Results 11 to 20 of about 5,990,239 (290)
Post-Translational Modifications and Diabetes
BiomoleculesDiabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D).
Chiranjeev Sharma +4 more
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Post-translational modifications of exosomal proteins
Frontiers in Immunology, 2014 Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection.
Olga eMoreno-Gonzalo +2 more
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Post-translational modifications and their implications in cancer [PDF]
Frontiers in Oncology, 2023 Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Nishant Jain, Hashnu Dutta
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Post-translational modifications of EZH2 in cancer [PDF]
Cell & Bioscience, 2020 Enhancer of zeste homolog 2 (EZH2), as a main component of Polycomb Repressive Complex 2, catalyzes histone H3K27me3 to silence its target gene expression. EZH2 upregulation results in cancer development and poor prognosis of cancer patients.
Zhongwei Li +8 more
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Control of protein stability by post-translational modifications
Nature Communications, 2023 Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee +3 more
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Post-translational modifications in prion diseases
Frontiers in Molecular NeuroscienceMore than 650 reversible and irreversible post-translational modifications (PTMs) of proteins have been listed so far. Canonical PTMs of proteins consist of the covalent addition of functional or chemical groups on target backbone amino-acids or the ...
Chloé Bizingre +12 more
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Editorial: Bacterial Post-translational Modifications
Frontiers in Microbiology, 2022 International ...
Valerie J. Carabetta +2 more
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Spin labelling via metabolic glycoengineering for studying post-translational protein modification by electron paramagnetic resonance spectroscopy [PDF]
, 2023 Post-translational modifications are involved in many cellular processes. The addition of O-linked β-N-acetylglucosamine (O-GlcNAc) is a ubiquitous post-translational modification essential for regulatory processes in mammalian cells.
Malte, Drescher +2 more
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The Role of Post-Translational Modifications in Necroptosis
BiomoleculesNecroptosis, a distinct form of regulated necrosis implicated in various human pathologies, is orchestrated through sophisticated signaling pathways. During this process, cells undergoing necroptosis exhibit characteristic necrotic morphology and provoke
Hao Xiao +7 more
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Post-translation modifications [PDF]
Current Opinion in Chemical Biology, 2009 The development of proteomics has been one of the great achievements in analytical chemical biology in the past ten years. The determination of the total protein constituents in biological samples has allowed new and unprecedented insights into cellular processes and diseases.
Carlito B, Lebrilla, Lara K, Mahal
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