FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
PubMed-Scale Event Extraction for Post-Translational Modifications, Epigenetics and Protein Structural Relations [PDF]
, 2012 Recent efforts in biomolecular event extraction have mainly focused on core event types involving genes and proteins, such as gene expression, protein-protein interactions, and protein catabolism.
Björne, Jari +15 more
core
Codon usage suggests that translational selection has a major impact on protein expression in trypanosomatids. [PDF]
, 2008 BACKGROUND: Different proteins are required in widely different quantities to build a living cell. In most organisms, transcription control makes a major contribution to differential expression.
Horn, David +2 more
core +1 more source
Glycosylation and S-palmitoylation regulate SARS-CoV-2 spike protein intracellular trafficking
iScience, 2022 Summary: Post-translational modifications (PTMs), such as glycosylation and palmitoylation, are critical to protein folding, stability, intracellular trafficking, and function.
Chih-Feng Tien +13 more
doaj +1 more source
Novel biochemistry: post-translational protein splicing and other lessons from the school of antigen processing [PDF]
Journal of Molecular Medicine, 2005 In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor cells by T cells has been vigorously pursued. Molecular identification of tumor-associated antigens not only provided the means to activate or monitor anti-tumor immunity, but also gave insights into new and unexpected biochemical processes that are ...
Hanada, Ken-Ichi, Yang, James C.
openaire +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Post-Translational Deimination of Immunological and Metabolic Protein Markers in Plasma and Extracellular Vesicles of Naked Mole-Rat (Heterocephalus glaber) [PDF]
, 2019 Naked mole-rats are long-lived animals which show unusual resistance to hypoxia, cancer and ageing. Protein deimination is an irreversible post-translational modification caused by the peptidylarginine deiminase (PADs) family of enzymes, which convert ...
Pamenter, Matthew E. +12 more
core +1 more source
How can platelet proteomics best be used to interrogate disease?
Platelets, 2023 Various modifications of proteins and the resulting proteoforms of a protein can associate with many diseases and are also significantly involved in the rapid regulation of hemostasis and thrombosis.
Maria Zellner
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Complement component C4-like protein in Atlantic cod (Gadus morhua L.) - Detection in ontogeny and identification of post-translational deimination in serum and extracellular vesicles [PDF]
, 2019 The complement system is a critical part of teleost immune defences, with complement component C4 forming part of the classical and lectin pathways.
Lange, S. +7 more
core +1 more source