Results 41 to 50 of about 314,987 (288)
The Four Homeostasis Knights: In Balance upon Post-Translational Modifications [PDF]
, 2022 A cancer outcome is a multifactorial event that comes from both exogenous injuries and an endogenous predisposing background. The healthy state is guaranteed by the fine-tuning of genes controlling cell proliferation, differentiation, and development ...
Danilo Piobbico +15 more
core +1 more source
Scheme of EGR1 post-translational modifications. [PDF]
, 2013 Scheme of EGR1 post-translational modifications.
Daniela Tavian (342557) +5 more
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Post-translational modification of RAS proteins
Current Opinion in Structural Biology, 2021 Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS proteins integrate signals from a wide array of receptors and initiate downstream signaling through pathways that control cellular growth. RAS proteins are fundamentally binary molecular switches in which the off/on state is determined by the binding of GDP or GTP ...
Sharon L, Campbell, Mark R, Philips
openaire +2 more sources
Post-translational modifications of EZH2 in cancer
Cell & Bioscience, 2020 Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients.
Zhongwei Li +8 more
doaj +1 more source
Lysine-Directed Post-translational Modifications of Tau Protein in Alzheimer's Disease and Related Tauopathies [PDF]
, 2017 Tau is a microtubule-associated protein responsible mainly for stabilizing the neuronal microtubule network in the brain. Under normal conditions, tau is highly soluble and adopts an “unfolded” conformation.
Kontaxi, C +8 more
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Nature Communications, 2020 The mechanisms by which deubiquitinases modulate tumour progression are not fully understood. Here, the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a TRIM25 dependent manner, which in turn ...
Fangzhou Li +15 more
doaj +1 more source
Post-Translational Modification of MR Activity [PDF]
, 2019 The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that transduces the effects of aldosterone and glucocorticoids in a tissue- and cell type-specific ways.
Natalia Serrano-Morillas (7951631) +3 more
core +1 more source
Regulation of Streptomyces Chitinases by Two-Component Signal Transduction Systems and their Post Translational Modifications: A Review [PDF]
, 2018 This article reviews the developments related to Streptomyces chitinases regulation and their post translational modifications. Chitinases are enzymes which cleave chitin, a polymer of N-acetylglucosamine to its monomer.
Amrathlal Rabbind Singh
core +1 more source
Post-translational modifications in circadian rhythms [PDF]
Trends in Biochemical Sciences, 2009 The pace has quickened in circadian biology research. In particular, an abundance of results focused on post-translational modifications (PTMs) is sharpening our view of circadian molecular clockworks. PTMs affect nearly all aspects of clock biology; in some cases they are essential for clock function and in others, they provide layers of regulatory ...
Arun, Mehra +3 more
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Acute lymphoblastic leukaemia (ALL) is one of the most treatable forms of paediatric cancer; however, there is a substantial burden of treatment‐related toxicities (TRTs). In addition, the long‐term changes in children's health‐related quality of life (HRQoL) due to toxic treatments are not well understood.
Clare Ghows +19 more
wiley +1 more source