Results 91 to 100 of about 136,607 (295)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Diversity and Divergence of Dinoflagellate Histone Proteins

G3: Genes, Genomes, Genetics, 2016
Histone proteins and the nucleosomal organization of chromatin are near-universal eukaroytic features, with the exception of dinoflagellates. Previous studies have suggested that histones do not play a major role in the packaging of dinoflagellate ...
Georgi K. Marinov, Michael Lynch
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Parasite histones are toxic to brain endothelium and link blood barrier breakdown and thrombosis in cerebral malaria. [PDF]

, 2020
Microvascular thrombosis and blood-brain barrier (BBB) breakdown are key components of cerebral malaria (CM) pathogenesis in African children and are implicated in fatal brain swelling.
Toh, Cheng Hock, Taylor, Terrie E., Molyneux, Malcolm, Sam Kampondeni (114917), Moxon, Christopher A, Abrams, Simon T, Craig, Alister G, Abrams, Simon T., Taylor, Terrie E, James O'Donnell (7895615), Ko, Joo Yeon, García-Cardeña, Guillermo, Potchen, Michael, Kampondeni, Sam, Karl B Seydel (10940154), Toh, Cheng-Hock, Cheng-Hock Toh (739342), O'Donnell, James S., Niamh O'Regan (698186), Moxon, Christopher A., Toh, Cheng, McGuinness, Dagmara, Lane, Steven, Craig, Alister, O’Donnell, James S, Toh, Julien M.H., Seydel, Karl B., Yasir Alhamdi (611011), Wang, Guozheng, Storm, Janet, Simon T Abrams (10940165), Alhamdi, Yasir, O'Donnell, James S, Murphy, George, Alhamadi, Yasir, Alister G Craig (10940163), Julien M H Toh (10940148), Guozheng Wang (611014), Janet Storm (37473), George Murphy (214866), O’Regan, Niamh, Dagmara McGuinness (430856), Seydel, Karl B, Michael Potchen (3500972), Malcolm Molyneux (1711), O'Regan, Niamh, Steven Lane (347900), Joo Yeon Ko (10940151), Toh, Julien MH, Guillermo García-Cardenã (10940162), Terrie E Taylor (10940153), García- Cardeña, Guillermo, Christopher A Moxon (10940147)   +52 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Core histones and linker histones are imported into the nucleus by different pathways

, 2001
Histories are the major structural proteins in eukaryotic chromosomes. This group of small very basic proteins consists of the H1 linker histones and the core histones H2A, H2B, H3 and H4.
Baake, M., Bauerle, M., Doenecke, D., Albig, W.   +3 more
core   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Folding trajectories of eukaryotic histones and archaeal histones.

Folding trajectories of histones show the folding of the native and inverted non-native conformation of eukaryotic histones H2A/H2B and archaeal histones HmfA/HmfA. (MP4)
Christina M. Camara (17743432), Yamini Dalal (33140), Haiqing Zhao (2937306), Dulith Abeykoon (4916302), Garegin A. Papoian (691984), Hao Wu (65943), David Fushman (239364), Alex Guseman (17743429)   +7 more
core   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source