Results 21 to 30 of about 35,698 (247)
Frontiers in Immunology, 2021 Conjugation with the small ubiquitin-like modifier (SUMO) constitutes a key post-translational modification regulating the stability, activity, and subcellular localization of its target proteins.
Jörn Karhausen +3 more
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eLife, 2021 The post-translational modification of histones by the small ubiquitin-like modifier (SUMO) protein has been associated with gene regulation, centromeric localization, and double-strand break repair in eukaryotes.
Calvin Jon A Leonen +12 more
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Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
doaj +1 more source
Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
Frontiers in Cell and Developmental Biology, 2022 The GPCR-family protein Smoothened (Smo) is essential for Hedgehog (Hh) signal transduction in both insects and vertebrates. The regulation of subcellular localization and abundance of Smo is a critical step in Hh signaling.
Jianhang Jia, Jin Jiang
doaj +1 more source
Analysis of human cytomegalovirus-encoded SUMO targets and temporal regulation of SUMOylation of the immediate-early proteins IE1 and IE2 during infection. [PDF]
PLoS ONE, 2014 Post-translational modification of proteins by members of the small ubiquitin-like modifier (SUMO) is involved in diverse cellular functions. Many viral proteins are SUMO targets and also interact with the cellular SUMOylation system.
Eui Tae Kim +5 more
doaj +1 more source
SUMOylation controls the neurodevelopmental function of the transcription factor Zbtb20. [PDF]
, 2020 SUMOylation is a dynamic post-translational protein modification that primarily takes place in cell nuclei, where it plays a key role in multiple DNA-related processes.
Hellmann, Klaus Peter +27 more
core +1 more source
SUMOylation pathway alteration coupled with downregulation of SUMO E2 enzyme at mucosal epithelium modulates inflammation in inflammatory bowel disease [PDF]
Open Biology, 2017 Post-translational modification pathways such as SUMOylation are integral to all cellular processes and tissue homeostasis. We investigated the possible involvement of SUMOylation in the epithelial signalling in Crohn's disease (CD) and ulcerative ...
Salman Ahmad Mustfa +11 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 Protein sumoylation is one of the most important post-translational modifications regulating many biological processes (Flotho A & Melchior F. 2013. Ann Rev. Biochem. 82:357–85).
Qian Nie +21 more
doaj +1 more source
Protein SUMOylation regulates insulin secretion at multiple stages [PDF]
, 2019 Type-II Diabetes Mellitus (T2DM) is one of the fastest growing public health issues of modern times, consuming 12% of worldwide health budgets and affecting an estimated 400 million people.
Davey, Jeffrey S. +2 more
core +1 more source
A role for SUMO modification in transcriptional repression and activation [PDF]
, 2007 Since the discovery of the SUMO (small ubiquitin-related modifier) family of proteins just over a decade ago, a plethora of substrates have been uncovered including many regulators of transcription.
Lyst, M J, Stancheva, I
core +1 more source