Summary of the putative post translational modifications in 50L protein.
, 2013 Summary of the putative post translational modifications in 50L protein.
Qi-Ya Zhang (311840) +2 more
core +1 more source
Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2017 Alzheimer’s disease (AD), the most common neurodegenerative disorder, is the leading cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology, mainly consists of amyloid β (Aβ) protein.
Xin Wang +12 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Effect of enzymatic deimination on the conformation of recombinant prion protein [PDF]
, 2009 Deimination is the post-translational conversion of arginine residues to citrulline. It has been implicated as a causative factor in autoimmune diseases such as multiple sclerosis and rheumatoid arthritis and more recently, as a marker of ...
Oxley, David +6 more
core
Conservation profile of nsSNPs in FOXP2 protein and their post translational modification.
, 2022 Conservation profile of nsSNPs in FOXP2 protein and their post translational modification.
Fahmida Sultana Rima (13222422) +3 more
core +1 more source
PLoS ONE, 2009 BackgroundHfq is a bacterial protein involved in several aspects of nucleic acid transactions, but one of its best-characterized functions is to affect the post-transcriptional regulation of mRNA by virtue of its interactions with stress-related small ...
Elia Diestra +3 more
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Cellular Processing of the ABCG2 Transporter—Potential Effects on Gout and Drug Metabolism
Cells, 2019 The human ABCG2 is an important plasma membrane multidrug transporter, involved in uric acid secretion, modulation of absorption of drugs, and in drug resistance of cancer cells.
Orsolya Mózner +5 more
doaj +1 more source
RNA-processing protein TDP-43 regulates FOXO-dependent protein quality control in stress response. [PDF]
PLoS Genetics, 2014 Protein homeostasis is critical for cell survival and functions during stress and is regulated at both RNA and protein levels. However, how the cell integrates RNA-processing programs with post-translational protein quality control systems is unknown ...
Tao Zhang +3 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source