SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors. [PDF]
PLoS ONE, 2010 BACKGROUND:Hedgehog (Hh) signaling, a vital signaling pathway for the development and homeostasis of vertebrate tissues, is mediated by members of the Gli family of zinc finger transcription factors. Hh signaling increases the transcriptional activity of
Barny Cox, James Briscoe, Fausto Ulloa
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Processing and targeting of proteins derived from polyprotein with 2A and LP4/2A as peptide linkers in a maize expression system. [PDF]
PLoS ONE, 2017 In the transformation of multiple genes, gene fusion is an attractive alternative to other methods, including sexual crossing, re-transformation, and co-transformation, among others.
He Sun +4 more
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Scientific Reports, 2021 Post-translational processing leads to conformational changes in protein structure that modulate molecular functions and change the signature of metabolic transformations and immune responses.
Dmitry Tikhonov +11 more
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Post-translational processing of chicken bone phosphoproteins. Identification of bone (phospho)protein kinase [PDF]
Biochemical Journal, 1990 We have detected a protein kinase which phosphorylates bone phosphoproteins (BPPs) in the detergent extract of the membranous fractions in the periosteal bone strips of 12-day-embryonic-chick tibia. This enzyme, tentatively named BPP kinase, has a catalytic subunit of Mr approximately 39,000, utilizes GTP as well as ATP as a phospho-group donor, is ...
Y, Mikuni-Takagaki, M J, Glimcher
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BMC Bioinformatics, 2022 Motivation Protein-protein interactions (PPIs) are critical to normal cellular function and are related to many disease pathways. A range of protein functions are mediated and regulated by protein interactions through post-translational modifications ...
Aparna Elangovan +4 more
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To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
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Cytoplasmic interaction with CYCLE promotes the post‐translational processing of the circadian CLOCK protein [PDF]
FEBS Letters, 2009 CLK (uniprotkb:O61735) binds (MI:0407) to Cyc (uniprotkb:O61734) by pull down (MI:0096)
Maurer, Christian +2 more
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An update on transcriptional and post-translational regulation of brain voltage-gated sodium channels [PDF]
, 2015 Voltage-gated sodium channels are essential proteins in brain physiology, as they generate the sodium currents that initiate neuronal action potentials.
Beltran-Alvarez, Pedro +1 more
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Circadian rhythms and post-transcriptional regulation in higher plants [PDF]
, 2015 The circadian clock of plants allows them to cope with daily changes in their environment. This is accomplished by the rhythmic regulation of gene expression, in a process that involves many regulatory steps.
Romanowski, Andrés +1 more
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Journal of Biological Chemistry, 1992 Human protein C (HPC) undergoes several post-translational modifications, including gamma-carboxylation, N-linked glycosylation, and internal proteolytic processing. We have utilized a recombinant human kidney cell line (293) secreting correctly modified
D. Mcclure, J. Walls, B. Grinnell
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