Results 11 to 20 of about 38,177 (201)

Human immunodeficiency virus type 1 impairs sumoylation

Life Science Alliance, 2022
The HIV type 1 dampens host cell sumoylation in vitro and reduces the expression of UBA2 protein, a subunit of the SUMO E1–activating enzyme. In vivo, infection in patients is associated with diminished global leukocyte sumoylation activity.
Bilgül Mete, Emre Pekbilir, Bilge Nur Bilge, Panagiota Georgiadou, Elif Çelik, Tolga Sutlu, Fehmi Tabak, Umut Sahin   +7 more
doaj   +2 more sources

Is Transthyretin a Regulator of Ubc9 SUMOylation? [PDF]

PLoS ONE, 2016
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR.
Elżbieta Wieczorek, Sylwia Kędracka-Krok, Katarzyna Sołtys, Urszula Jankowska, Rafał Hołubowicz, Justyna Seliga, Andrzej Ożyhar   +6 more
doaj   +3 more sources

Sumoylation at the Host-Pathogen Interface

Biomolecules, 2012
Many viral proteins have been shown to be sumoylated with corresponding regulatory effects on their protein function, indicating that this host cell modification process is widely exploited by viral pathogens to control viral activity.
Van G. Wilson
doaj   +2 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome [PDF]

Advanced Science
A balanced SUMOylation equilibrium safeguards the functional anti‐tumor immune response. Oncogene activation drives SUMOylation, rendering aberrant SUMOylation a hallmark of cancer.
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
doaj   +2 more sources

Sumoylation in Physiology, Pathology and Therapy

Cells, 2022
Sumoylation is an essential post-translational modification that has evolved to regulate intricate networks within emerging complexities of eukaryotic cells.
Umut Sahin, Hugues de Thé, Valérie Lallemand-Breitenbach   +2 more
doaj   +2 more sources

SIZ1-Mediated SUMOylation of LBD29 Recruits ARF7 to Fine-Tune Auxin Signaling in Lateral Root Development. [PDF]

Adv Sci (Weinh)
Our findings establish SUMOylation as a key post‐translational control layer in auxin signaling. We show that SIZ1‐mediated SUMOylation of LBD29 promotes its association with ARF7, stabilizing a transcriptional hub that governs lateral root development.
Sui J, Yin Q, Chen Y, Zhang L, Yu X, Yu Q, Ding Z, Kong X.   +7 more
europepmc   +2 more sources

SUMOylation controls the neurodevelopmental function of the transcription factor Zbtb20. [PDF]

, 2020
SUMOylation is a dynamic post-translational protein modification that primarily takes place in cell nuclei, where it plays a key role in multiple DNA-related processes.
Hellmann, Klaus Peter, Tirard, Marilyn, Nils Brose, Chowdhury, Kamal, Ripamonti, Silvia, Ripamonti, S., Marilyn Tirard, Chowdhury, K., Olaf Jahn, Hellmann, K., Jeong Seop Rhee, Shomroni, O., Klaus Peter Hellmann, Silvia Ripamonti, Tirard, M., Kamal Chowdhury, Bonn, S., Stefan Bonn, Orr Shomroni, Rhee, J., Bonn, Stefan, Rhee, Jeong Seop, Shomroni, Orr, Brose, Nils, Brose, N., Brose, N. ; https://orcid.org/, Jahn, Olaf, Jahn, O.   +27 more
core   +1 more source

A role for SUMO modification in transcriptional repression and activation [PDF]

, 2007
Since the discovery of the SUMO (small ubiquitin-related modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
Lyst, M J, Stancheva, I
core   +1 more source

Protein SUMOylation regulates insulin secretion at multiple stages [PDF]

, 2019
Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people.
Davey, Jeffrey S., Craig, Tim J., Carmichael, Ruth E.   +2 more
core   +1 more source

Protein Sumoylation Is Crucial for Phagocytosis in Entamoeba histolytica Trophozoites

, 2021
Posttranslational modifications provide Entamoeba histolytica proteins the timing and signaling to intervene during different processes, such as phagocytosis. However, SUMOylation has not been studied in E. histolytica yet.
Esther Orozco, Díaz-Hernández, Mitzi, Javier-Reyna, Rosario, García-Rivera, Guillermina, Abigail Betanzos, Dxinegueela Zanatta, Montaño, Sarita, Guillermina García-Rivera, Mitzi Díaz-Hernández, Zanatta, Dxinegueela, Rosario Javier-Reyna, Betanzo, Abigail, Sarita Montaño, Orozco, Esther, Sotto-Ortega, Izaid José, Izaid Sotto-Ortega   +15 more
core   +1 more source