Results 111 to 120 of about 38,177 (201)

RING E3 ligase SNIPER8 functions redundantly with three close homologs to regulate the turnover of transcriptional co‐repressor TPR1

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis E3 ligase SNIPER8 negatively regulates immunity by promoting ubiquitination and proteasomal degradation of the transcriptional corepressor TOPLESS‐RELATED1, limiting excessive immune responses, maintaining immune homeostasis, and balancing defense activation and normal plant growth.
Xueru Liu, Paul Kapos, Zhongshou Wu, Yujun Peng, Meixuezi Tong, Asana Khajavi, Yan Huang, Yuelin Zhang, Xin Li   +8 more
wiley   +1 more source

Sumoylation inhibits CBS activity.

, 2013
aIn vitro sumoylation of CBS was performed as described under Methods.bThe activity remaining after 6 h of incubation needed for the sumoylation reaction is reported relative to the average of the CBS and CBS+hPc2 assay mixtures (169 µmol h−1 mg−1).
Nitish Agrawal (105325), Ruma Banerjee (45954)   +1 more
core   +1 more source

Mutations in SUMO conjugating enzyme reveal contributions of sumoylation to plant stress resilience and yield

New Phytologist, EarlyView.
Mutations in small ubiquitin‐related modifier (SUMO) conjugating enzyme that increase or decrease functionality reveal SUMO contributions to growth and stress resilience. Summary Small ubiquitin‐related modifier (SUMO) conjugation is a fundamental process in all metazoa, with multiple roles in development and stress responses.
Lilian Nehlin, Sadia Sabrina Alam, Junaid Shehzad, Bushra Ijaz, Jose Julián, Nikola Winter, Andreas Bachmair   +6 more
wiley   +1 more source

Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia

Oral Diseases, EarlyView.
ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio, Divya Ganesh, Bishwa Prakash Bhattarai, Tine Merete Søland, Jonas Sundberg, Annika Thorsell, Jenny Öhman, Dipak Sapkota, Bengt Hasséus   +8 more
wiley   +1 more source

SIZ1 and ESD4 Mediate The Reversible SUMOylation of SnRK2.6 Through Direct Physical Interaction

Shengwu huaxue yu shengwu wuli jinzhan
ObjectiveTo investigate the novel post-translational modifications (PTMs) of SnRK2.6, a central component in the abscisic acid (ABA) signaling pathway, such as SUMOylation, and to establish a foundation for revealing the physiological functions and ...
FU Huan-Huan, WEI Jian, LI Meng-Yao, HAN Yong-Feng   +3 more
doaj   +1 more source

Porphyromonas gingivalis GroEL accelerates abdominal aortic aneurysm formation by matrix metalloproteinase‐2 SUMOylation in vascular smooth muscle cells: A novel finding for the activation of MMP‐2

Molecular Oral Microbiology, EarlyView.
Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin, Feng‐Yen Lin, Ze‐Hao Lai, Chien‐Sung Tsai, Yi‐Ting Tsai, Yen‐Sung Huang, Chen‐Wei Liu   +6 more
wiley   +1 more source

Identification of Substrates of Protein-Group SUMOylation

, 2016
Protein modification by conjugation to the ubiquitin-related protein SUMO (SUMOylation) regulates numerous cellular functions and is reversible. However, unlike typical posttranslational modifications, SUMOylation often targets and regulates proteins of ...
Psakhye, I., Jentsch, S., Ivan Psakhye, Stefan Jentsch   +3 more
core   +1 more source

Design Principles of Plant Thermotolerance: Integrating Photosynthesis, Reproduction, and Field Resilience in a Warming Climate

Plant, Cell &Environment, EarlyView.
ABSTRACT Global food security is increasingly threatened by climate change, as rising temperatures compromise the yields of major staple crops, including wheat, rice, and maize. Enhancing plant thermotolerance has therefore become a critical priority for sustaining agricultural productivity.
Yuchen Qu, Wataru Yamori
wiley   +1 more source

SUMOylation Inhibitor TAK-981 Alleviates Hallmark Features of Preeclampsia Related to High Glucocorticoid Exposure by Inhibiting Placental Oxidative Stress in Rats

Antioxidants
SUMOylation may be involved in preeclampsia (PE) progression. We aimed to investigate the roles of SUMOylation in PE and its underlying mechanism using animal and cell models. A rat PE model was established by dexamethasone (DEX) treatment from pregnancy
Shu Xiao, Youyi Zhang, Zhengshan Tang, Caiyun Chen, Dewei Guo, Jing Long, Xin Ni   +6 more
doaj   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source