The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo. [PDF]
PLoS Genetics, 2023 Histones are essential for chromatin packaging, and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited.
Reyhaneh Tirgar +3 more
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Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of nucleosome arrays [PDF]
Nature CommunicationsChromatin condensation is dynamically regulated throughout the cell cycle and plays key roles in modulating gene accessibility. The DNA-histone dynamics in the nucleosome are central to the regulation mechanisms of chromatin condensation, which remain ...
Jia Gao +4 more
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Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis [PDF]
Nature Communications, 2022 Histone chaperones and chromatin remodelers control nucleosome dynamics. Here the authors show that the Arabidopsis ASF1 chaperone primarily supplies histone variants to the HIRA complex to ensure proper epigenetic gene regulation.
Zhenhui Zhong +14 more
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ATAD2 mediates chromatin-bound histone chaperone turnover [PDF]
eLifeATAD2, a conserved protein which is predominantly expressed in embryonic stem (ES) cells and spermatogenic cells, emerges as a crucial regulator of chromatin plasticity. Our previous parallel studies conducted in both ES cells and S.
Ariadni Liakopoulou +13 more
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The histone chaperone function of Daxx is dispensable for embryonic development [PDF]
Cell Death and Disease, 2023 Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including centromeres ...
Chang Sun +6 more
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Histone Chaperone Nrp1 Mutation Affects the Acetylation of H3K56 in Tetrahymena thermophila [PDF]
Cells, 2022 Histone modification and nucleosome assembly are mainly regulated by various histone-modifying enzymes and chaperones. The roles of histone-modification enzymes have been well analyzed, but the molecular mechanism of histone chaperones in histone ...
Yinjie Lian +4 more
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Histone chaperone-mediated nucleosome assembly process. [PDF]
PLoS ONE, 2015 A huge amount of information is stored in genomic DNA and this stored information resides inside the nucleus with the aid of chromosomal condensation factors.
Hsiu-Fang Fan +4 more
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TSPY-like 2, Beyond the Histone Chaperone Role [PDF]
BiomoleculesChromatin is a dynamic cellular structure basically constituted by nucleosomes, which consist of a DNA sequence wrapped around an octameric histones core.
Emanuele Bonenti +3 more
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A potential histone-chaperone activity for the MIER1 histone deacetylase complex. [PDF]
Nucleic Acids Res, 2023 Abstract Histone deacetylases 1 and 2 (HDAC1/2) serve as the catalytic subunit of six distinct families of nuclear complexes. These complexes repress gene transcription through removing acetyl groups from lysine residues in histone tails.
Wang S +7 more
europepmc +4 more sources
Structure of the Hir histone chaperone complex. [PDF]
Mol CellThe evolutionarily conserved HIRA/Hir histone chaperone complex and ASF1a/Asf1 co-chaperone cooperate to deposit histone (H3/H4)2 tetramers on DNA for replication-independent chromatin assembly. The molecular architecture of the HIRA/Hir complex and its mode of histone deposition have remained unknown.
Kim HJ +11 more
europepmc +3 more sources