Results 11 to 20 of about 109,383 (351)
Mechanisms of OCT4-SOX2 motif readout on nucleosomes
Science, 2020 Engaging the nucleosome Cell identity is defined by gene expression patterns that are established through the binding of specific transcription factors.
Alicia K Michael +2 more
exaly +2 more sources
DNA damage detection in nucleosomes involves DNA register shifting
Nature, 2019 Access to DNA packaged in nucleosomes is critical for gene regulation, DNA replication and DNA repair. In humans, the UV-damaged DNA-binding protein (UV-DDB) complex detects UV-light-induced pyrimidine dimers throughout the genome; however, it remains ...
Syota Matsumoto +2 more
exaly +2 more sources
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
eLife, 2016 The prokaryotic CRISPR (clustered regularly interspaced palindromic repeats)-associated protein, Cas9, has been widely adopted as a tool for editing, imaging, and regulating eukaryotic genomes.
Max A Horlbeck +8 more
doaj +2 more sources
Asymmetrically Modified Nucleosomes [PDF]
Cell, 2012 Mononucleosomes, the basic building blocks of chromatin, contain two copies of each core histone. The associated posttranslational modifications regulate essential chromatin-dependent processes, yet whether each histone copy is identically modified in vivo is unclear.
Philipp Voigt, Gary LeRoy, Barry M Zee
exaly +4 more sources
BRD4 is a Histone Acetyltransferase that Evicts Nucleosomes from Chromatin
Nature Structural &Molecular Biology, 2016 Bromodomain protein 4 (BRD4) is a chromatin-binding protein implicated in cancer and autoimmune diseases that functions as a scaffold for transcription factors at promoters and super-enhancers.
B. N. Devaiah +8 more
semanticscholar +3 more sources
Science Advances, 2015 Reestablishment of the nucleosome landscape behind the replication fork is fundamental for epigenetic memory during development. Eukaryotic replication disrupts each nucleosome as the fork passes, followed by reassembly of disrupted nucleosomes and ...
S. Ramachandran, S. Henikoff
semanticscholar +3 more sources
A method for cryo-EM analysis of eukaryotic nucleosomes reconstituted in bacterial cells [PDF]
iScienceSummary: Conventional methods for preparing nucleosomes are time-consuming and technically demanding. In the present study, we extended the approach of generating nucleosomes in Escherichia coli by the co-expression of all four histones, allowing ...
Cheng-Han Ho +4 more
doaj +2 more sources
Chromatin Fibers Are Formed by Heterogeneous Groups of Nucleosomes In Vivo
Cell, 2015 Carlo Manzo +2 more
exaly +2 more sources
Histone dynamics mediate DNA unwrapping and sliding in nucleosomes
Nature Communications, 2021 Nucleosomes are elementary building blocks of chromatin in eukaryotes. They tightly wrap ∼147 DNA base pairs around an octamer of histone proteins. How nucleosome structural dynamics affect genome functioning is not completely clear.
G. Armeev +4 more
semanticscholar +1 more source
Pathogens, 2021 (1) Background: Hepatocellular carcinoma (HCC) is the most serious complication of chronic hepatitis B (CHB). Recently, the detection of circulating cell-free (cf) DNA and nucleosomes has found numerous applications in oncology.
Alkistis Papatheodoridi +4 more
doaj +1 more source