Results 1 to 10 of about 109,383 (351)
Toward a molecular understanding of yeast silent chromatin : roles for H4K16 acetylation and the Sir3 C-terminus [PDF]
, 2012 Discrete regions of the eukaryotic genome assume a heritable chromatin structure that is refractory to gene expression. In budding yeast, silent chromatin is characterized by the loading of the Silent Information Regulatory (Sir) proteins (Sir2, Sir3 and
Oppikofer, Mariano
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Revista Brasileira de Reumatologia, 2012 OBJETIVOS: Determinar a frequência de anticorpos contra componentes da cromatina no lúpus eritematoso sistêmico juvenil (LESJ) e correlacionar a presença desses autoanticorpos com manifestações clínicas e atividade da doença.
Silene Peres Keusseyan +5 more
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HP1 reshapes nucleosome core to promote phase separation of heterochromatin [PDF]
, 2019 Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
Burlingame, AL +8 more
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A quantitative investigation of linker histone interactions with nucleosomes and chromatin
Scientific Reports, 2016 Linker histones such as H1 are abundant basic proteins that bind tightly to nucleosomes, thereby acting as key organizers of chromatin structure. The molecular details of linker histone interactions with the nucleosome and in particular the contributions
Alison E. White, Aaron R Hieb, K. Luger
semanticscholar +1 more source
Accessibility of promoter DNA is not the primary determinant of chromatin-mediated gene regulation [PDF]
, 2019 DNA accessibility is thought to be of major importance in regulating gene expression. We test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a proxy for transcription factors.
Chereji, Razvan V. +4 more
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Cell GenomicsSummary: Deep learning models have advanced our ability to predict cell-type-specific chromatin patterns from transcription factor (TF) binding motifs, but their application to perturbed contexts remains limited.
Sahin Naqvi +6 more
doaj +1 more source
Job Opening for Nucleosome Mechanic: Flexibility Required
Cells, 2020 The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer’s mechanical ...
Mary Pitman +2 more
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Circulating Nucleosomes and Histones in the Development of Lung Injury and Sepsis
Current Issues in Molecular BiologyCellular nucleosomes—the structural and functional units of chromatin—are inherently present in cells. During cellular damage or cell death, nucleosomes are released into circulation, either actively or passively.
Saugata Dutta +5 more
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PLoS ONE, 2021 The most basic level of eukaryotic gene regulation is the presence or absence of nucleosomes on DNA regulatory elements. In an effort to elucidate in vivo nucleosome patterns, in vitro studies are frequently used.
David A Bates +7 more
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The size of the nucleosome [PDF]
, 2011 The structural origin of the size of the 11 nm nucleosomal disc is addressed. On the nanometer length-scale the organization of DNA as chromatin in the chromosomes involves a coiling of DNA around the histone core of the nucleosome.
A. Travers +3 more
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