Results 121 to 130 of about 138,386 (301)

Purification of histones and binding to mitochondria.

, 2013
Panel A: histones extracted from rat liver nuclei by acid treatment were separated by reverse phase HPLC using a C18 column. All fractions were collected for analysis by MALDI TOF mass spectrometry and SDS-PAGE.
Ove Eriksson (88731), Paolo Bernardi (43477), Dan Lindholm (88729), Celine Bruelle (5652289), Annunziata Cascone (326305)   +4 more
core   +1 more source

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source

The Landscape of Long Non‐Coding RNAs Provides Insights Into the Domestication and Improvement of Pear Fruit

Advanced Science, EarlyView.
This study reveals that long non‐coding RNAs represent important regulatory components underlying pear domestication and improvement. Integrative multi‐omics analyses identify selected lncRNAs associated with fruit traits, while functional validation uncovers a lignin‐related lncRNA, lncRNA‐pys, that promotes lignin accumulation.
Bobo Song, Peilin Han, Jiaming Li, Xiaolong Li, Xiang Zhang, Jing Fan, Dongliang Liu, Jianfa Cai, Lingchao Zhang, Jun Wu   +9 more
wiley   +1 more source

Genome‐Wide and Multi‐Omics Analysis Identified DNA‐Interacting Circular RNA circFOXK2 as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Circular RNA circFOXK2 is frequently upregulated in pancreatic ductal adenocarcinoma to promote tumor heterogeneity, growth, and metastasis. Through circRNA‐DNA interaction at different genomic locations, circFOXK2 removes the PPIE inhibitory effects on MLL1 for gene‐activating H3K4 methylation of the oncogenes.
Chi Hin Wong, Jessica Jazmin Peña‐Paladines, Sum Yin Valerie Leung, Ka‐Fai To, Kenneth Siu Ho Chok, Yangchao Chen   +5 more
wiley   +1 more source

Stable circulating histone complexes for minimally invasive liquid biopsy diagnostics

Epigenetics Reports
The clinical utility of liquid biopsy biomarkers depends on their structural integrity and resistance to pre-analytical variability. Circulating histones have emerged as promising minimally invasive biomarkers across cancer, metabolic, and inflammatory ...
Nikola Kaštánková, Diana Buzova, Manlio Vinciguerra, Gabriela Lochmanová, Zbyněk Zdráhal, Jan Cerveny, Jan Frohlich   +6 more
doaj   +1 more source

Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies

Advanced Science, EarlyView.
This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan, Litao Wang, Tuuli‐Marjaana Koski, Lizhe An, Thomas Efferth, Yujie Fu   +5 more
wiley   +1 more source

Single‐Dose TACE‐Like Injection of Sustained‐Release Panobinostat/IL‐12 Polymeric Microparticles is Effective in Preclinical Liver Cancer Models

Advanced Science, EarlyView.
A novel PLGA/PBAE polymer microparticle platform revolutionizes intermediate‐stage liver cancer treatment by co‐delivering panobinostat and IL‐12 via a single TACE‐like injection. This sustained‐release system overcomes tumor immunosuppression, triggers robust innate and adaptive immune responses, and establishes tertiary lymphoid structures ...
Hongzhe Yu, Ling Li, Sachin S. Surwase, Xin Ming M. Zhou, Hongtao Qian, Joel C. Sunshine, Florin M. Selaru, Jordan J. Green   +7 more
wiley   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

The Role of Extracellular Histones in Disease Progression: A Potential Therapeutic Target for Disease Modulation

Frontiers in Bioscience-Landmark
Histones were once thought to be exclusive to the nucleus, but were recently discovered in the extracellular space, where they play important roles in disease pathogenesis.
Danmei Zhang, Yukun Wang, Jin Guo, Xiaoya Zhang, Zuojiong Gong   +4 more
doaj   +1 more source

Comparison of Rtt109-Vps75 mediated acetylation (1-h incubation) on individual lysines on H3 from chicken erythrocytes, recombinant Xenopus histones, or recombinant yeast histones.

, 2015
Acetylation percentage of each site was determined by targeted MS-based method. The black and white bars depict the acetylation levels on recombinant Xenopus and yeast histones, respectively.
Liangqun Huang (703931), Ryan A. Henry (703930), Laurie A. Stargell (703932), Yin-Ming Kuo (381008), Andrew J. Andrews (381009), Xu Chen (432759)   +5 more
core   +1 more source