Results 111 to 120 of about 138,386 (301)
, 2017 IgGs against H2a and H2b histones from HIV-infected patients specifically hydrolysed only histones but not many other tested globular proteins.
Nikita V. Ivanisenko +4 more
core +1 more source
Advanced Science, EarlyView.Mechanical stress activates BAP31 in chondrocytes. BAP31 competes with ATG14 for binding to STX17, disrupting the STX17–ATG14 complex required for autophagosome–lysosome fusion. The resultant autophagic flux blockade drives the generation of autophagy‐derived exosomes, which mediate pathological cartilage calcification in OA. Chondrocyte‐targeted BAP31
Zhi‐hua Xu +13 more
wiley +1 more source
Progress in the treatment of pediatric H3 K27M mutant diffuse midline glioma
Chinese Journal of Contemporary Neurology and Neurosurgery, 2020 The high-grade glioma, H3 K27M mutant diffuse midline glioma tends to occur in children, and its high malignancy lead to very poor prognosis after treatment (median survival after diagnosis < 1 year).
Min⁃jie LUO +2 more
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Hyperacetylated histones facilitate chromatin assembly in vitro
, 1985 We have examined the effect of histone acetylation on the in vitro assembly of nucleosomes with DNA and purified histones at physiological ionic strength in the presence of polyglutamic acid.
Chalkley, Roger, Cotten, Matt
core +1 more source
Advanced Science, EarlyView.Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li +8 more
wiley +1 more source
Histones induce epithelial and endothelial cell death.
, 2012 (A) A549 cells were treated for 16 h with different concentrations of histone type II-A, and the cell morphology was evaluated. (B) A549 cell numbers were counted after treatment with various concentrations of histones for 16 h.
Sebastian P. Galuska (180803) +7 more
core +1 more source
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
Extracellular histones induce erythrocyte fragility and anemia
, 2017 Key Points Histones promote in vitro erythrocyte aggregation, sedimentation, fragility, and spleen retention in a concentration-dependent manner.
Lucy A. Coupland +4 more
core +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
The primary structure of histones H2B from sperm of the sea urchins Parechinus angulosus and Psammechinus miliaris [PDF]
, 1978 Histones H2B have been purified from sperm of the sea urchin Parechinus angulosus and Psammechinus miliaris. Three H2B variants have been completely sequenced from P. angulosus and two H2B variants from P. miliaris have been partially sequenced.
Strickland, Marie Shields
core +1 more source