Results 51 to 60 of about 233,151 (265)

Comprehensive analysis of human protein N-termini enables assessment of various protein forms

Scientific Reports, 2017
Various forms of protein (proteoforms) are generated by genetic variations, alternative splicing, alternative translation initiation, co- or post-translational modification and proteolysis.
Jeonghun Yeom, Shinyeong Ju, YunJin Choi, Eunok Paek, Cheolju Lee   +4 more
doaj   +1 more source

Cellular electron microscopy imaging reveals the localization of the Hfq protein close to the bacterial membrane.

PLoS ONE, 2009
BackgroundHfq is a bacterial protein involved in several aspects of nucleic acid transactions, but one of its best-characterized functions is to affect the post-transcriptional regulation of mRNA by virtue of its interactions with stress-related small ...
Elia Diestra, Bastien Cayrol, Véronique Arluison, Cristina Risco   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Cellular Processing of the ABCG2 Transporter—Potential Effects on Gout and Drug Metabolism

Cells, 2019
The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells.
Orsolya Mózner, Zsuzsa Bartos, Boglárka Zámbó, László Homolya, Tamás Hegedűs, Balázs Sarkadi   +5 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Regulation of plant immune receptor accumulation through translational repression by a glycine-tyrosine-phenylalanine (GYF) domain protein

eLife, 2017
Plant immunity is tightly regulated to ensure proper defense against surrounding microbial pathogens without triggering autoimmunity, which negatively impacts plant growth and development.
Zhongshou Wu, Shuai Huang, Xiaobo Zhang, Di Wu, Shitou Xia, Xin Li   +5 more
doaj   +1 more source

RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. [PDF]

PLoS Genetics, 2014
Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels. However, how the cell integrates RNA-processing programs with post-translational protein quality control systems is unknown ...
Tao Zhang, Gerard Baldie, Goran Periz, Jiou Wang   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

PTG-PLM: Predicting Post-Translational Glycosylation and Glycation Sites Using Protein Language Models and Deep Learning

Axioms, 2022
Post-translational glycosylation and glycation are common types of protein post-translational modifications (PTMs) in which glycan binds to protein enzymatically or nonenzymatically, respectively.
Alhasan Alkuhlani, Walaa Gad, Mohamed Roushdy, Michael Gr. Voskoglou, Abdel-badeeh M. Salem   +4 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source