Results 41 to 50 of about 5,780,566 (282)

Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription [PDF]

, 2014
Post-translational modifications of proteins have emerged as a major mechanism for regulating gene expression. However, our understanding of how histone modifications directly affect chromatin function remains limited.
Holzner, M. (M), Eleni Kallis, Holzner, M., Michaelis, J., Richter, F. (F) M. (M), Ryan, D. (D) P. (P), Feldmann, A. (A), Daniel P Ryan, Owen-Hughes, Tom; id_orcid, Kacem, S., Tropberger, Philipp, Di Cerbo, V., Bannister, A., Kallis, E. (E), Michaelis, Jens, Feldmann, A., Richter, Florian, Martin, Daujat, S. (Sylvain), Robert Schneider, Richter, F., Tropberger, P., Hoerner, Leslie, Richter, Florian Martin, Mittler, G. (G), Emilie Montellier, Di Cerbo, V. (V), Feil, Robert, Bannister, A. (A) J. (J), Vincenzo Di Cerbo, Ryan, D., Kallis, Eleni, Ryan, D. P., Di Cerbo, Vincenzo, Owen-Hughes, T. (T), Leslie Hoerner, Jens Michaelis, Kallis, E., Khochbin, S. (S), Saadi Khochbin, Schneider, Robert, Holzner, Monika, Monika Holzner, Feil, R. (R), Ryan, Daniel, P., Feldmann, Angelika, Tom Owen-Hughes, Owen-Hughes, T., Bannister, A. J., Feil, R., Mohn, F., Hoerner, L., Fabio Mohn, Richter, F. M., Montellier, E. (E), Mittler, G., Schuebeler, D., Montellier, Emilie, Mohn, F. (F), Tropberger, P. (P), Angelika Feldmann, Owen-Hughes, Tom, Kacem, Salim, Mittler, Gerhard, Daujat, Sylvain, Montellier, E., Schneider, R., Dirk Schuebeler, Schuebeler, D. (D), Bannister, Andrew J., Hoerner, L. (L), Khochbin, S., Schneider, R. (Robert), Schuebeler, Dirk, Salim Kacem, Philipp Tropberger, Mohn, Fabio, Florian Martin Richter, Kacem, S. (S), Sylvain Daujat, Ryan, Daniel P., Andrew J Bannister, Khochbin, Saadi, Gerhard Mittler, Michaelis, J. (J), Robert Feil, Daujat, S.   +85 more
core   +1 more source

Post-translational protein modifications in schizophrenia [PDF]

npj Schizophrenia, 2020
AbstractResearch investigating the pathophysiology of schizophrenia has not yet precisely defined the molecular phenotype of this disorder. Many studies have investigated cellular dysfunction by examining expression levels of molecular targets in postmortem patient brain; however, inconsistencies between transcript and protein measures in schizophrenia
Toni M. Mueller, James H. Meador-Woodruff   +1 more
openaire   +2 more sources

Post-translational modifications of the polycystin proteins [PDF]

Cellular Signalling, 2020
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited cause of kidney failure and affects up to 12 million people worldwide. Germline mutations in two genes, PKD1 or PKD2, account for almost all patients with ADPKD.
Streets, A., Ong, A.
openaire   +3 more sources

Oxidatively Modified Proteins: Cause and Control of Diseases

Applied Sciences, 2020
Proteins succumb to numerous post-translational modifications (PTMs). These relate to enzymatic or non-enzymatic reactions taking place in either the intracellular or extracellular compartment.
Ramona Clemen, Sander Bekeschus
doaj   +1 more source

Regulation of the cardiac Na+ channel NaV1.5 by post-translational modifications. [PDF]

, 2015
The cardiac voltage-gated Na(+) channel, Na(V)1.5, is responsible for the upstroke of the action potential in cardiomyocytes and for efficient propagation of the electrical impulse in the myocardium.
Marionneau, Céline, Abriel, Hugues
core   +1 more source

Post-translational modifications on the retinoblastoma protein

Journal of Biomedical Science, 2022
The retinoblastoma protein (pRb) functions as a cell cycle regulator controlling G1 to S phase transition and plays critical roles in tumour suppression. It is frequently inactivated in various tumours.
Linbin Zhou, Danny Siu-Chun Ng, Jason C. Yam, Li Jia Chen, Clement C. Tham, Chi Pui Pang, Wai Kit Chu   +6 more
doaj   +1 more source

Potential protein post-translational modification in ERp57: A phenotype marker for male fertility

Journal of Human Reproductive Sciences, 2010
Background : In protein expression, post-translational modification is an important process. It is also an important process in human reproductive science. ERp57 is a molecule that is mentioned for post-translational modification. ERp57 is a component of
Viroj Wiwanitkit
doaj   +1 more source

Lysine-Directed Post-translational Modifications of Tau Protein in Alzheimer's Disease and Related Tauopathies [PDF]

, 2017
Tau is a microtubule-associated protein responsible mainly for stabilizing the neuronal microtubule network in the brain. Under normal conditions, tau is highly soluble and adopts an “unfolded” conformation.
Kontaxi, C, Pedro Piccardo, Kontaxi, Christiana, Piccardo, Pedro, Andrew C. Gill, Gill, Andrew C, Gill, AC, Christiana Kontaxi, Piccardo, P   +8 more
core   +1 more source

Post-translational modification of RAS proteins

Current Opinion in Structural Biology, 2021
Mutations of RAS genes drive cancer more frequently than any other oncogene. RAS proteins integrate signals from a wide array of receptors and initiate downstream signaling through pathways that control cellular growth. RAS proteins are fundamentally binary molecular switches in which the off/on state is determined by the binding of GDP or GTP ...
Sharon L, Campbell, Mark R, Philips
openaire   +2 more sources

OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity

Nature Communications, 2020
The mechanisms by which deubiquitinases modulate tumour progression are not fully understood. Here, the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a TRIM25 dependent manner, which in turn ...
Fangzhou Li, Qianqian Sun, Kun Liu, Ling Zhang, Ning Lin, Kaiqiang You, Mingwei Liu, Ning Kon, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Jun Qin, Wei Gu, Dawei Li, Wenhui Zhao   +15 more
doaj   +1 more source