Tubulin Post-Translational Modifications and Microtubule Dynamics
, 2017 Microtubules are hollow tube-like polymeric structures composed of α,β-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell ...
Ewa Joachimiak +2 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Post-translational modifications involved in the biosynthesis of thiopeptide antibiotics
, 2017 Thiopeptide antibiotics are generated from ribosomally synthesized peptides via a cascade of post-translational modifications (PTMs).
Qingfei Zheng, Hui Fang, Wen Liu
core +1 more source
The Potential Roles of Post-Translational Modifications of PPARγ in Treating Diabetes
Biomolecules, 2022 The number of patients with type 2 diabetes mellitus (T2DM), which is mainly characterized by insulin resistance and insulin secretion deficiency, has been soaring in recent years.
Xiaohui Ji +6 more
doaj +1 more source
Post-translational modifications of PML: consequence and implications [PDF]
, 2013 The tumor suppressor promyelocytic leukemia protein (PML) predominantly resides in a structurally distinct sub-nuclear domain called PML nuclear bodies (NBs).
Xiwen eCheng +3 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
AMS 3.0: prediction of post-translational modifications
BMC Bioinformatics, 2010 Background We present here the recent update of AMS algorithm for identification of post-translational modification (PTM) sites in proteins based only on sequence information, using artificial neural network (ANN) method.
Plewczynski Dariusz, Basu Subhadip
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Hsp60 Post-translational Modifications: Functional and Pathological Consequences
Frontiers in Molecular Biosciences, 2020 Hsp60 is a chaperone belonging to the Chaperonins of Group I and typically functions inside mitochondria in which, together with the co-chaperonin Hsp10, maintains protein homeostasis.
Celeste Caruso Bavisotto +14 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Novel post-translational modifications in cancer
OncologieThe increasing incidence of cancer highlights the urgency for a deeper understanding of its complex pathogenesis. Recent research has identified novel post-translational modifications (PTMs) as key contributors to cancer. This review examines the role of
Li Dongling +7 more
doaj +1 more source