Results 31 to 40 of about 35,698 (247)
Protein Sumoylation Is Crucial for Phagocytosis in Entamoeba histolytica Trophozoites
, 2021 Posttranslational modifications provide Entamoeba histolytica proteins the timing and signaling to intervene during different processes, such as phagocytosis. However, SUMOylation has not been studied in E. histolytica yet.
Esther Orozco +15 more
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The Role of Sumoylation in the Response to Hypoxia: An Overview
Cells, 2020 Sumoylation is the covalent attachment of the small ubiquitin-related modifier (SUMO) to a vast variety of proteins in order to modulate their function. Sumoylation has emerged as an important modification with a regulatory role in the cellular response ...
Chrysa Filippopoulou +2 more
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Frontiers in Cell and Developmental Biology, 2023 Background: Recent studies have revealed that SUMOylation modifications are involved in various biological processes, including cancer development and progression.
Zhike Chen +18 more
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Natural Products Against Renal Fibrosis via Modulation of SUMOylation
Frontiers in Pharmacology, 2022 Renal fibrosis is the common and final pathological process of kidney diseases. As a dynamic and reversible post-translational modification, SUMOylation and deSUMOylation of transcriptional factors and key mediators significantly affect the development ...
Peng Liu +5 more
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Sumoylation of Hes6 Regulates Protein Degradation and Hes1-Mediated Transcription [PDF]
Endocrinology and Metabolism, 2015 BackgroundHes6 is a transcriptional regulator that induces transcriptional activation by binding to transcription repressor Hes1 and suppressing its activity. Hes6 is controlled by the ubiquitin-proteosome-mediated degradation system.
Jiwon Lee +3 more
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SUMOylation and De-SUMOylation: Wrestling with Life's Processes [PDF]
Journal of Biological Chemistry, 2009 The small ubiquitin-like modifier (SUMO) is a ubiquitin-like protein that covalently modifies a large number of cellular proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization. SUMOylation is a dynamic process that is mediated by activating (E1), conjugating (E2), and ligating (E3) enzymes and
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SUMOylation represses Nanog expression via modulating transcription factors Oct4 and Sox2. [PDF]
PLoS ONE, 2012 Nanog is a pivotal transcription factor in embryonic stem (ES) cells and is essential for maintaining the pluripotency and self-renewal of ES cells. SUMOylation has been proved to regulate several stem cell markers' function, such as Oct4 and Sox2. Nanog
Yongyan Wu +10 more
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, 2020 Post-translational modifications are considered important molecular interactions in protein science. One of these modifications is “sumoylation” whose computational detection has recently become a challenge.
Reddy, Hamendra Manhar +3 more
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Analysis of PTP1B sumoylation [PDF]
Methods, 2014 Signaling enzymes are typically regulated by a variety of post-translational modifications. One such enzyme, protein tyrosine phosphatase (PTP) 1B, which plays an important role in metabolic and growth signaling, has recently been shown to be inhibited by posttranslational modifications by ubiquitin-related proteins of the SUMO family.
Sayanti, Saha, Jonathan, Chernoff
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Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast. [PDF]
PLoS ONE, 2009 Tec1 is a transcription factor in the yeast mitogen-activated protein kinase (MAPK) pathway that controls invasive growth. Previously we reported that a fraction of Tec1 protein is sumoylated on residue lysine 54 in normally growing cells.
Yuqi Wang +3 more
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