Results 51 to 60 of about 469,548 (293)

Post-translational modifications of EZH2 in cancer

Cell & Bioscience, 2020
Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients.
Zhongwei Li, Minle Li, Diandian Wang, Pingfu Hou, Xintian Chen, Sufang Chu, Dafei Chai, Junnian Zheng, Jin Bai   +8 more
doaj   +1 more source

OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity

Nature Communications, 2020
The mechanisms by which deubiquitinases modulate tumour progression are not fully understood. Here, the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a TRIM25 dependent manner, which in turn ...
Fangzhou Li, Qianqian Sun, Kun Liu, Ling Zhang, Ning Lin, Kaiqiang You, Mingwei Liu, Ning Kon, Feng Tian, Zebin Mao, Tingting Li, Tanjun Tong, Jun Qin, Wei Gu, Dawei Li, Wenhui Zhao   +15 more
doaj   +1 more source

Efficient discovery of abundant post-translational modifications and spectral pairs using peptide mass and retention time differences [PDF]

, 2009
Background: Peptide identification via tandem mass spectrometry is the basic task of current proteomics research. Due to the complexity of mass spectra, the majority of mass spectra cannot be interpreted at present. The existence of unexpected or unknown
Yan Fu, Wei Jia, Zhuang Lu, Haipeng Wang, Zuofei Yuan, Hao Chi, You Li, Liyun Xiu, Wenping Wang, Chao Liu, Leheng Wang, Ruixiang Sun, Wen Gao, Xiaohong Qian, Si-Min He, R Aebersold, M Mann, ES Witze, JK Eng, DN Perkins, R Craig, Y Fu, J Colinge, LY Geer, V Dancik, A Frank, B Ma, JA Taylor, P Hernandez, M Mann, DL Tabb, S Tanner, A Keller, MM Savitski, N Bandeira, D Tsur, S Tanner, BC Searle, Y Han, PA Pevzner, F Potthast, N Bandeira, W Jia, KF Medzihradszky, LH Wang, JE Elias   +45 more
core   +1 more source

Post-translational protein modifications in schizophrenia [PDF]

npj Schizophrenia, 2020
AbstractResearch investigating the pathophysiology of schizophrenia has not yet precisely defined the molecular phenotype of this disorder. Many studies have investigated cellular dysfunction by examining expression levels of molecular targets in postmortem patient brain; however, inconsistencies between transcript and protein measures in schizophrenia
Toni M. Mueller, James H. Meador-Woodruff   +1 more
openaire   +2 more sources

Transcription factor LSF facilitiates lysine methylation of α-tubulin by microtubule-associated SET8 [PDF]

, 2019
Microtubules are critical for mitosis, cell motility, and protein and organelle transport, and are a validated target for anticancer drugs. However, tubulin regulation and recruitment in these cellular processes is less understood.
Chin, Hang Gyeong, Estève, Pierre Olivier, Hansen, Ulla, Lee, Jiyoung, Pradhan, Sriharsa, Ruse, Cristian, Schaus, Scott   +6 more
core   +1 more source

Post-translational modifications of transporters

Pharmacology & Therapeutics, 2018
Drug transporter proteins are critical to the distribution of a wide range of endogenous compounds and xenobiotics such as hormones, bile acids, peptides, lipids, sugars, and drugs. There are two classes of drug transporters- the solute carrier (SLC) transporters and ATP-binding cassette (ABC) transporters -which predominantly differ in the energy ...
Lindsay C, Czuba, Kathleen M, Hillgren, Peter W, Swaan   +2 more
openaire   +3 more sources

Control of protein stability by post-translational modifications

Nature Communications, 2023
Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee, Henrik M. Hammarén, Mikhail M. Savitski, Sung Hee Baek   +3 more
doaj   +1 more source

Citrullination – small change with a great consequence [PDF]

, 2013
Citrullination is one of the possible post-translational modifications of proteins. It is based on a conversion of L-arginine residue (L-Arg) to L-citrulline residue (L-Cit). The reaction is catalyzed by peptidylarginine deiminases (PAD). The change of L-
Gogól Mariusz
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Regulation of Lignin Biosynthesis by Post-translational Protein Modifications

Frontiers in Plant Science, 2020
Post-translational modification of proteins exerts essential roles in many biological processes in plants. The function of these chemical modifications has been extensively characterized in many physiological processes, but how these modifications ...
Daniel B. Sulis, Jack P. Wang
doaj   +1 more source