Results 11 to 20 of about 714,644 (288)
Histones and histone modifications [PDF]
Current Biology, 2004 Histone variants, distinct patterns of posttranslational modifications of histones, and histone tail binding proteins all contribute to establishment of various ‘open’ or ‘closed’ chromatin domains that have specialized folding properties and biological functions. Some of these domains can be propagated through DNA replication and mitosis, guaranteeing
Peterson, Craig L, Laniel, Marc-André
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Histone-Histone Interactions and Centromere Function [PDF]
Molecular and Cellular Biology, 2000 Cse4p is a structural component of the core centromere of Saccharomyces cerevisiae and is a member of the conserved CENP-A family of specialized histone H3 variants. The histone H4 allele hhf1-20 confers defects in core centromere chromatin structure and mitotic chromosome transmission.
L, Glowczewski +4 more
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Point Mutations in Centromeric Histone Induce Post-zygotic Incompatibility and Uniparental Inheritance. [PDF]
, 2015 The centromeric histone 3 variant (CENH3, aka CENP-A) is essential for the segregation of sister chromatids during mitosis and meiosis. To better define CENH3 functional constraints, we complemented a null allele in Arabidopsis with a variety of mutant ...
Britt, Anne B +6 more
core +9 more sources
Early Life Stress- and Drug-Induced Histone Modifications Within the Ventral Tegmental Area
Frontiers in Cell and Developmental Biology, 2020 Psychiatric illnesses are a major public health concern due to their prevalence and heterogeneity of symptom presentation resulting from a lack of efficacious treatments.
Ryan D. Shepard, Fereshteh S. Nugent
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Histones, histone chaperones and nucleosome assembly [PDF]
Protein & Cell, 2010 Chromatin structure governs a number of cellular processes including DNA replication, transcription, and DNA repair. During DNA replication, chromatin structure including the basic repeating unit of chromatin, the nucleosome, is temporarily disrupted, and then reformed immediately after the passage of the replication fork.
Rebecca J, Burgess, Zhiguo, Zhang
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Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks. [PDF]
, 2012 Recruitment of 53BP1 to chromatin flanking double strand breaks (DSBs) requires γH2AX/MDC1/RNF8-dependent ubiquitination of chromatin and interaction of 53BP1 with histone H4 methylated on lysine 20 (H4K20me). Several histone methyltransferases have been
Guan, Yinghua +7 more
core +8 more sources
Molecules, 2018 With the increasing interest in scarce proteins, reducing the sample volume for circular dichroism (CD) spectroscopy has become desirable. Demagnification of the incident beam size is required to reduce the sample volume for CD spectroscopy detecting ...
Yudai Izumi, Koichi Matsuo
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HDAC4 regulates skeletal muscle regeneration via soluble factors [PDF]
, 2018 Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Alessandra Renzini +5 more
core +3 more sources
Acetylated histone variant H2A.Z is involved in the activation of neo-enhancers in prostate cancer
Nature Communications, 2017 Acetylation of the histone variant H2A.Z at gene promoters is associated with oncogene activation; however, it is unclear if such modification has a role in regulating the function of enhancers.
Fátima Valdés-Mora +18 more
doaj +1 more source
Frontiers in Endocrinology, 2018 Gonadotropin-releasing hormone (GnRH) stimulates the expression of multiple genes in the pituitary gonadotropes, most notably to induce synthesis of the gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), but also to ensure ...
Philippa Melamed +6 more
doaj +1 more source