Results 21 to 30 of about 714,644 (288)

The Secret Language of Destiny: Stress Imprinting and Transgenerational Origins of Disease

Frontiers in Genetics, 2012
Epigenetic regulation modulates gene expression without altering the DNA sequence to facilitate rapid adjustments according to current environmental conditions.
Fabiola Cristina Ribeiro Zucchi, Youli eYao, Youli eYao, Gerlinde A.S. Metz   +3 more
doaj   +1 more source

Determinants of a transcriptionally competent environment at the GM-CSF promoter [PDF]

, 2015
Granulocyte macrophage-colony stimulating factor (GM-CSF) is produced by T cells, but not B cells, in response to immune signals. GM-CSF gene activation in response to T-cell stimulation requires remodelling of chromatin associated with the gene ...
Brettingham-Moore, Kate H, Chen, Xinxin, Holloway, Adele F, Oakford, P, Shannon, M Frances, Sprod, O R   +5 more
core   +1 more source

Molecular Insights into Epigenetics and Cannabinoid Receptors

Biomolecules, 2022
The actions of cannabis are mediated by G protein-coupled receptors that are part of an endogenous cannabinoid system (ECS). ECS consists of the naturally occurring ligands N-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol (2-AG), their ...
Balapal S. Basavarajappa, Shivakumar Subbanna   +1 more
doaj   +1 more source

MicroRNAs as new Characters in the Plot between Epigenetics and Prostate Cancer

Frontiers in Genetics, 2011
Prostate cancer (PCA) still represents a leading cause of death. An increasing number of studies have documented that microRNAs (miRNAs), a subgroup of non-coding RNAs with gene regulatory functions, are differentially expressed in PCA respect to the ...
Alessio ePaone, Roberta eGalli, Muller eFabbri   +2 more
doaj   +1 more source

The reduced expression of trimethylation of histone H3 at lysine 27 in primary cutaneous mucinous carcinoma

Dermatologica Sinica, 2023
Primary cutaneous mucinous carcinoma (PCMC) is rare, and its carcinogenesis is unclear. Trimethylation of histone H3 at lysine 27 (H3K27me3) is a key regulator in chromatin remodeling-controlled transcription.
Shu-Hao Li, Chien-Chun Chiou, Chien-Chin Chen   +2 more
doaj   +1 more source

Epigenetic Alterations in Human Papillomavirus-Associated Cancers

Viruses, 2017
Approximately 15–20% of human cancers are caused by viruses, including human papillomaviruses (HPVs). Viruses are obligatory intracellular parasites and encode proteins that reprogram the regulatory networks governing host cellular signaling pathways ...
David Soto, Christine Song, Margaret E. McLaughlin-Drubin   +2 more
doaj   +1 more source

Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]

, 2014
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi, Agger, Agger, Aik, Alena Shmakova, Allen, Banka, Barrett, Bersten, Beyer, Black, Clifton, Cloos, Copur, Couture, Cox, Curtis, Dalvai, De Santa, De Santa, Ehrbrecht, Elkins, Ene, Frescas, Frescas, Fukuda, Gearhart, Gildea, Grasso, Hayami, He, Hong, Inagaki, Ivan, Iwamori, Iwase, Jaakkola, Jensen, Jimena Druker, Johnson, Jones, Kauffman, Kenneth, Kleine-Kohlbrecher, Klose, Klose, Koivunen, Kooistra, Kottakis, Krieg, Krieser, Kruidenier, Lagarou, Lan, Lando, Laumonnier, Lee, Lee, Lee, Lee, Li, Liu, Lleres, Lorbeck, Lu, Maltby, Maxwell, Melvin, Melvin, Menon, Michael Batie, Mole, Moniz, Motoyama, Musselman, Narlikar, Niu, Oh, Okada, Okuno, Okuno, Osada, Owen-Hughes, Patani, Pfau, Pollard, Pryor, Ratcliffe, Rivera, Robinson, Robinson, Rocha, Rose, Rotili, Sanchez-Fernandez, Santos, Satoh, Sayegh, Schiller, Schnetz, Schodel, Scibetta, Scibetta, Semenza, Semenza, Shi, Shi, Sonia Rocha, Suzuki, Swygert, Tahiliani, Takeuchi, Tateishi, Tausendschön, Teng, Thinnes, Tie, Trewick, Tsukada, Tsukada, Tzatsos, Tzschach, Vinatzer, Wagner, Wang, Wang, Wang, Weber, Wellmann, Whetstine, Wissmann, Woon, Wozniak, Yamane, Yang, Yates, Yu, Zentner, Zhang, Zhou   +139 more
core   +5 more sources

Similarities between the Epstein-Barr Virus (EBV) Nuclear Protein EBNA1 and the Pioneer Transcription Factor FoxA: Is EBNA1 a “Bookmarking” Oncoprotein that Alters the Host Cell Epigenotype?

Pathogens, 2012
EBNA1, a nuclear protein expressed in all EBV-associated neoplasms is indispensable for the maintenance of the viral episomes in latently infected cells.
Hans Helmut Niller, Janos Minarovits
doaj   +1 more source

Esperanto for histones : CENP-A, not CenH3, is the centromeric histone H3 variant [PDF]

, 2013
The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease.
A. D. McAinsh, A. Desai, A. F. Straight, A. Losada, A. Musacchio, B. A. Sullivan, B. E. Black, B. G. Mellone, B. R. Brinkley, BA Sullivan, C. E. Sunkel, C. E. Walczak, CJ Lawrence, D. Foltz, D. M. Glover, D. W. Cleveland, D. W. Gerlich, DK Palmer, DR Foltz, E. D. Salmon, ES Alnemri, G. J. Gorbsky, G. J. P. L. Kops, G. Karpen, G. P. Copenhaver, H. F. Willard, H. Maiato, H. Masumoto, I. M. Cheeseman, J Ohzeki, J. G. DeLuca, J. R. Swedlow, K. Bloom, K. C. Scott, K. F. Sullivan, K. H. A. Choo, K. Luger, K. Oegema, K. Yoda, KF Sullivan, L. E. T. Jansen, L. Wordeman, M. A. Lampson, M. Fitzgerald-Hayes, M. Yanagida, MD Blower, P. E. Warburton, P. Heun, P. Meraldi, P. S. Maddox, P. T. Stukenberg, PB Talbert, R. C. Allshire, R. Gassmann, R. J. O’Neill, R. L. Margolis, S Ando, S Henikoff, S Stoler, S. C. Harrison, S. Diekmann, S. Erhardt, S. M. Lens, S. Westermann, SA Ribeiro, T Hori, T Nishino, T. Fukagawa, T. Hirota, T. J. Yen, W. Brown, W. C. Earnshaw, WC Earnshaw   +72 more
core   +9 more sources

Histone chaperones regulate histone exchange during transcription [PDF]

The EMBO Journal, 2007
Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway,
Hye-Jin, Kim, Ja-Hwan, Seol, Jeung-Whan, Han, Hong-Duk, Youn, Eun-Jung, Cho   +4 more
openaire   +2 more sources