Results 31 to 40 of about 714,644 (288)

Epigenetic Regulation of Autophagy: A Path to the Control of Autoimmunity

Frontiers in Immunology, 2018
Autoimmune diseases are a significant cause of debilitation and mortality globally and are in need of cost-effective therapeutics. Autophagy is a cellular pathway that facilitates immune modulation involved in both pathogen control and autoimmunity ...
Jessica C. Hargarten, Peter R. Williamson   +1 more
doaj   +1 more source

Epigenetic Modifications to H3K9 in Renal Tubulointerstitial Cells after Unilateral Ureteric Obstruction and TGF-β1 Stimulation

Frontiers in Pharmacology, 2017
Introduction: Epigenetic regulation of fibrogenesis through post-translational histone modifications (marks) may be a key determinant of progression in renal disease. In this study, we examined the distribution and acquisition of histone 3 Lysine 9 (H3K9)
Timothy D. Hewitson, Timothy D. Hewitson, Stephen G. Holt, Stephen G. Holt, Sven-Jean Tan, Belinda Wigg, Chrishan S. Samuel, Edward R. Smith, Edward R. Smith   +8 more
doaj   +1 more source

Association of Histones With Coagulofibrinolytic Responses and Organ Dysfunction in Adult Post-cardiac Arrest Syndrome

Frontiers in Cardiovascular Medicine, 2022
BackgroundPatients successfully resuscitated from cardiac arrest often develop organ dysfunction caused by systemic inflammation and increased coagulation, leading to disseminated intravascular coagulation (DIC).
Asumi Mizugaki, Takeshi Wada, Takumi Tsuchida, Satoshi Gando, Satoshi Gando   +4 more
doaj   +1 more source

A length-dynamic Tonks gas theory of histone isotherms

, 2002
We find exact solutions to a new one-dimensional (1D) interacting particle theory and apply the results to the adsorption and wrapping of polymers (such as DNA) around protein particles (such as histones).
Marko J. F., Piasecki J., Poland D., Sinden R. R., Thompson C., Tom Chou, Vilfan A., Vilfan A., Widom J.   +8 more
core   +1 more source

Methylated DNMT1 and E2F1 Are Targeted for Proteolysis by L3MBTL3 and CRL4DCAF5 Ubiquitin Ligase [PDF]

, 2018
Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves ...
Alejo, Salvador, Hoang, Nam, Leng, Feng, Lu, Fei, Sun, Hong, Yu, Jiekai, Zhang, Chunxiao, Zhang, Hui   +7 more
core   +3 more sources

Flavanols in the nuclei of the tea bush (Camellia sinensis) - broadening the perspectives to human health

Journal of Applied Botany and Food Quality, 2013
Flavanols as a small subclass of the flavonoids stain selectively blue with the special reagent p-dimethylaminocinnamaldehyde (DMACA). Because of the prominent blue colour it is easy to recognize the flavanols histochemically in the vacuoles of expanding
Jürgen Polster, Walter Feucht, Markus Schmid, H. Dithmar, Dieter Treutter   +4 more
doaj   +1 more source

Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]

, 1988
The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the ...
Alberts, Bookout, Ebeling, Einck, Everett, Faber, Freeman, Green, Günther M. Keil, Hay, Hermiston, Isenberg, Kedes, Keil, Keil, Keil, Keil, Konrad Munch, Koszinowski, Koszinowski, Koszinowski, Kristie, Kristie, Martin Messerle, O'Hare, Ohlenbusch, Purifoy, Reddehase, Rigby, Stein, Tevethia, Ulrich H. Koszinowski, Weissbach   +32 more
core   +1 more source

New Insights in Transcriptional Regulation of the Ethylene Response in Arabidopsis

Frontiers in Plant Science, 2019
As any living organisms, plants must respond to a wide variety of environmental stimuli. Plant hormones regulate almost all aspects of plant growth and development.
Likai Wang, Likai Wang, Hong Qiao, Hong Qiao   +3 more
doaj   +1 more source

Histone locus bodies: a paradigm for how nuclear biomolecular condensates control cell cycle regulated gene expression

Nucleus, 2023
Histone locus bodies (HLBs) are biomolecular condensates that assemble at replication-dependent (RD) histone genes in animal cells. These genes produce unique mRNAs that are not polyadenylated and instead end in a conserved 3’ stem loop critical for ...
Mark S. Geisler, James P. Kemp, Robert J. Duronio   +2 more
doaj   +1 more source

Activation of AMP-activated protein kinase by metformin induces protein acetylation in prostate and ovarian cancer cells [PDF]

, 2016
AMP-activated protein kinase (AMPK) is an energy sensor and master regulator of metabolism. AMPK functions as a fuel gauge monitoring systemic and cellular energy status.
Galdieri, Luciano, Gatla, Himavanth, Vancura, Ales, Vancurova, Ivana   +3 more
core   +2 more sources