Results 91 to 100 of about 53,578 (248)

Smc5/6: a link between DNA repair and unidirectional replication? [PDF]

, 2008
Of the three structural maintenance of chromosome (SMC) complexes, two directly regulate chromosome dynamics. The third, Smc5/6, functions mainly in homologous recombination and in completing DNA replication.
A Losada, Antony M. Carr, AR Lehmann, B Hu, D Branzei, D Ivanov, DM Sheedy, E Ampatzidou, E Unal, E Unal, EA Andrews, ES Chen, F Onoda, G De Piccoli, GJ Cost, H Morikawa, HB Lindroos, HM Verkade, I Miyabe, J Palecek, J Rouse, J Sergeant, J Torres-Rosell, J Torres-Rosell, JK Chin, Johanne M. Murray, KL Borden, KM Lee, L Strom, L Strom, MI Fousteri, MN Boddy, N Aono, PR Potts, PR Potts, PR Potts, S Pebernard, S Pebernard, SH Harvey, T de Lange, T Kobayashi, T Mengiste, T Morishita, TM Roberts, WH McDonald, WM Thorburn, X Zhao   +46 more
core   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Srs2 promotes synthesis-dependent strand annealing by disrupting DNA polymerase δ-extending D-loops. [PDF]

, 2017
Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity.
Ede, Christopher, Freudenthal, Bret D, Gore, Steven K, Heyer, Wolf-Dietrich, Jenkins, Shirin S, Liu, Jie, Todd Washington, M, Veaute, Xavier, Wright, William D   +8 more
core   +3 more sources

SUMOylation in Trypanosoma brucei

PeerJ, 2013
Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress.
Cornelia Andrea Klein, Dorothea Droll, Christine Clayton   +2 more
openaire   +3 more sources

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

Novel post-translational modifications in bone remodeling: potential therapeutic strategies for osteoporosis

European Cells & Materials
Osteoblast-induced bone formation and osteoclast-mediated bone resorption coordinate the balance of bone remodeling. However, the exact mechanisms underlying bone remodeling remain unknown.
ZJ Pan, HH Liu, LY Liu, QZ Wang, J Pan
doaj   +1 more source

The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review

Stem Cells International, 2020
Malignant tumors still pose serious threats to human health due to their high morbidity and mortality. Recurrence and metastasis are the most important factors affecting patient prognosis.
Qi Zhao, Ying Ma, Zugui Li, Kexin Zhang, Minying Zheng, Shiwu Zhang   +5 more
doaj   +1 more source

Mycobacteria modulate SUMOylation to suppresses protective responses in dendritic cells.

PLoS ONE, 2023
Post translational modifications (PTMs) are exploited by various pathogens in order to escape host immune responses. SUMOylation is one of the PTMs which is involved in regulation of a variety of cellular responses.
Vandana Anang, Aayushi Singh, Ankush Kumar Rana, Shakuntala Surender Kumar Saraswati, Upasana Bandyopadhyay, Chaitenya Verma, Attinder Chadha, Krishnamurthy Natarajan   +7 more
doaj   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Geminivirus replication protein decreases PCNA sumoylation at two acceptor sites [PDF]

, 2019
Geminiviruses are plant viruses with circular, single-stranded DNA (ssDNA) genomes that infect a broad range of plants causing substantial crop diseases worldwide.
Arroyo-Mateos, Manuel, Bejarano, Eduardo R., Burg, Harrold A. van den, Luna, Ana P., Maio, Francesca, Prins, Marcel, Rosas-Díaz, Tábata, Ruiz-Albert, Francisco Javier, SABARIT, BLANCA, Sánchez-Durán, Miguel   +9 more
core