Results 11 to 20 of about 49,543 (299)
The Insulator Binding Protein CTCF Positions 20 Nucleosomes around Its Binding Sites across the Human Genome [PDF]
PLoS Genetics, 2008 Chromatin structure plays an important role in modulating the accessibility of genomic DNA to regulatory proteins in eukaryotic cells. We performed an integrative analysis on dozens of recent datasets generated by deep-sequencing and high-density tiling ...
Yutao Fu +2 more
exaly +2 more sources
CENP-A confers a reduction in height on octameric nucleosomes
Nature Structural and Molecular Biology, 2013 Nucleosomes with histone H3 replaced by CENP-A direct kinetochore assembly. CENP-A nucleosomes from human and Drosophila have been reported to have reduced heights as compared to canonical octameric H3 nucleosomes, thus suggesting a unique tetrameric ...
Colin J Fuller +2 more
exaly +2 more sources
Salt-induced structural changes in nucleosomes
Nucleic Acids Research, 1977 Nucleosomes and oligonucleosomes were prepared by digestion of human pla-cental nuclei with staphlococccal nuclease and fractionated by gel filtration chromatography.
C G Sahasrabuddhe +2 more
exaly +1 more source
A method for cryo-EM analysis of eukaryotic nucleosomes reconstituted in bacterial cells [PDF]
iScienceSummary: Conventional methods for preparing nucleosomes are time-consuming and technically demanding. In the present study, we extended the approach of generating nucleosomes in Escherichia coli by the co-expression of all four histones, allowing ...
Cheng-Han Ho +4 more
doaj +2 more sources
Tetrameric Structure of Centromeric Nucleosomes in Interphase Drosophila Cells
PLoS Biology, 2007 Centromeres, the specialized chromatin structures that are responsible for equal segregation of chromosomes at mitosis, are epigenetically maintained by a centromere-specific histone H3 variant (CenH3).
Yamini Dalal, Hongda Wang
exaly +2 more sources
Journal of Inflammation ResearchXudong Cui,1,* Tiewei Li,2,* Jingping Yang,3 Xiaojuan Li,2 Pengfei Xuan,3 Hongyan Wang3 1Respiratory and Critical Care Medicine Department, Inner Mongolia Baogang Hospital, Inner Mongolia Medical University, Hohhot, People’s Republic of China ...
Cui X +5 more
doaj +2 more sources
Pathogens, 2021 (1) Background: Hepatocellular carcinoma (HCC) is the most serious complication of chronic hepatitis B (CHB). Recently, the detection of circulating cell-free (cf) DNA and nucleosomes has found numerous applications in oncology.
Alkistis Papatheodoridi +4 more
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Breaking the aging epigenetic barrier
Frontiers in Cell and Developmental Biology, 2022 Aging is an inexorable event occurring universally for all organisms characterized by the progressive loss of cell function. However, less is known about the key events occurring inside the nucleus in the process of aging.
Sweta Sikder +3 more
doaj +1 more source
An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
eLife, 2023 In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between free/accessible and collapsed/DNA-bound states. The latter state is expected to impact histone N-termini availability to the epigenetic machinery. Notably, H3 tail acetylation (
Kanishk Jain +29 more
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Fine Chromatin-Driven Mechanism of Transcription Interference by Antisense Noncoding Transcription
Cell Reports, 2020 Summary: Eukaryotic genomes are almost entirely transcribed by RNA polymerase II. Consequently, the transcription of long noncoding RNAs often overlaps with coding gene promoters, triggering potential gene repression through a poorly characterized ...
Jatinder Kaur Gill +4 more
doaj +1 more source