Results 31 to 40 of about 202,604 (264)
MicroRNAs as new Characters in the Plot between Epigenetics and Prostate Cancer
Frontiers in Genetics, 2011 Prostate cancer (PCA) still represents a leading cause of death. An increasing number of studies have documented that microRNAs (miRNAs), a subgroup of non-coding RNAs with gene regulatory functions, are differentially expressed in PCA respect to the ...
Alessio ePaone +2 more
doaj +1 more source
The Histone Database: an integrated resource for histones and histone fold-containing proteins [PDF]
Database, 2011 Eukaryotic chromatin is composed of DNA and protein components-core histones-that act to compactly pack the DNA into nucleosomes, the fundamental building blocks of chromatin. These nucleosomes are connected to adjacent nucleosomes by linker histones. Nucleosomes are highly dynamic and, through various core histone post-translational modifications and ...
Leonardo Mariño-Ramírez +6 more
openaire +2 more sources
Dermatologica Sinica, 2023 Primary cutaneous mucinous carcinoma (PCMC) is rare, and its carcinogenesis is unclear. Trimethylation of histone H3 at lysine 27 (H3K27me3) is a key regulator in chromatin remodeling-controlled transcription.
Shu-Hao Li +2 more
doaj +1 more source
Epigenetic Alterations in Human Papillomavirus-Associated Cancers
Viruses, 2017 Approximately 15–20% of human cancers are caused by viruses, including human papillomaviruses (HPVs). Viruses are obligatory intracellular parasites and encode proteins that reprogram the regulatory networks governing host cellular signaling pathways ...
David Soto +2 more
doaj +1 more source
Pathogens, 2012 EBNA1, a nuclear protein expressed in all EBV-associated neoplasms is indispensable for the maintenance of the viral episomes in latently infected cells.
Hans Helmut Niller, Janos Minarovits
doaj +1 more source
EMBO reports, 2020 Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post-translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. However, the role of HAT1 in succinylation modulation remains unclear.
Guang Yang +14 more
openaire +3 more sources
The histone database: A comprehensive resource for histones and histone fold‐containing proteins [PDF]
Proteins: Structure, Function, and Bioinformatics, 2005 AbstractTheThe Histone Database is a curated and searchable collection of full‐length sequences and structures of histones and nonhistone proteins containing histone‐like folds, compiled from major public databases. Several new histone fold‐containing proteins have been identified, including the huntingtin‐interacting protein HYPM.
Leonardo, Mariño-Ramírez +3 more
openaire +2 more sources
Epigenetic Regulation of Autophagy: A Path to the Control of Autoimmunity
Frontiers in Immunology, 2018 Autoimmune diseases are a significant cause of debilitation and mortality globally and are in need of cost-effective therapeutics. Autophagy is a cellular pathway that facilitates immune modulation involved in both pathogen control and autoimmunity ...
Jessica C. Hargarten +1 more
doaj +1 more source
Frontiers in Pharmacology, 2017 Introduction: Epigenetic regulation of fibrogenesis through post-translational histone modifications (marks) may be a key determinant of progression in renal disease. In this study, we examined the distribution and acquisition of histone 3 Lysine 9 (H3K9)
Timothy D. Hewitson +8 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2022 BackgroundPatients successfully resuscitated from cardiac arrest often develop organ dysfunction caused by systemic inflammation and increased coagulation, leading to disseminated intravascular coagulation (DIC).
Asumi Mizugaki +4 more
doaj +1 more source