Results 91 to 100 of about 183,055 (305)

Histones and histone modifications in protozoan parasites

Cellular Microbiology, 2006
Protozoan parasites are early branching eukaryotes causing significant morbidity and mortality in humans and livestock. Single-celled parasites have evolved complex life cycles, which may involve multiple host organisms, and strategies to evade host immune responses.
William J, Sullivan, Arunasalam, Naguleswaran, Sergio O, Angel   +2 more
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Artificial intelligence meets epigenetics: a new frontier in precision oncology

Epigenetics Reports
Epigenetics involves heritable and stable changes in gene expression that occur without altering the DNA sequence, primarily through chemical modifications to DNA and alterations in chromatin structure.
Ruby Srivastava
doaj   +1 more source

Diversity and Divergence of Dinoflagellate Histone Proteins

G3: Genes, Genomes, Genetics, 2016
Histone proteins and the nucleosomal organization of chromatin are near-universal eukaroytic features, with the exception of dinoflagellates. Previous studies have suggested that histones do not play a major role in the packaging of dinoflagellate ...
Georgi K. Marinov, Michael Lynch
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A length-dynamic Tonks gas theory of histone isotherms

, 2002
We find exact solutions to a new one-dimensional (1D) interacting particle theory and apply the results to the adsorption and wrapping of polymers (such as DNA) around protein particles (such as histones).
Marko J. F., Piasecki J., Poland D., Sinden R. R., Thompson C., Tom Chou, Vilfan A., Vilfan A., Widom J.   +8 more
core   +1 more source

The enzymes LSD1 and Set1A cooperate with the viral protein HBx to establish an active hepatitis B viral chromatin state [PDF]

, 2016
Indexación: Web of ScienceWith about 350 million people chronically infected around the world hepatitis B is a major health problem. Template for progeny HBV synthesis is the viral genome, organized as a minichromosome (cccDNA) inside the hepatocyte ...
Alarcon, V, Alvarez, F, De Ferrari, GV, Flores, Y, Hernandez, S, Kann, M, Loyola, A, Rubio, L, Varas-Godoy, M, Villanueva, RA   +9 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease.
A. D. McAinsh, A. Desai, A. F. Straight, A. Losada, A. Musacchio, B. A. Sullivan, B. E. Black, B. G. Mellone, B. R. Brinkley, BA Sullivan, C. E. Sunkel, C. E. Walczak, CJ Lawrence, D. Foltz, D. M. Glover, D. W. Cleveland, D. W. Gerlich, DK Palmer, DR Foltz, E. D. Salmon, ES Alnemri, G. J. Gorbsky, G. J. P. L. Kops, G. Karpen, G. P. Copenhaver, H. F. Willard, H. Maiato, H. Masumoto, I. M. Cheeseman, J Ohzeki, J. G. DeLuca, J. R. Swedlow, K. Bloom, K. C. Scott, K. F. Sullivan, K. H. A. Choo, K. Luger, K. Oegema, K. Yoda, KF Sullivan, L. E. T. Jansen, L. Wordeman, M. A. Lampson, M. Fitzgerald-Hayes, M. Yanagida, MD Blower, P. E. Warburton, P. Heun, P. Meraldi, P. S. Maddox, P. T. Stukenberg, PB Talbert, R. C. Allshire, R. Gassmann, R. J. O’Neill, R. L. Margolis, S Ando, S Henikoff, S Stoler, S. C. Harrison, S. Diekmann, S. Erhardt, S. M. Lens, S. Westermann, SA Ribeiro, T Hori, T Nishino, T. Fukagawa, T. Hirota, T. J. Yen, W. Brown, W. C. Earnshaw, WC Earnshaw   +72 more
core   +9 more sources