Results 11 to 20 of about 267,857 (250)
Regulation of the microprocessor by post-translational modifications [PDF]
Frontiers in Cell and Developmental BiologyThe Microprocessor is an essential protein complex that is responsible for the first processing step in the biogenesis of canonical microRNAs. The core of this complex is composed of two proteins, the ribonuclease III enzyme DROSHA and its double ...
Ka Weng Leong +3 more
doaj +4 more sources
Post-translational modifications and their implications in cancer
Frontiers in Oncology, 2023 Post-translational modifications (PTMs) are crucial regulatory mechanisms that alter the properties of a protein by covalently attaching a modified chemical group to some of its amino acid residues. PTMs modulate essential physiological processes such as
Hashnu Dutta +3 more
doaj +5 more sources
Post‐Translational Modifications in Animal Circadian Clocks [PDF]
Advanced ScienceThe circadian clock is a fundamental biological system that synchronizes behavioral and physiological processes such as metabolism and immunity with the 24 h day‐night cycle.
Xianhui Liu, Yong Zhang
doaj +2 more sources
Post-Translational Modifications and Diabetes
BiomoleculesDiabetes and its associated complications have increasingly become major challenges for global healthcare. The current therapeutic strategies involve insulin replacement therapy for type 1 diabetes (T1D) and small-molecule drugs for type 2 diabetes (T2D).
Chiranjeev Sharma +4 more
doaj +3 more sources
Post-Translational Modifications of Extracellular Proteasome [PDF]
Molecules, 2020 The ubiquitin-proteasome system (UPS) is one of the major protein degradation pathways in eukaryotic cells. Abnormal functioning of this system has been observed in cancer and neurological diseases.
Anna S. Tsimokha +4 more
doaj +3 more sources
Post-translational modifications of exosomal proteins
Frontiers in Immunology, 2014 Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection.
Olga eMoreno-Gonzalo +2 more
doaj +5 more sources
Post‐Translational Modifications in Cilia and Ciliopathies [PDF]
Advanced ScienceCilia are microtubule‐based organelles that extend from the surface of most vertebrate cells, and they play important roles in diverse cellular processes during embryonic development and tissue homeostasis.
Jie Ran, Jun Zhou
doaj +2 more sources
Histone post-translational modifications of Leishmania braziliensis [PDF]
Scientific DataHistone post-translational modifications (hPTMs) constitute an epigenetic mechanism that plays a fundamental role in the regulation of gene expression in eukaryotic cells. In trypanosomatid parasites, such as Trypanosoma brucei, T.
Rafael Fogaça de Almeida +3 more
doaj +2 more sources
Control of protein stability by post-translational modifications
Nature Communications, 2023 Here the authors summarize current knowledge of the regulation of protein stability by various post-translational modifications (PTMs) including methylation and phosphorylation.
Ji Min Lee +3 more
doaj +2 more sources
Post-translational modifications of protein and lung cancer [PDF]
Frontiers in OncologyPost-translational modifications (PTMs) represent a pivotal regulatory mechanism in cellular processes, wherein the addition or removal of specific functional groups to amino acid residues dynamically modulates protein activity, subcellular localization,
Ying Zhao +10 more
doaj +2 more sources