Results 51 to 60 of about 244,545 (310)
Mass spectrometry quantification of clusterin in the human brain
Molecular Neurodegeneration, 2012 Background The multifunctional glycoprotein clusterin has been associated with late-onset Alzheimer’s disease (AD). Further investigation to define the role of clusterin in AD phenotypes would be aided by the development of techniques to quantify level ...
Chen Junjun +2 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Protein-RNA interactions: a structural analysis [PDF]
, 2001 A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT +9 more
core
Proteolytic Post-Translational Processing of Adhesins in a Pathogenic Bacterium [PDF]
, 2017 UMR BFP - Equipe MollicuteMollicutes, including mycoplasmas and spiroplasmas, have been considered as good representatives of the « minimal cell » concept: these wall-less bacteria are small in size and possess a minimal genome and restricted metabolic ...
Blanchard, Alain +19 more
core +1 more source
Rescue of Heart Failure by Mitochondrial Recovery [PDF]
International Neurourology Journal, 2016 Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments can only prevent further ...
Jubert Marquez +3 more
doaj +1 more source
Novel biochemistry: post-translational protein splicing and other lessons from the school of antigen processing [PDF]
Journal of Molecular Medicine, 2005 In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor cells by T cells has been vigorously pursued. Molecular identification of tumor-associated antigens not only provided the means to activate or monitor anti-tumor immunity, but also gave insights into new and unexpected biochemical processes that are ...
Hanada, Ken-Ichi, Yang, James C.
openaire +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Label-free single-molecule nanopore analysis of protein post-translational modifications [PDF]
Despite significant advancements and refinements in single-molecule nanopore technology for DNA and RNA sequencing, its applicability to protein analysis remains limited.
Martin-Baniandres, Pablo
core +2 more sources
Protein Disordered Region Prediction by SVM with Post-Processing [PDF]
, 2012 In proteomics, a proteinpsilas function is always strongly related to its structure. But, while some parts of a protein have a fixed definite structure, such as alpha-helix, beta-sheet, or coil, other parts are not associated with well-defined ...
Hsieh, Cheng-wei; Hsu, Hui-huang; Lu, Ming-da
core +1 more source
eLife, 2023 Dystroglycan (DG) requires extensive post-translational processing and O-glycosylation to function as a receptor for extracellular matrix (ECM) proteins containing laminin-G (LG) domains.
Hidehiko Okuma +11 more
doaj +1 more source