ATAD2 mediates chromatin-bound histone chaperone turnover [PDF]
eLifeATAD2, a conserved protein which is predominantly expressed in embryonic stem (ES) cells and spermatogenic cells, emerges as a crucial regulator of chromatin plasticity. Our previous parallel studies conducted in both ES cells and S.
Ariadni Liakopoulou +13 more
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DAXX adds a de novo H3.3K9me3 deposition pathway to the histone chaperone network [PDF]
Molecular Cell, 2023 A multitude of histone chaperones are required to support histones from their biosynthesis until DNA deposition. They cooperate through the formation of histone co-chaperone complexes, but the crosstalk between nucleosome assembly pathways remains ...
Moritz Völker-Albert
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Structure of the Hir histone chaperone complex [PDF]
Molecular CellThe evolutionarily conserved HIRA/Hir histone chaperone complex and ASF1a/Asf1 co-chaperone cooperate to deposit histone (H3/H4)2 tetramers on DNA for replication-independent chromatin assembly. The molecular architecture of the HIRA/Hir complex and its mode of histone deposition have remained unknown.
M Daniel Ricketts
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The histone chaperone NASP maintains H3-H4 reservoirs in the early Drosophila embryo. [PDF]
PLoS Genetics, 2023 Histones are essential for chromatin packaging, and histone supply must be tightly regulated as excess histones are toxic. To drive the rapid cell cycles of the early embryo, however, excess histones are maternally deposited.
Reyhaneh Tirgar +3 more
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Roles of histone chaperone Nap1 and histone acetylation in regulating phase-separation of nucleosome arrays [PDF]
Nature CommunicationsChromatin condensation is dynamically regulated throughout the cell cycle and plays key roles in modulating gene accessibility. The DNA-histone dynamics in the nucleosome are central to the regulation mechanisms of chromatin condensation, which remain ...
Jia Gao +4 more
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Histone chaperone ASF1 mediates H3.3-H4 deposition in Arabidopsis [PDF]
Nature Communications, 2022 Histone chaperones and chromatin remodelers control nucleosome dynamics. Here the authors show that the Arabidopsis ASF1 chaperone primarily supplies histone variants to the HIRA complex to ensure proper epigenetic gene regulation.
Zhenhui Zhong +14 more
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UBR7 acts as a histone chaperone for post‐nucleosomal histone H3 [PDF]
EMBO Journal, 2021 Histone chaperones modulate the stability of histones beginning from histone synthesis, through incorporation into DNA, and during recycling during transcription and replication. Following histone removal from DNA, chaperones regulate histone storage and degradation.
Alexander S Lee +2 more
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Dynamic Activity of Histone H3-Specific Chaperone Complexes in Oncogenesis
Frontiers in Oncology, 2022 Canonical histone H3.1 and variant H3.3 deposit at different sites of the chromatin via distinct histone chaperones. Histone H3.1 relies on chaperone CAF-1 to mediate replication-dependent nucleosome assembly during S-phase, while H3.3 variant is ...
Qiao Yi Chen, Wen Ting
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The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states [PDF]
Cell Reports, 2021 Summary: Heterochromatin formation requires three distinct steps: nucleation, self-propagation (spreading) along the chromosome, and faithful maintenance after each replication cycle.
Magdalena Murawska +7 more
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The histone chaperone function of Daxx is dispensable for embryonic development [PDF]
Cell Death and Disease, 2023 Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form a protein complex that deposits H3.3 into heterochromatic regions of the genome, including centromeres ...
Chang Sun +6 more
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