Results 41 to 50 of about 557,726 (316)
Trichostatin A induces 5-lipoxygenase promoter activity and mRNA expression via inhibition of histone deacetylase 2 and 3 [PDF]
, 2012 The 5-lipoxygenase (5-LO) is the key enzyme in the formation of leukotrienes. We have previously shown that the histone deacetylase (HDAC) inhibitor trichostatin A (TSA) activates 5-LO transcription via recruitment of Sp1, Sp3 and RNA polymerase II to ...
Julia Metzner +13 more
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Histones and histone modifications in protozoan parasites
Cellular Microbiology, 2006 Protozoan parasites are early branching eukaryotes causing significant morbidity and mortality in humans and livestock. Single-celled parasites have evolved complex life cycles, which may involve multiple host organisms, and strategies to evade host immune responses.
William J, Sullivan +2 more
openaire +2 more sources
New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma [PDF]
, 2008 The anti-epileptic drug valproic acid is also under trial as an anti-cancer agent due to its histone deacetylase (HDAC) inhibitory properties. However, the effects of valproic acid (VPA) are limited and concentrations required for exerting anti ...
P. D. Soldato +17 more
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Journal of Applied Botany and Food Quality, 2013 Flavanols as a small subclass of the flavonoids stain selectively blue with the special reagent p-dimethylaminocinnamaldehyde (DMACA). Because of the prominent blue colour it is easy to recognize the flavanols histochemically in the vacuoles of expanding
Jürgen Polster +4 more
doaj +1 more source
Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]
, 2014 Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Batie, Michael +3 more
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New Insights in Transcriptional Regulation of the Ethylene Response in Arabidopsis
Frontiers in Plant Science, 2019 As any living organisms, plants must respond to a wide variety of environmental stimuli. Plant hormones regulate almost all aspects of plant growth and development.
Likai Wang +3 more
doaj +1 more source
Nucleus, 2023 Histone locus bodies (HLBs) are biomolecular condensates that assemble at replication-dependent (RD) histone genes in animal cells. These genes produce unique mRNAs that are not polyadenylated and instead end in a conserved 3’ stem loop critical for ...
Mark S. Geisler +2 more
doaj +1 more source
Role of histone methylation in paternal transmission of epigenetic information [PDF]
, 2010 During the development of multi-cellular organisms, one genome gives rise to multiple differentiated cell types. This is achieved by sequence specific transcription factors and different epigenetic mechanisms, which collaborate in reading the genetic ...
Brykczynska, Urszula
core +1 more source
Pharmacological Inhibition of LSD1 for Cancer Treatment
Molecules, 2018 Lysine-specific demethylase 1A (LSD1, also named KDM1A) is a demethylase that can remove methyl groups from histones H3K4me1/2 and H3K9me1/2. It is aberrantly expressed in many cancers, where it impedes differentiation and contributes to cancer cell ...
Guan-Jun Yang +4 more
doaj +1 more source
The histone H3 lysine 36 methyltransferase HypB facilitates embryonic stem cell differentiation [PDF]
, 2007 Histone H3 lysine 36 (H3K36) methylation was identified as a conserved modification from yeast to human. In yeast, biochemical characterization of the SET2 protein and genome wide mapping of H3K36me2 and K36me3 indicate that H3K36 methylation functions ...
Wang, Tianke
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