Results 121 to 130 of about 114,303 (263)

[Expression of Concern] Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects. [PDF]

Int J Oncol
Carlisi D, Vassallo B, Lauricella M, Emanuele S, D'anneo A, Di Leonardo E, Di Fazio P, Vento R, Tesoriere G.   +8 more
europepmc   +1 more source

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Emerging biomodels to understand the pathophysiology of sepsis and evaluate new therapeutic strategies targeting extracellular histones. [PDF]

Mater Today Bio
García-Gimenez JL, Seco Cervera M, Cánovas-Cervera I, Agúndez AB, Dolz-Andrés E, Mondaray-Muñoz G, Calpe-Fortea R, Nacher-Sendra E, Osca-Verdegal R, Aparicio-Collado JL, Beltrán-García J, Sierra-Rivera A, Peiró-Chova L, Gallego-Ferrer G, Ibañez-Cabellos JS.   +14 more
europepmc   +1 more source

Bioadhesive Hydrogel With Polyphenol‐Armored Nanogene Rejuvenates Chondrocyte Senescence for Aged Osteoarthritis Therapy

Advanced Science, EarlyView.
An adhesive hydrogel depot with polyphenol‐armored nanogenes is developed for treating aged osteoarthritis. This system maintains miR‐140 bioactivity, prolongs its intra‐articular retention, and enhances transfection into chondrocytes, leading to the downregulation of senescence‐associated pathways.
Liwei Yan, Runze Yang, Ting Zhou, Tianhao Xu, Yongqi Li, Yuelin Hu, Minghao Ge, Lei Zhang, Xiong Lu, Chaoming Xie, Weili Fu   +10 more
wiley   +1 more source

Regulation of histones in thromboinflammation. [PDF]

Front Immunol
Mohiuddin N, Shah Y, Subramaniam S.
europepmc   +1 more source

Histone lactylation [PDF]

Nature Immunology, 2019
openaire   +2 more sources

Tumor‐Infiltrating mregDCs Restrain Anti‐Tumor Immunity in Early Relapse HCC

Advanced Science, EarlyView.
Tumor‐infiltrating mregDCs are regulated by the TNFR2‐non‐canonical NF‐κB axis, which is mediated by TNF‐α secreted by CD161+CD8+ T cells. These mregDCs recruit CD161+CD8+ T cells via the CCL20‐CCR6 axis, forming a positive feedback loop that enhances immunosuppression, promotes early recurrence of HCC, and further confirms TNFR2 as a key therapeutic ...
Zefan Zhang, Lin Ding, Yu Zhong, Haokang Feng, Linglong Huang, Waidong Huang, Chunqing Wang, Arne Östman, Beili Wang, Jian Zhou, Jia Fan, Wei Guo, Liang Wu, Yunfan Sun   +13 more
wiley   +1 more source

The double histone fold: Structure, functional implications across the tree of life and relevance to protein design. [PDF]

Protein Sci
Ranaudo A, Miyake T, Cosentino U, Greco C.   +3 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Chromatin-derived histone proteins from <i>Schmidtea mediterranea</i> function as innate antimicrobial effectors. [PDF]

Front Cell Infect Microbiol
Nampoothiri D, Bhardwaj R, Deshpande N, Abnave P.   +3 more
europepmc   +1 more source