Results 91 to 100 of about 11,466,555 (302)

Ubiquitin Regulation: The Histone Modifying Enzyme′s Story

Cells, 2018
Histone post-translational modifications influence many fundamental cellular events by regulating chromatin structure and gene transcriptional activity.
Jianlin Wang, Zhaoping Qiu, Yadi Wu
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

The Effects of Post-Translational Modifications on Repulsive Guidance Molecules [PDF]

, 2023
Post-translational modifications (PTMs) play an important role in diversifying the role of a single protein. Here, we show how post-translational modification of repulsive guidance molecules (RGMs) can impact their function.
Mun, Eric
core   +1 more source

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ

iScience, 2019
Summary: CCAAT enhancer-binding protein beta (C/EBPβ) is a pioneer transcription factor that specifies cell differentiation. C/EBPβ is intrinsically unstructured, a molecular feature common to many proteins involved in signal processing and epigenetics ...
Gunnar Dittmar, Daniel Perez Hernandez, Elisabeth Kowenz-Leutz, Marieluise Kirchner, Günther Kahlert, Radoslaw Wesolowski, Katharina Baum, Maria Knoblich, Maria Hofstätter, Arnaud Muller, Jana Wolf, Ulf Reimer, Achim Leutz   +12 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Post-translational Protein Deimination in Cod (Gadus morhua L.) Ontogeny: Novel Roles in Tissue Remodelling and Mucosal Immune Defences? [PDF]

, 2018
Peptidylarginine deiminases (PADs) are calcium dependent enzymes with physiological and pathophysiological roles conserved throughout phylogeny. PADs promote post-translational deimination of protein arginine to citrulline, altering the structure and ...
Birkir Thor Bragason, Alister W. Dodds, Dodds, A.W., Sigrun Lange, Bragason, B., Lange, S, Mariya Hristova, Hristova, Mariya, Bragason, Birkir, Dodds, Alister W., Anthony P. Nicholas, Magnadóttir, B, Lange, Sigrun, Magnadottir, Bergljot, Hayes, Polly, Dodds, AW, Hristova, M., Hayes, P, Bragason, BT, Nicholas, AP, Bergljót Magnadóttir, Gudmundsdottir, S., Lange, S., Nicholas, A.P., Nicholas, Anthony P., Polly Hayes, Hristova, M, Guðmundsdóttir, S, Guðmundsdóttir, Sigríður, Magnadóttir, B., Hayes, P.M., Sigríður Guðmundsdóttir   +31 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Focal cerebral ischemia in rats alters APP processing and expression of Aβ peptide degrading enzymes in the thalamus

Neurobiology of Disease, 2009
We have previously demonstrated aggregation of amyloid precursor protein (APP) and β-amyloid (Aβ) to dense plaque-like deposits in the thalamus of rats subjected to transient middle cerebral artery occlusion (MCAO).
Mikko Hiltunen, Petra Mäkinen, Sirpa Peräniemi, Juhani Sivenius, Thomas van Groen, Hilkka Soininen, Jukka Jolkkonen   +6 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Potential protein post-translational modifications and find potential single amino acid substitutions in hepatitis B large envelope protein [PDF]

, 2008
Post-translational modifications of proteins control many biological processes. This is also important process in virus including hepatitis B. However, there is no in-depth study on the whole hepatitis B virus large envelope protein.
Wiwanitkit,V.
core   +1 more source