Results 1 to 10 of about 714,644 (288)

DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation

Cell Reports, 2021
Summary: Histone lysine methylation functions at the interface of the extracellular environment and intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known ...
Tanjing Song, Qingli Zou, Yingying Yan, Suli Lv, Neng Li, Xuefeng Zhao, Xianyun Ma, Haigang Liu, Borui Tang, Lidong Sun   +9 more
doaj   +1 more source

Dek219 encodes the DICER-LIKE1 protein that affects chromatin accessibility and kernel development in maize

Journal of Integrative Agriculture, 2023
Chromatin accessibility plays a vital role in gene transcriptional regulation. However, the regulatory mechanism of chromatin accessibility, as well as its role in regulating crucial gene expression and kernel development in maize (Zea mays) are poorly ...
Si-di XIE, Ran TIAN, Jun-jie ZHANG, Han-mei LIU, Yang-ping LI, Yu-feng HU, Guo-wu YU, Yu-bi HUANG, Ying-hong LIU   +8 more
doaj   +1 more source

Impaired Regulation of Histone Methylation and Acetylation Underlies Specific Neurodevelopmental Disorders

Frontiers in Genetics, 2021
Epigenetic processes are critical for governing the complex spatiotemporal patterns of gene expression in neurodevelopment. One such mechanism is the dynamic network of post-translational histone modifications that facilitate recruitment of transcription
Merrick S. Fallah, Merrick S. Fallah, Dora Szarics, Dora Szarics, Clara M. Robson, Clara M. Robson, James H. Eubanks, James H. Eubanks, James H. Eubanks, James H. Eubanks, James H. Eubanks   +10 more
doaj   +1 more source

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

Cells, 2020
The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law, Fatima Valdes-Mora, David Gallego-Ortega   +2 more
doaj   +1 more source

Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence [PDF]

Open Biology, 2018
Pioneer transcription factors specifically target their recognition DNA sequences within nucleosomes. FoxA is the pioneer transcription factor that binds to the ALB1 gene enhancer in liver precursor cells, and is required for liver differentiation in ...
Yoshimasa Takizawa, Hiroki Tanaka, Shinichi Machida, Masako Koyama, Kazumitsu Maehara, Yasuyuki Ohkawa, Paul A. Wade, Matthias Wolf, Hitoshi Kurumizaka   +8 more
doaj   +1 more source

Progressive Phosphorylation Modulates the Self-Association of a Variably Modified Histone H3 Peptide

Frontiers in Molecular Biosciences, 2021
Protein phosphorylation is a key regulatory mechanism in eukaryotic cells. In the intrinsically disordered histone tails, phosphorylation is often a part of combinatorial post-translational modifications and an integral part of the “histone code” that ...
George V. Papamokos, George V. Papamokos, George V. Papamokos, George Tziatzos, Dimitrios G. Papageorgiou, Spyros Georgatos, Spyros Georgatos, Efthimios Kaxiras, Anastasia S. Politou, Anastasia S. Politou   +9 more
doaj   +1 more source

The First Analysis of Synaptonemal Complexes in Jawless Vertebrates: Chromosome Synapsis and Transcription Reactivation at Meiotic Prophase I in the Lamprey Lampetra fluviatilis (Petromyzontiformes, Cyclostomata)

Life, 2023
Transcription is known to be substage-specific in meiotic prophase I. If transcription is reactivated in the mid pachytene stage in mammals when synapsis is completed, then this process is observed in the zygotene stage in insects.
Sergey Matveevsky, Nikolay Tropin, Aleksandr Kucheryavyy, Oxana Kolomiets   +3 more
doaj   +1 more source

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution [PDF]

, 2013
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a ...
Andrew Bowman, Andrew Stirling, Andrews, Berndsen, Bonangelino, Bowman, Colin M. Hammond, Das, David A. Robinson, David G. Norman, Del Rosario, Dmitri I. Svergun, Driscoll, D’Arcy, D’Arcy, Fillingham, Fleissner, Hagelueken, Hansen, Hassane El-Mkami, Ishimi, Jeschke, Kolonko, Konarev, Krogan, Kuryan, Laskey, McBryant, McBryant, Milov, Newman, Noda, Ohkuni, Park, Park, Petoukhov, Pramila, Ransom, Richard Ward, Roessle, Schwieters, Selth, Selth, Su, Svergun, Svergun, Tang, Tang, Tom Owen-Hughes, Toth, Tsubota, Ward, Weifeng Shang, Xue   +53 more
core   +8 more sources

Heparin Attenuates Histone-Mediated Cytotoxicity in Septic Acute Kidney Injury

Frontiers in Medicine, 2020
Histones are considered potential risk factors that contribute to the development of septic acute kidney injury (SAKI) by inducing apoptosis and inflammation.
Ziyi Wang, Lijun Wang, Chao Cao, Heng Jin, Yan Zhang, Yancun Liu, Yulei Gao, Xue Liang, Guangping Li, Songtao Shou   +9 more
doaj   +1 more source

Reciprocal intronic and exonic histone modification regions in humans. [PDF]

, 2010
While much attention has been focused on chromatin at promoters and exons, human genes are mostly composed of intronic sequences. Analyzing published surveys of nucleosomes and 41 chromatin marks in humans, we identified histone modifications ...
Guthrie, Christine, Huff, Jason T, Plocik, Alex M, Yamamoto, Keith R   +3 more
core   +2 more sources