Results 1 to 10 of about 18,637 (125)
PLoS Biology, 2014 At blocked replication forks, homologous recombination mediates the nascent strands to switch template in order to ensure replication restart, but faulty template switches underlie genome rearrangements in cancer cells and genomic disorders ...
Violena Pietrobon +6 more
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Replication-Coupled Chromatin Remodeling: An Overview of Disassembly and Assembly of Chromatin during Replication [PDF]
International Journal of Molecular Sciences, 2021 The doubling of genomic DNA during the S-phase of the cell cycle involves the global remodeling of chromatin at replication forks. The present review focuses on the eviction of nucleosomes in front of the replication forks to facilitate the passage of replication machinery and the mechanism of replication-coupled chromatin assembly behind the ...
Celine Duc +2 more
exaly +4 more sources
Regulation of Chromatin Assembly/Disassembly by Rtt109p, a Histone H3 Lys56-specific Acetyltransferase, in Vivo [PDF]
Journal of Biological Chemistry, 2010 Rtt109p, a histone acetyltransferase, associates with active genes and acetylates lysine 56 on histone H3 in Saccharomyces cerevisiae. However, the functional role of Rtt109p or H3 Lys(56) acetylation in chromatin assembly/disassembly (and hence gene expression) immediately switching transcription on or off has not been clearly elucidated in vivo. Here,
Geetha Durairaj +2 more
exaly +3 more sources
Chromatin gels are auxetic due to cooperative nucleosome assembly and disassembly dynamics
Europhysics Letters, 2017 We study "chromatin gels", model systems for chromatin, to theoretically predict the conditions, under which such gels show negative Poisson's ratios. A chromatin gel shows phase separation due to an instability arising from the disassembly of nucleosomes by RNA polymerases during transcription.
Tetsuya Yamamoto, Helmut Schießel
exaly +4 more sources
Nucleosome assembly and disassembly pathways in vitro.
PLoS ONE, 2022 Structural fluctuations of nucleosomes modulate the access to internal DNA in eukaryotic cells; clearly characterisation of this fundamental process is crucial to understanding gene regulation.
Akiko Hatakeyama +6 more
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Hyperglycemia-Suppressed SMARCA5 Disrupts Transcriptional Homeostasis to Facilitate Endothelial Dysfunction in Diabetes [PDF]
Diabetes & Metabolism Journal, 2023 Background Dysfunction of vascular endothelial cells (ECs) plays a central role in the pathogenesis of cardiovascular complications in diabetes. SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5) is a ...
Ju Wang +4 more
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Nucleosome Assembly and Disassembly in vitro Are Governed by Chemical Kinetic Principles
Frontiers in Cell and Developmental Biology, 2021 As the elementary unit of eukaryotic chromatin, nucleosomes in vivo are highly dynamic in many biological processes, such as DNA replication, repair, recombination, or transcription, to allow the necessary factors to gain access to their substrate.
Hongyu Zhao +17 more
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Effective dynamics of nucleosome configurations at the yeast PHO5 promoter
eLife, 2021 Chromatin dynamics are mediated by remodeling enzymes and play crucial roles in gene regulation, as established in a paradigmatic model, the Saccharomyces cerevisiae PHO5 promoter. However, effective nucleosome dynamics, that is, trajectories of promoter
Michael Roland Wolff +3 more
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Epigenetics & Chromatin, 2022 Nucleosome assembly proteins (NAPs) are histone chaperones that play a central role in facilitating chromatin assembly/disassembly which is of fundamental importance for DNA replication, gene expression regulation, and progression through the cell cycle.
Jasmita Gill, Anuj Kumar, Amit Sharma
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Nucleosome proteostasis and histone turnover
Frontiers in Molecular Biosciences, 2022 Maintenance of protein folding homeostasis, or proteostasis is critical for cell survival as well as for execution of cell type specific biological processes such as muscle cell contractility, neuronal synapse and memory formation, and cell transition ...
Adrian Arrieta +3 more
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