Results 1 to 10 of about 18,705 (160)
Nucleosome proteostasis and histone turnover
Frontiers in Molecular Biosciences, 2022 Maintenance of protein folding homeostasis, or proteostasis is critical for cell survival as well as for execution of cell type specific biological processes such as muscle cell contractility, neuronal synapse and memory formation, and cell transition ...
Adrian Arrieta +3 more
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The histone chaperone FACT modulates nucleosome structure by tethering its components
Life Science Alliance, 2018 The histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Tao Wang +5 more
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Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus
FEBS Open Bio, 2021 Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually just regarded as an apoptotic trigger.
Katiuska González‐Arzola +7 more
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FACT prevents the accumulation of free histones evicted from transcribed chromatin and a subsequent cell cycle delay in G1. [PDF]
PLoS Genetics, 2010 The FACT complex participates in chromatin assembly and disassembly during transcription elongation. The yeast mutants affected in the SPT16 gene, which encodes one of the FACT subunits, alter the expression of G1 cyclins and exhibit defects in the G1/S ...
Macarena Morillo-Huesca +9 more
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Chromatin Assembly and Disassembly During Genomic Processes
The FASEB Journal, 2008 Chromatin assembly and disassembly has long been acknowledged to accompany the process of DNA replication. Accordingly, we previously discovered a key histone chaperone involved in the assembly of chromatin during DNA replication, termed Asf1 (Tyler et al., Nature 1999).
Jessica K Tyler +3 more
openaire +1 more source
A coordinated interdependent protein circuitry stabilizes the kinetochore ensemble to protect CENP-A in the human pathogenic yeast Candida albicans. [PDF]
PLoS Genetics, 2012 Unlike most eukaryotes, a kinetochore is fully assembled early in the cell cycle in budding yeasts Saccharomyces cerevisiae and Candida albicans. These kinetochores are clustered together throughout the cell cycle.
Jitendra Thakur, Kaustuv Sanyal
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Quantitative analysis of the transcription control mechanism
Molecular Systems Biology, 2010 Gene transcription requires a sequence of promoter state transitions, including chromatin remodeling, assembly of the transcription machinery, and clearance of the promoter by RNA polymerase.
Changhui Mao +6 more
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The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
eLife, 2016 The cell achieves DNA double-strand break (DSB) repair in the context of chromatin structure. However, the mechanisms used to expose DSBs to the repair machinery and to restore the chromatin organization after repair remain elusive.
Xuan Li, Jessica K Tyler
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Histone deposition promotes recombination-dependent replication at arrested forks.
PLoS Genetics, 2019 Replication stress poses a serious threat to genome stability. Recombination-Dependent-Replication (RDR) promotes DNA synthesis resumption from arrested forks.
Julien Hardy +9 more
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