Results 11 to 20 of about 43,191 (287)

Control of protein stability by post-translational modifications

Nature Communications, 2023
Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee, Henrik M. Hammarén, Mikhail M. Savitski, Sung Hee Baek   +3 more
doaj   +2 more sources

Dual Regulation of Post-Translational Modification of Proteins: Bottlenecks and Breakthroughs in NK Cell Therapy for Glioblastoma [PDF]

International Journal of General Medicine
Yushu Liu, Qingya Qiu, Hui Deng, Ping Song, Jiarui Bu, Mengxian Zhang Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of ChinaCorrespondence: Mengxian Zhang,
Liu Y, Qiu Q, Deng H, Song P, Bu J, Zhang M   +5 more
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The Burden of Post-Translational Modification (PTM)—Disrupting Mutations in the Tumor Matrisome [PDF]

Cancers, 2021
Background: To evaluate the occurrence of mutations affecting post-translational modification (PTM) sites in matrisome genes across different tumor types, in light of their genomic and functional contexts and in comparison with the rest of the genome.
Elisa Holstein, Annalena Dittmann, Anni Kääriäinen, Vilma Pesola, Jarkko Koivunen, Taina Pihlajaniemi, Alexandra Naba, Valerio Izzi   +7 more
openaire   +3 more sources

Post-translational modifications and their implications in cancer

Frontiers in Oncology, 2023
Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Hashnu Dutta, Hashnu Dutta, Nishant Jain, Nishant Jain   +3 more
doaj   +1 more source

Mass spectrometry-based direct detection of multiple types of protein thiol modifications in pancreatic beta cells under endoplasmic reticulum stress

Redox Biology, 2021
Thiol-based post-translational modifications (PTMs) play a key role in redox-dependent regulation and signaling. Functional cysteine (Cys) sites serve as redox switches, regulated through multiple types of PTMs.
Xiaolu Li, Nicholas J. Day, Song Feng, Matthew J. Gaffrey, Tai-Du Lin, Vanessa L. Paurus, Matthew E. Monroe, Ronald J. Moore, Bin Yang, Ming Xian, Wei-Jun Qian   +10 more
doaj   +1 more source

Special Issue “Structure, Activity, and Function of Protein Methyltransferases”

Life, 2022
Post-translational modifications (PTMs) largely expand the functional diversity of the proteome [...]
Arunkumar Dhayalan, Albert Jeltsch
doaj   +1 more source

Protein PTMs: post‐translational modifications or pesky trouble makers? [PDF]

Journal of Mass Spectrometry, 2010
AbstractAnalysis of protein post‐translational modifications using mass spectrometry is an intensive area of proteomic research. This perspective discusses the current state of the field with respect to what can be achieved, the challenges encountered, most notably with modification site assignment, the reliability of the published results ...
Ralph A, Bradshaw, Katalin F, Medzihradszky, Robert J, Chalkley   +2 more
openaire   +2 more sources

PTMViz: a tool for analyzing and visualizing histone post translational modification data

BMC Bioinformatics, 2021
Background Histone post-translational modifications (PTMs) play an important role in our system by regulating the structure of chromatin and therefore contribute to the regulation of gene and protein expression. Irregularities in histone PTMs can lead to
Kevin Chappell, Stefan Graw, Charity L. Washam, Aaron J. Storey, Chris Bolden, Eric C. Peterson, Stephanie D. Byrum   +6 more
doaj   +1 more source

Networking of predicted post-translational modification (PTM) sites in human EGFR [PDF]

Bioinformation, 2019
Epidermal growth factor receptor (EGFR) binds to EGF activating tyrosine phosphorylation through receptor dimerization prompting uncontrolled multiplication. Domain organization, secondary structure combinations in motifs and interactome define such transitory changes responsible for the multi-functionality of human EGFR.
Malik, Arshi, Afaq, Sarah, Alwabli, Afaf S, Al-ghmady, Khalid   +3 more
openaire   +2 more sources

Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation

Frontiers in Neurology, 2021
Post-translational modifications (PTMs) on tau have long been recognized as affecting protein function and contributing to neurodegeneration. The explosion of information on potential and observed PTMs on tau provides an opportunity to better understand ...
Carolina Alquezar, Shruti Arya, Aimee W. Kao   +2 more
doaj   +1 more source