Antioxidant systems are regulated by nitric oxide-mediated post-translational modifications (NO-PTMs) [PDF]
Frontiers in Plant Science, 2016 Nitric oxide (NO) is a biological messenger that orchestrates a plethora of plant functions, mainly through post-translational modifications (PTMs) such as S-nitrosylation or tyrosine nitration.
Juan Carlos Begara-Morales +7 more
doaj +4 more sources
Role of Host-Mediated Post-Translational Modifications (PTMs) in RNA Virus Pathogenesis. [PDF]
Int J Mol Sci, 2020 Being opportunistic intracellular pathogens, viruses are dependent on the host for their replication. They hijack host cellular machinery for their replication and survival by targeting crucial cellular physiological pathways, including transcription, translation, immune pathways, and apoptosis.
Kumar R +4 more
europepmc +4 more sources
The Burden of Post-Translational Modification (PTM)—Disrupting Mutations in the Tumor Matrisome [PDF]
Cancers, 2021 Background: To evaluate the occurrence of mutations affecting post-translational modification (PTM) sites in matrisome genes across different tumor types, in light of their genomic and functional contexts and in comparison with the rest of the genome.
Elisa Holstein +7 more
openaire +3 more sources
Analysis of STAT3 post-translational modifications (PTMs) in human prostate cancer with different Gleason Score. [PDF]
Oncotarget, 2017 Prostate Cancer (PCa) is a complex and heterogeneous disease. The androgen receptor (AR) and the signal transducer and activator of transcription 3 (STAT3) could be effective targets for PCa therapy. STAT3, a cytoplasmatic latent transcription factor, is a hub protein for several oncogenic signalling pathways and up-regulates the expression of numerous
Cocchiola R +10 more
europepmc +4 more sources
Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation. [PDF]
Mol Cell Proteomics, 2016 Histones are abundant chromatin constituents carrying numerous post-translational modifications (PTMs). Such PTMs mediate a variety of biological functions, including recruitment of enzymatic readers, writers and erasers that modulate DNA replication, transcription and repair. Individual histone molecules contain multiple coexisting PTMs, some of which
Schwämmle V +6 more
europepmc +5 more sources
Current Technologies Unraveling the Significance of Post-Translational Modifications (PTMs) as Crucial Players in Neurodegeneration. [PDF]
BiomoleculesNeurodegenerative disorders, such as Parkinson’s disease, Alzheimer’s disease, and Huntington’s disease, are identified and characterized by the progressive loss of neurons and neuronal dysfunction, resulting in cognitive and motor impairment.
Zafar S, Fatima SI, Schmitz M, Zerr I.
europepmc +6 more sources
Protein PTMs: post‐translational modifications or pesky trouble makers? [PDF]
Journal of Mass Spectrometry, 2010 AbstractAnalysis of protein post‐translational modifications using mass spectrometry is an intensive area of proteomic research. This perspective discusses the current state of the field with respect to what can be achieved, the challenges encountered, most notably with modification site assignment, the reliability of the published results ...
Ralph A, Bradshaw +2 more
openaire +2 more sources
PTMViz: a tool for analyzing and visualizing histone post translational modification data
BMC Bioinformatics, 2021 Background Histone post-translational modifications (PTMs) play an important role in our system by regulating the structure of chromatin and therefore contribute to the regulation of gene and protein expression. Irregularities in histone PTMs can lead to
Kevin Chappell +6 more
doaj +1 more source
Networking of predicted post-translational modification (PTM) sites in human EGFR [PDF]
Bioinformation, 2019 Epidermal growth factor receptor (EGFR) binds to EGF activating tyrosine phosphorylation through receptor dimerization prompting uncontrolled multiplication. Domain organization, secondary structure combinations in motifs and interactome define such transitory changes responsible for the multi-functionality of human EGFR.
Malik, Arshi +3 more
openaire +2 more sources
Frontiers in Neurology, 2021 Post-translational modifications (PTMs) on tau have long been recognized as affecting protein function and contributing to neurodegeneration. The explosion of information on potential and observed PTMs on tau provides an opportunity to better understand ...
Carolina Alquezar +2 more
doaj +1 more source