Results 11 to 20 of about 202,604 (264)

Histones and histone modifications [PDF]

Current Biology, 2004
Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Peterson, Craig L, Laniel, Marc-André
openaire   +2 more sources

Histone clipping: the punctuation in the histone code [PDF]

EMBO reports, 2021
Histone clipping was first discovered in the 1960s and still is a lingering mystery. Considering the essential roles of histones in regulating eukaryotic transcription through the histone code, clipping is a post-translational modification that appeals to the imagination.
openaire   +2 more sources

Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma

Genome Biology, 2021
Background Histone lactylation, a metabolic stress-related histone modification, plays an important role in the regulation of gene expression during M1 macrophage polarization.
Jie Yu, P. Chai, Minyue Xie, S. Ge, Jing Ruan, Xianqun Fan, Renbing Jia   +6 more
semanticscholar   +2 more sources

Histone methylation: a dynamic mark in health, disease and inheritance

Nature Reviews Genetics, 2012
Eric Lieberman Greer
exaly   +2 more sources

The First Analysis of Synaptonemal Complexes in Jawless Vertebrates: Chromosome Synapsis and Transcription Reactivation at Meiotic Prophase I in the Lamprey Lampetra fluviatilis (Petromyzontiformes, Cyclostomata)

Life, 2023
Transcription is known to be substage-specific in meiotic prophase I. If transcription is reactivated in the mid pachytene stage in mammals when synapsis is completed, then this process is observed in the zygotene stage in insects.
Sergey Matveevsky, Nikolay Tropin, Aleksandr Kucheryavyy, Oxana Kolomiets   +3 more
doaj   +1 more source

Metabolic regulation of gene expression by histone lactylation

Nature, 2019
The Warburg effect, which originally described increased production of lactate in cancer, is associated with diverse cellular processes such as angiogenesis, hypoxia, polarization of macrophages and activation of T cells.
Di Zhang, Zhanyun Tang, He Huang, He Huang, Guolin Zhou, Chang Cui, Yejing Weng, Wenchao Liu, Sunjoo Kim, Sangkyu Lee, Mathew Perez-Neut, Jun Ding, Daniel M. Czyż, Rong Hu, Z. Ye, Maomao He, Y. G. Zheng, H. Shuman, Lunzhi Dai, Lunzhi Dai, B. Ren, R. Roeder, L. Becker, Yingming Zhao   +23 more
semanticscholar   +1 more source

Heparin Attenuates Histone-Mediated Cytotoxicity in Septic Acute Kidney Injury

Frontiers in Medicine, 2020
Histones are considered potential risk factors that contribute to the development of septic acute kidney injury (SAKI) by inducing apoptosis and inflammation.
Ziyi Wang, Lijun Wang, Chao Cao, Heng Jin, Yan Zhang, Yancun Liu, Yulei Gao, Xue Liang, Guangping Li, Songtao Shou   +9 more
doaj   +1 more source

High-resolution profiling of histone methylations in the human genome.

Cell, 2007
Histone modifications are implicated in influencing gene expression. We have generated high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine methylations as well as histone variant H2A.Z, RNA polymerase II, and the ...
A. Barski, Suresh Cuddapah, Kairong Cui, Tae-Young Roh, Dustin E. Schones, Zhibin Wang, Gang Wei, I. Chepelev, K. Zhao   +8 more
semanticscholar   +1 more source

Histone Lactylation Boosts Reparative Gene Activation Post–Myocardial Infarction

Circulation Research, 2022
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals.
Naixin Wang, Weiwei Wang, Xiaoqi Wang, G. Mang, Jianfeng Chen, Xiangyu Yan, Zhonghua Tong, Qiannan Yang, Mengdi Wang, Liangqi Chen, Ping Sun, Yupeng Yang, Jingxuan Cui, Mian Yang, Yafei Zhang, Dongni Wang, Jian Wu, Maomao Zhang, Bo Yu   +18 more
semanticscholar   +1 more source

Class I histone deacetylases (HDAC1–3) are histone lysine delactylases

bioRxiv, 2021
Lysine l-lactylation [K(l-la)] is a newly discovered histone mark that can be stimulated under conditions of high glycolysis, such as the Warburg effect. K(l-la) is associated with functions that are different from the widely studied histone acetylation.
C. Moreno-Yruela, Di Zhang, Wei Wei, Michael Bæk, Wenchao Liu, Jinjun Gao, D. Danková, Alexander L. Nielsen, Julie E Bolding, Lu Yang, Samuel T. Jameson, J. Wong, C. Olsen, Yingming Zhao   +13 more
semanticscholar   +1 more source