Results 1 to 10 of about 49,543 (299)
mSystems, 2021 Leishmania donovani is a parasitic protist that causes the lethal Kala-azar fever in India and East Africa. Gene expression in Leishmania is regulated by gene copy number variation and inducible translation while RNA synthesis initiates at a small number
Janne Grünebast +3 more
doaj +1 more source
, 2008 Sushma Shivaswamy is with UT Austin, Akshay Bhinge is with UT Austin, Yongjun Zhao is with British Columbia Cancer Agency, Steven Jones is with British Columbia Cancer Agency, Martin Hirst is with British Columbia Cancer Agency, Vishwanath R Iyer is with
Bhinge, Akshay +17 more
core +1 more source
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
eLife, 2016 The prokaryotic CRISPR (clustered regularly interspaced palindromic repeats)-associated protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating eukaryotic genomes.
Max A Horlbeck +8 more
doaj +1 more source
Making better CRISPR libraries
eLife, 2016 A new algorithm improves the performance of CRISPR-based genetic screens in mammals.
Shiyou Zhu, Wensheng Wei
doaj +1 more source
Mechanical properties of nucleoprotein complexes determined by nanoindentation spectroscopy
Nucleus, 2020 The interplay between transcription factors, chromatin remodelers, 3-D organization, and mechanical properties of the chromatin fiber controls genome function in eukaryotes.
Tatini Rakshit +3 more
doaj +1 more source
ATP-dependent chromatosome remodeling [PDF]
, 2008 Chromatin serves to package, protect and organize the complex eukaryotic genomes to assure their stable inheritance over many cell generations. At the same time, chromatin must be dynamic to allow continued use of DNA during a cell's lifetime.
Chioda, Mariacristina +2 more
core +1 more source
eLife, 2016 We recently found that nucleosomes directly block access of CRISPR/Cas9 to DNA (Horlbeck et al., 2016). Here, we build on this observation with a comprehensive algorithm that incorporates chromatin, position, and sequence features to accurately predict ...
Max A Horlbeck +10 more
doaj +1 more source
Revista Brasileira de Reumatologia, 2012 OBJETIVOS: Determinar a frequência de anticorpos contra componentes da cromatina no lúpus eritematoso sistêmico juvenil (LESJ) e correlacionar a presença desses autoanticorpos com manifestações clínicas e atividade da doença.
Silene Peres Keusseyan +5 more
doaj +1 more source
Plasma Nucleosomes in Primary Breast Cancer
, 2020 When cells die, nucleosomes composed of DNA and histone proteins enter the extracellular space and end eventually in the circulation. In plasma, they might serve as a nonspecific marker of cell death, potentially useful for noninvasive monitoring of ...
Gabriel Minarik +10 more
core +1 more source
Average level of nucleosomes vs. .
, 2013 The average level of nucleosomes is plotted as a function of for both and . These levels of nucleosomes are computed by averaging the final number of nucleosomes in the simulations over all the runs and the whole lattice.
Edward Ott (180528) +4 more
core +1 more source