Results 61 to 70 of about 53,578 (248)

Proteotoxic stress reprograms the chromatin landscape of SUMO modification [PDF]

, 2015
The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins.
Anne Seifert, Geoffrey J. Barton, Pietà Schofield, Ronald T. Hay, Tanaka   +4 more
core   +3 more sources

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Correlation between serum SUMO1 level and hypertriglyceridemia in type 2 diabetes mellitus patients

Shanghai Jiaotong Daxue xuebao. Yixue ban
Objective·To explore the correlation between serum small ubiquitin-like modifier 1 (SUMO1) levels and hypertriglyceridemia in patients with type 2 diabetes mellitus (T2DM).Methods·A total of 239 newly diagnosed T2DM patients were recruited from the ...
ZHANG Xinyan, LI Han, RAN Hui, SU Qing, ZHANG Hongmei   +4 more
doaj   +1 more source

Geminiviral protein Rep interferes in PCNA sumoylation [PDF]

, 2015
Rep is a multifunctional protein essential for replication of geminivirus that interferes with the sumoylation of a key protein in the DNA replication, PCNA (Proliferating Cell Nuclear Antigen).
Arroyo-Mateos, Manuel, Bejarano, Eduardo R., Sabarit, Blanca, Sánchez-Durán, Miguel A.   +3 more
core  

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels. [PDF]

, 2020
Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia induces rapid SUMOylation of NaV1.5 channels so they reopen when normally inactive, late in the ...
Dai, Hui, Goldstein, Steve AN, Plant, Leigh D, Romero, Jesus, Xiong, Dazhi   +4 more
core  

SUMOylation and cell signalling

Biotechnology Journal, 2009
AbstractSUMOylation is a highly transient post‐translational protein modification. Attachment of SUMO to target proteins occurs via a number of specific activating and ligating enzymes that form the SUMO‐substrate complex, and other SUMO‐specific proteases that cleave the covalent bond, thus leaving both SUMO and target protein free for the next round ...
Andreou, Artemisia M., Tavernarakis, Nektarios   +1 more
openaire   +3 more sources

SUMOylation of nuclear actin [PDF]

Journal of Cell Biology, 2009
Actin, a major component of the cytoplasm, is also abundant in the nucleus. Nuclear actin is involved in a variety of nuclear processes including transcription, chromatin remodeling, and intranuclear transport. Nevertheless, the regulation of nuclear actin by posttranslational modifications has not been investigated.
Hofmann, Wilma A., Arduini, Alessandro, Nicol, Samantha M., Camacho, Carlos J., Lessard, James L., Fuller-Pace, Frances V., de Lanerolle, Primal   +6 more
openaire   +3 more sources

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source

SUMOylation is essential for Sirt2 tumor-suppressor function in neuroblastoma

Neoplasia: An International Journal for Oncology Research, 2021
SUMOylation is an important post-translational modification that participates in a variety of cellular physiological and pathological processes in eukaryotic cells. Sirt2, a NAD+-dependent deacetylase, usually exerts a tumor-suppressor function. However,
Wenmei Lu, Qian Wang, Ci Xu, Haihua Yuan, Qiang Fan, Biying Chen, Renjie Cai, Danhong Wu, Ming Xu   +8 more
doaj   +1 more source

S100A14 in Tumor‐Derived EVs Targets PIAS3 to Reprogram Astrocytes and Induce Immunosuppressive Microenvironment Promoting Brain Metastasis and Germacrone Reversal Effect

Advanced Science, EarlyView.
This study identifies S100A14 in tumor‐derived exosomes as a key driver of brain metastasis. S100A14 targets PIAS3 in astrocytes, activating STAT3 signaling and promoting immunosuppressive MDSCs recruitment via chemokine secretion. Germacrone, a natural compound, binds S100A14 to disrupt this axis, effectively inhibiting brain metastasis with low ...
Qian Feng, Xia Yang, Lin An, Xue‐Yu Wang, Ming‐Rui Wang, Zhuo‐Hong Cai, Cai‐Jun Xie, Li‐Jun Qiao, You‐Bi Shen, Xi‐Min Liang, Rong Zhang, Cai‐Yan Wang, Zhong‐Qiu Liu, Rong‐Rong Zhang   +13 more
wiley   +1 more source