Results 131 to 140 of about 38,177 (201)

Hippo Pathway–YAP/TAZ Signaling: Molecular Mechanisms, Biological Function, Diseases, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
The Hippo–YAP/TAZ–TEAD pathway integrates mechanical and biochemical cues to govern organ growth, regeneration, cancer, and fibrosis. This review dissects pathway physiology, TEAD structural pharmacology and ligandable pockets, and therapeutic strategies spanning palmitoylation‐pocket inhibitors, PROTAC degraders, and gene/RNA therapies, highlighting ...
Xiaodan Qu, Zhan‐you Wang
wiley   +1 more source

TRIM28 Increases RFC4 Protein Expression to Promote Triple‐Negative Breast Cancer Progression

MedComm, Volume 7, Issue 10, October 2026.
RFC4 dysregulation has been implicated in tumor progression and poor prognosis across multiple cancer types. Triple‐negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited therapeutic options and unfavorable clinical outcomes, highlighting the need to identify effective therapeutic targets.
Cheng Guo, Li Liu, Lixiang Sun, Litong Liu, Han Wei, Yutong Yan, Fei Yu, Guangming Fu, Xianning Dong, Ceshi Chen, Chengqin Wang   +10 more
wiley   +1 more source

Mitochondrial Fusion and Fission in Age‐Related Cardio‐Cerebral Diseases: Mechanisms and Interventions

Aging Cell, Volume 25, Issue 10, October 2026.
Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley   +1 more source

The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis

Biology of the Cell, Volume 118, Issue 10, October 2026.
We highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases. ABSTRACT Lamin A is a major contributor to nuclear mechanics
Sandrine Fraboulet, Omar Aldarawish, Monika Elzbieta Dolega   +2 more
wiley   +1 more source

Identification of the Sumoylation Sites of Daxx

, 2004
SUMO (small ubiquitin-like modifier) protein, also known as Smt3 (suppressor of Mif2 protein 3) of Saccharomyces cerevisiae is an ubiquitin-like protein due to the similar post-transcriptional modifications to their substrates. There are three members of
Huang, Yi-hsin
core  

Hormone therapy potentiates chemoimmunotherapy by inducing SUMOylation-mediated immunogenic cell death. [PDF]

J Immunother Cancer
Li J, Liu M, Wei C, Zhou Y, Wen N, Li J, Zhao Q.   +6 more
europepmc   +1 more source

Reorientation of the SUMOylation landscape and altered L3mbtl2-mediated transcriptional activity in cancer-associated muscle contractile dysfunction. [PDF]

Cell Death Discov
Gand LV, Li M, Brandt K, Zhou B, Nassar-Grioua A, Gondin J, Becker E, Pich A, Kraft T, Amrute-Nayak M, Nayak A.   +10 more
europepmc   +1 more source

A RAC1 SUMOylation switch governs breast cancer metastasis. [PDF]

Signal Transduct Target Ther
García-Casas A, Martínez-López A, García-Sancha N, Corchado-Cobos R, Martín-Cabrera P, Salvador N, Lorente M, Sánchez-Martín MA, Mendiburu-Eliçabe M, González-Villar R, Velasco G, Clarke RB, Malliri A, Pérez-Losada J, Castillo-Lluva S.   +14 more
europepmc   +1 more source

In Vivo and In Vitro SUMOylation Assays in <i>Arabidopsis</i>. [PDF]

Bio Protoc
Liu X, Tang S, Guo X, Fan C, Hu Z.
europepmc   +1 more source

Analysis of Sumoylation

, 2008
Reversible attachment of SUMO (small ubiquitin related modifi er) regulates a large number of proteins and plays an important role in processes such as transcriptional regulation, nucleo-cytoplasmic transport, genome integrity, and cell cycle progression.
Pichler, A.
core