...
Jakobs, Astrid +5 more
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Sumoylation in Physiology, Pathology and Therapy
Cells, 2022 Sumoylation is an essential post-translational modification that has evolved to regulate intricate networks within emerging complexities of eukaryotic cells.
Umut Sahin +2 more
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, 2019 Protein regulation by reversible attachment of SUMO (small ubiquitin-related modifier) plays an important role in several cellular processes such as transcriptional regulation, nucleo-cytoplasmic transport, cell-cycle progression, meiosis, and DNA repair.
Breucker , J., Pichler, A.
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, 2008 Reversible attachment of SUMO (small ubiquitin related modifi er) regulates a large number of proteins and plays an important role in processes such as transcriptional regulation, nucleo-cytoplasmic transport, genome integrity, and cell cycle progression.
Pichler, A.
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EBNA1 SUMOylation by PIAS1 suppresses EBV lytic replication and enhances episome maintenance [PDF]
mBioEpstein-Barr virus nuclear antigen 1 (EBNA1) is essential for the replication and stable maintenance of the viral episome in infected cells. Here, we identify the SUMO E3 ligase PIAS1 as a key regulator of EBNA1 through site-specific SUMOylation.
Febri Gunawan Sugiokto +3 more
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RECENT ADVANCES IN POST-TRANSLATIONAL REGULATION OF PLANT DEFENSE RESPONSES BEYOND PHOSPHORYLATION [PDF]
Journal of Plant Development, 2021 During plant-microbe interactions, plant immune signaling relies significantly on post-translational modifications (PTMs) to induce rapid downstream changes.
Tim XING, Ziwei GUO
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Frontiers in Cellular and Infection Microbiology, 2022 SUMOylation is one of the post-translational modifications that have recently been described as a key regulator of various cellular, nuclear, metabolic, and immunological processes.
Jhalak Singhal +11 more
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