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Replication-Coupled Chromatin Remodeling: An Overview of Disassembly and Assembly of Chromatin during Replication [PDF]
International Journal of Molecular Sciences, 2021 The doubling of genomic DNA during the S-phase of the cell cycle involves the global remodeling of chromatin at replication forks. The present review focuses on the eviction of nucleosomes in front of the replication forks to facilitate the passage of replication machinery and the mechanism of replication-coupled chromatin assembly behind the ...
Céline Duc, Christophe Thiriet
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The mechanism and consequences of chromatin assembly and disassembly [PDF]
Epigenetics & Chromatin, 2013 The Eukaryotic genome is packaged together with histone proteins to form the nucleoprotein structure called chromatin. This packaging of DNA into chromatin is critical to prevent inappropriate access to the DNA in order to enable the fundamental processes of the genome, such as gene expression, DNA repair and DNA replication, to be highly regulated ...
Jessica K. Tyler
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Chromatin gels are auxetic due to cooperative nucleosome assembly and disassembly dynamics
EPL (Europhysics Letters), 2017 We study "chromatin gels", model systems for chromatin, to theoretically predict the conditions, under which such gels show negative Poisson's ratios. A chromatin gel shows phase separation due to an instability arising from the disassembly of nucleosomes by RNA polymerases during transcription.
Tetsuya Yamamoto, Helmut Schießel
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Chromatin Assembly and Disassembly
The FASEB Journal, 2013 The eukaryotic genome is packaged together with histone proteins to form the nucleoprotein structure called chromatin. This packaging of DNA into chromatin is critical to prevent inappropriate access to the DNA in order to enable the fundamental processes of the genome, such as gene expression, DNA repair and DNA replication, to be highly regulated ...
Jessica K. Tyler
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Chromatin Assembly and Disassembly During Genomic Processes
The FASEB Journal, 2008 Chromatin assembly and disassembly has long been acknowledged to accompany the process of DNA replication. Accordingly, we previously discovered a key histone chaperone involved in the assembly of chromatin during DNA replication, termed Asf1 (Tyler et al., Nature 1999).
Jessica K Tyler +3 more
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PLoS Biology, 2014 At blocked replication forks, homologous recombination mediates the nascent strands to switch template in order to ensure replication restart, but faulty template switches underlie genome rearrangements in cancer cells and genomic disorders ...
Violena Pietrobon +6 more
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PBAF/cBAF reorganization on H3.3 chromatin regulates BMAL1 activity in the absence of circadian negative feedback [PDF]
Nature CommunicationsCircadian rhythms in gene expression are coincident with 24 hr dynamics in the recruitment of the core-clock transcription factor heterodimer CLOCK-BMAL1 to chromatin.
Dominika Letkova +5 more
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Nucleosome assembly and disassembly pathways in vitro.
PLoS ONE, 2022 Structural fluctuations of nucleosomes modulate the access to internal DNA in eukaryotic cells; clearly characterisation of this fundamental process is crucial to understanding gene regulation.
Akiko Hatakeyama +6 more
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Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes [PDF]
Diabetes & Metabolism Journal, 2023 Background Dysfunction of vascular endothelial cells (ECs) plays a central role in the pathogenesis of cardiovascular complications in diabetes. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) is a ...
Ju Wang +4 more
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Nucleosome Assembly and Disassembly in vitro Are Governed by Chemical Kinetic Principles
Frontiers in Cell and Developmental Biology, 2021 As the elementary unit of eukaryotic chromatin, nucleosomes in vivo are highly dynamic in many biological processes, such as DNA replication, repair, recombination, or transcription, to allow the necessary factors to gain access to their substrate.
Hongyu Zhao +17 more
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