Results 71 to 80 of about 38,177 (201)
Mycobacteria modulate SUMOylation to suppresses protective responses in dendritic cells.
PLoS ONE, 2023 Post translational modifications (PTMs) are exploited by various pathogens in order to escape host immune responses. SUMOylation is one of the PTMs which is involved in regulation of a variety of cellular responses.
Vandana Anang +7 more
doaj +1 more source
Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity
Advanced Science, EarlyView.Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen +17 more
wiley +1 more source
Advanced Science, EarlyView.The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian +14 more
wiley +1 more source
SUMOylation atypique du récepteur nucléaire Nor-1 [PDF]
, 2015 Les récepteurs nucléaires sont des facteurs de transcription régulant l’expression de gènes impliqués dans plusieurs processus physiologiques. En général, ces récepteurs sont activés par une interaction avec un ligand spécifique, mais leur activité peut ...
Gagnon, Jonathan
core
KSHV ORF45 facilitates RSK1 SUMOylation.
, 2022 (A) KSHV ORF45 enhances RSK1 SUMOylation. Individual KSHV encoded gene or vector control was co-expressed with HA-RSK1 and denatured immunoprecipitation (IP) and immunoblot (IB) were performed at 48 h post-transfection. The band intensities of SUMOylated
Zhenshan Liu (147780) +12 more
core +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
SUMOylation: A Link to Future Therapeutics
, 2015 SUMOylation, much of a similar process like ubiquitination catches attention across various research groups as a potential therapeutic target to fight various infectious and cancerous diseases.
Chun-Jie Huang +4 more
core +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
Solo or in Concert: SUMOylation in Pathogenic Fungi [PDF]
The Plant Pathology JournalSUMOylation plays a pivotal role in DNA replication and repair, transcriptional stability, and stress response. Although SUMOylation is a conserved post-translational modification (PTM) in eukaryotes, the number, type, and function of SUMOylation ...
You-Jin Lim, Yong-Hwan Lee
doaj +1 more source
TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu +8 more
wiley +1 more source