Results 41 to 50 of about 53,578 (248)

Host SUMOylation in bacterial infections and immune defense mechanisms

Frontiers in Microbiology
SUMOylation, the covalent attachment of small ubiquitin-like modifier proteins (SUMO) to lysine residues of target substrates, has emerged as a crucial post-translational modification regulating various cellular processes.
Yuhua Xu, Xi Ma, Zhifeng Wu, Ruitong Huang, Chenhua Liao, Di Huang, Yujun Tang, Chengbin Zhu, Yaqi Wang, Siyuan Zhang, Peng Liu, Jiaofeng Peng   +11 more
doaj   +1 more source

Post-translational Regulation of GLT-1 in Neurological Diseases and Its Potential as an Effective Therapeutic Target

Frontiers in Molecular Neuroscience, 2019
Glutamate transporter-1 (GLT-1) is a Na+-dependent transporter that plays a key role in glutamate homeostasis by removing excess glutamate in the central nervous system (CNS).
Allison R. Peterson, Devin K. Binder
doaj   +1 more source

Is Transthyretin a Regulator of Ubc9 SUMOylation? [PDF]

PLoS ONE, 2016
Ageing and mutations of transthyretin (TTR), the thyroid hormones and retinol transporting protein lead to amyloidosis by destabilizing the structure of TTR.
Elżbieta Wieczorek, Sylwia Kędracka-Krok, Katarzyna Sołtys, Urszula Jankowska, Rafał Hołubowicz, Justyna Seliga, Andrzej Ożyhar   +6 more
doaj   +1 more source

Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance [PDF]

, 2019
Chromatin is a highly regulated environment, and protein association with chromatin is often controlled by post-translational modifications and the corresponding enzymatic machinery.
Habermann, B., Hoepfler, M., Jentsch, S., Kern, M., Pfander, B., Prytuliak, R., Straub, T.   +6 more
core   +3 more sources

mRNA expression analysis of the SUMO pathway genes in the adult mouse retina

Biology Open, 2015
Sumoylation is a reversible post-translational modification that regulates different cellular processes by conjugation/deconjugation of SUMO moieties to target proteins.
Víctor Abad-Morales, Elena B. Domènech, Alejandro Garanto, Gemma Marfany   +3 more
doaj   +1 more source

Protein SUMOylation modification and its associations with disease [PDF]

Open Biology, 2017
SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis.
Yanfang Yang, Yu He, Xixi Wang, Ziwei liang, Gu He, Peng Zhang, Hongxia Zhu, Ningzhi Xu, Shufang Liang   +8 more
doaj   +1 more source

A novel human glucocorticoid receptor SNP results in increased transactivation potential. [PDF]

, 2017
Glucocorticoids are one of the most widely used therapeutics in the treatment of a variety of inflammatory disorders. However, it is known that there are variable patient responses to glucocorticoid treatment; there are responders and non-responders, or ...
Cho, Kiho, Green, Tajia L, Greenhalgh, David G, Leventhal, Stacey M, Lim, Debora, Tung, Kelly   +5 more
core   +3 more sources

Dynamic sumoylation of promoter-bound general transcription factors facilitates transcription by RNA polymerase II.

PLoS Genetics, 2021
Transcription-related proteins are frequently identified as targets of sumoylation, including multiple subunits of the RNA polymerase II (RNAPII) general transcription factors (GTFs).
Mohammad S Baig, Yimo Dou, Benjamin G Bergey, Russell Bahar, Justin M Burgener, Marjan Moallem, James B McNeil, Akhi Akhter, Giovanni L Burke, Veroni S Sri Theivakadadcham, Patricia Richard, Damien D'Amours, Emanuel Rosonina   +12 more
doaj   +1 more source

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

SUMOylation and NEDDylation in kidney diseases

Experimental and Molecular Pathology
Kidney disease poses a serious threat to human health and life, while the lack of specific therapeutic targets hinders the treatment of kidney disease.
Zi-Han Chen, Dan Li, Jian-Yu Zhang, Bo-Yu Wei, Hai-Ling Zhao, Ping Li, Dan-Qian Chen   +6 more
doaj   +1 more source