Results 91 to 100 of about 35,698 (247)
SUMOylation: A Link to Future Therapeutics
, 2015 SUMOylation, much of a similar process like ubiquitination catches attention across various research groups as a potential therapeutic target to fight various infectious and cancerous diseases.
Chun-Jie Huang +4 more
core +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
AaSIZ1-Mediated SUMOylation of AaMYB31 Positively Regulates Freezing Tolerance in Actinidia arguta. [PDF]
Plant Biotechnol JABSTRACT Several studies revealed that wax accumulation enhances plant tolerance to cold stress. However, the molecular regulation mechanism of wax synthesis under cold stress is still unclear in Actinidia arguta, a hardy kiwifruit species. Here, we found that cold stress significantly induces wax accumulation in Actinidia arguta leaves, which is ...
Liu L +16 more
europepmc +2 more sources
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source
, 2005 Group III presynaptic metabotropic glutamate receptors (mGluRs) play a central role in regulating presynaptic activity through G-protein effects on ion channels and signal transducing enzymes.
Tang, Z., Tang, Zhongshu
core
Proteins examined for sumoylation.
, 2013 Proteins examined for sumoylation.
Dana Branzei (237743) +4 more
core +1 more source
International audienceNeurofibromin (Nf1) is a giant multidomain protein encoded by the tumour-suppressor gene NF1. NF1 is mutated in a common genetic disease, neurofibromatosis type I (NF1), and in various cancers.
Mosrin-Huaman, Christine +13 more
core +3 more sources
A Comprehensive Review of the Genetic Etiology and Management of Orofacial Clefts
Pediatric Discovery, EarlyView.ABSTRACT Cleft lip (CL) and cleft palate (CP), collectively referred to as orofacial clefts (OFCs), are among the most common birth defects and can have significant effects on speech, nutrition, and physical and psychosocial development. Manifestation, classification, and treatment plans of OFCs are diverse and not standardized.
Emily Kim +3 more
wiley +1 more source
SUMOylation in Human Pathogenic Fungi: Role in Physiology and Virulence
Journal of Fungi, 2020 The small ubiquitin-related modifier (SUMO) protein is an important component of the post-translational protein modification systems in eukaryotic cells.
Mahima Sagar Sahu +3 more
doaj +1 more source