Results 1 to 10 of about 202,604 (264)
Roles and regulation of histone methylation in animal development
Nature Reviews Molecular Cell Biology, 2019 Histone methylation can occur at various sites in histone proteins, primarily on lysine and arginine residues, and it can be governed by multiple positive and negative regulators, even at a single site, to either activate or repress transcription.
Ashwini Jambhekar +2 more
exaly +2 more sources
The roles of histone variants in fine-tuning chromatin organization and function
Nature Reviews Molecular Cell Biology, 2020 Histones serve to both package and organize DNA within the nucleus. In addition to histone post-translational modification and chromatin remodelling complexes, histone variants contribute to the complexity of epigenetic regulation of the genome.
Sara Martire +2 more
exaly +2 more sources
DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation
Cell Reports, 2021 Summary: Histone lysine methylation functions at the interface of the extracellular environment and intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known ...
Tanjing Song +9 more
doaj +1 more source
Journal of Integrative Agriculture, 2023 Chromatin accessibility plays a vital role in gene transcriptional regulation. However, the regulatory mechanism of chromatin accessibility, as well as its role in regulating crucial gene expression and kernel development in maize (Zea mays) are poorly ...
Si-di XIE +8 more
doaj +1 more source
Frontiers in Genetics, 2021 Epigenetic processes are critical for governing the complex spatiotemporal patterns of gene expression in neurodevelopment. One such mechanism is the dynamic network of post-translational histone modifications that facilitate recruitment of transcription
Merrick S. Fallah +10 more
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Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer
Cells, 2020 The emergence of immunotherapy has been an astounding breakthrough in cancer treatments. In particular, immune checkpoint inhibitors, targeting PD-1 and CTLA-4, have shown remarkable therapeutic outcomes.
Andrew M. K. Law +2 more
doaj +1 more source
Autophagy, 2023 Bevacizumab plays an important role in the first and second line treatment for metastatic colorectal cancer (CRC). And induction of hypoxia and the tumors response to it plays an important role in determining the efficacy of antiangiogenic therapy while ...
Weihao Li +15 more
semanticscholar +1 more source
Cryo-EM structure of the nucleosome containing the ALB1 enhancer DNA sequence [PDF]
Open Biology, 2018 Pioneer transcription factors specifically target their recognition DNA sequences within nucleosomes. FoxA is the pioneer transcription factor that binds to the ALB1 gene enhancer in liver precursor cells, and is required for liver differentiation in ...
Yoshimasa Takizawa +8 more
doaj +1 more source
Cell Metabolism, 2023 SUMMARY Lactate was implicated in the activation of hepatic stellate cells (HSCs). However, the mechanism by which lactate exerts its effect remains elusive.
H. Rho +3 more
semanticscholar +1 more source
Progressive Phosphorylation Modulates the Self-Association of a Variably Modified Histone H3 Peptide
Frontiers in Molecular Biosciences, 2021 Protein phosphorylation is a key regulatory mechanism in eukaryotic cells. In the intrinsically disordered histone tails, phosphorylation is often a part of combinatorial post-translational modifications and an integral part of the “histone code” that ...
George V. Papamokos +9 more
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