Results 131 to 140 of about 129,047 (304)
Advanced Science, EarlyView.Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng +8 more
wiley +1 more source
Frontiers in Bioscience-LandmarkHistones were once thought to be exclusive to the nucleus, but were recently discovered in the extracellular space, where they play important roles in disease pathogenesis.
Danmei Zhang +4 more
doaj +1 more source
Total Chemical Synthesis of Modified Histones
, 2018 In the post-genome era, epigenetics has received increasing attentions in recent years. The post-translational modifications (PTMs) of four core histones play central roles in epigenetic regulation of eukaryotic genome by either directly altering the ...
Yi-Ming Li +3 more
core +1 more source
CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation
Advanced Science, EarlyView.ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu +10 more
wiley +1 more source
Histones induced phosphatidylserine exposure in endothelial cells.
, 2016 (A) EA.hy926 cells were stimulated with various levels of calf thymus histones for 4 h, and the surface phosphatidylserine level was determined by flow cytometer.
Hyun Kyung Kim (287966) +3 more
core +1 more source
Advanced Science, EarlyView.Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang +21 more
wiley +1 more source
The role of histone variants in chromatin structure and function in eukaryotes
The thesis focuses on the role played by histone variants in the structure and functioning of the chromosome of eukaryotes.It focuses on post translational modifications.It explores the role played by histones in nucleosome stability.It also looks at ...
Motloung, Matadiana Samuel
core
Biotin -dependent modifications of histones
, 2006 Post-translational modifications of histones (e.g. acetylation, methylation, phosphorylation and ubiquitination) are crucial for the regulation of chromatin structure and function; these modifications are thought to be interdependent, playing important ...
Camporeale, Gabriela
core
Histones induce epithelial and endothelial cell death.
, 2012 (A) A549 cells were treated for 16 h with different concentrations of histone type II-A, and the cell morphology was evaluated. (B) A549 cell numbers were counted after treatment with various concentrations of histones for 16 h.
Sebastian P. Galuska (180803) +7 more
core +1 more source
Advanced Science, EarlyView.OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao +12 more
wiley +1 more source