Results 31 to 40 of about 233,151 (265)

Post-translational processing of Schizosaccharomyces pombe YPT proteins.

Journal of Biological Chemistry, 1992
ras proteins are post-translationally processed at their carboxyl-terminal CAAX motif by a triplet of modifications: prenylation of C with farnesyl, proteolytic trimming of AAX, and carboxyl-methylation. These modifications co-operate with palmitoylation of nearby sites or a polybasic region to target plasma membrane localization.
C M, Newman, T, Giannakouros, J F, Hancock, E H, Fawell, J, Armstrong, A I, Magee   +5 more
openaire   +2 more sources

Experimental annotation of post-translational features and translated coding regions in the pathogen Salmonella Typhimurium

BMC Genomics, 2011
Background Complete and accurate genome annotation is crucial for comprehensive and systematic studies of biological systems. However, determining protein-coding genes for most new genomes is almost completely performed by inference using computational ...
Smith Richard D, Venepally Pratap, Monroe Matthew E, Burnet Meagan C, Martin Jessica L, Payne Samuel H, Yoon Hyunjin, Jones Marcus, Porwollik Steffen, Purvine Samuel O, Tolić Nikola, Ansong Charles, Peterson Scott N, Heffron Fred, McClelland Michael, Adkins Joshua N   +15 more
doaj   +1 more source

Acetylome Analysis Identifies SIRT1 Targets in mRNA-Processing and Chromatin-Remodeling in Mouse Liver. [PDF]

PLoS ONE, 2015
Lysine acetylation is a post-translational modification found on numerous proteins, a strategy used in cell signaling to change protein activity in response to internal or external cues.
Sun-Yee Kim, Choon Kiat Sim, Hui Tang, Weiping Han, Kangling Zhang, Feng Xu   +5 more
doaj   +1 more source

Characterization of the Proprotein Convertase-Mediated Processing of Peroxidasin and Peroxidasin-like Protein

Antioxidants, 2021
Peroxidasin (PXDN) and peroxidasin-like protein (PXDNL) are members of the peroxidase-cyclooxygenase superfamily. PXDN functions in basement membrane synthesis by forming collagen IV crosslinks, while the function of PXDNL remains practically unknown. In
Hajnal A. Kovács, Enikő Lázár, György Várady, Gábor Sirokmány, Miklós Geiszt   +4 more
doaj   +1 more source

Dissecting ribosomal particles throughout the kingdoms of life using advanced hybrid mass spectrometry methods

Nature Communications, 2018
The authors demonstrate a 3-tier mass spectrometry approach, including bottom-up and top-down proteomics, as well as native mass spectrometry to provide a detailed description of proteoforms, protein processing and post-translational modifications ...
Michiel van de Waterbeemd, Sem Tamara, Kyle L. Fort, Eugen Damoc, Vojtech Franc, Philipp Bieri, Martin Itten, Alexander Makarov, Nenad Ban, Albert J. R. Heck   +9 more
doaj   +1 more source

Genomic Variability and Post-translational Protein Processing Enhance the Immune Evasion of Mycoplasma hyopneumoniae and Its Interaction With the Porcine Immune System

Frontiers in Immunology, 2020
Mycoplasma hyopneumoniae (M. hyopneumoniae, Mhp) is a geographically widespread and economically devastating pathogen that colonizes ciliated epithelium; the infection of Mhp can damnify the mucociliary functions as well as leading to Mycoplasma ...
Gaojian Li, Enoch Obeng, Jinqi Shu, Jianhong Shu, Jianhong Shu, Jian Chen, Yuehong Wu, Yulong He   +7 more
doaj   +1 more source

Post-translational processing of chicken bone phosphoproteins. Identification of bone (phospho)protein kinase [PDF]

Biochemical Journal, 1990
We have detected a protein kinase which phosphorylates bone phosphoproteins (BPPs) in the detergent extract of the membranous fractions in the periosteal bone strips of 12-day-embryonic-chick tibia. This enzyme, tentatively named BPP kinase, has a catalytic subunit of Mr approximately 39,000, utilizes GTP as well as ATP as a phospho-group donor, is ...
Y, Mikuni-Takagaki, M J, Glimcher
openaire   +2 more sources

Diurnal Differences in Human Muscle Isometric Force In Vivo Are Associated with Differential Phosphorylation of Sarcomeric M-Band Proteins

Proteomes, 2020
We investigated whether diurnal differences in muscle force output are associated with the post-translational state of muscle proteins. Ten physically active men (mean ± SD; age 26.7 ± 3.7 y) performed experimental sessions in the morning (08:00 h) and ...
Zulezwan Ab Malik, Kelly A. Bowden Davies, Elliott C. R. Hall, Jennifer Barrett, Samuel A. Pullinger, Robert M. Erskine, Sam O. Shepherd, Zafar Iqbal, Ben J. Edwards, Jatin G. Burniston   +9 more
doaj   +1 more source

Automated assembly of molecular mechanisms at scale from text mining and curated databases

Molecular Systems Biology, 2023
The analysis of omic data depends on machine‐readable information about protein interactions, modifications, and activities as found in protein interaction networks, databases of post‐translational modifications, and curated models of gene and protein ...
John A Bachman, Benjamin M Gyori, Peter K Sorger   +2 more
doaj   +1 more source

Biosynthesis of intestinal microvillar proteins. The effect of swainsonine on post-translational processing of aminopeptidase N [PDF]

Biochemical Journal, 1983
The post-translational processing of pig small-intestinal aminopeptidase N (EC 3.4.11.2) was studied in organ-cultured mucosal explants. Exposure of the explants to swainsonine, an inhibitor of Golgi mannosidase II, resulted in the formation of a Mr-160000 polypeptide, still sensitive to endo-beta-N-acetylglucosaminidase H.
Danielsen, E M, Cowell, G M, Norén, Ove, Sjöström, H, Dorling, P R   +4 more
openaire   +2 more sources