DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network [PDF]
Molecular Cell, 2021 From biosynthesis to assembly into nucleosomes, histones are handed through a cascade of histone chaperones, which shield histones from non-specific interactions. Whether mechanisms exist to safeguard the histone fold during histone chaperone handover events or to release trapped intermediates is unclear.
Hammond, Colin M. +13 more
openaire +5 more sources
Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast
Nature Communications, 2018 Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions.
Soyun Lee +9 more
doaj +1 more source
Histone Chaperones: Modulators of Chromatin Marks [PDF]
Molecular Cell, 2011 The many factors that control chromatin biology play key roles in essential nuclear functions like transcription, DNA damage response and repair, recombination, and replication and are critical for proper cell-cycle progression, stem cell renewal, differentiation, and development. These players belong to four broad classes: histone modifiers, chromatin
Avvakumov, Nikita +2 more
openaire +2 more sources
Histone Hypervariants H2A.Z.1 and H2A.Z.2 Play Independent and Context-Specific Roles in Neuronal Activity-Induced Transcription of Arc/Arg3.1 and Other Immediate Early Genes. [PDF]
, 2017 The histone variant H2A.Z is an essential and conserved regulator of eukaryotic gene transcription. However, the exact role of this histone in the transcriptional process remains perplexing.
Bailey, Emma R +7 more
core +1 more source
The yeast histone chaperone hif1p functions with RNA in nucleosome assembly. [PDF]
PLoS ONE, 2014 Hif1p is an H3/H4-specific histone chaperone that associates with the nuclear form of the Hat1p/Hat2p complex (NuB4 complex) in the yeast Saccharomyces cerevisiae. While not capable of depositing histones onto DNA on its own, Hif1p can act in conjunction
Amy R Knapp, Huanyu Wang, Mark R Parthun
doaj +1 more source
The histone variant H3.3 regulates the transcription of the hepatitis B virus
Annals of Hepatology, 2021 Introduction and Objectives: About 250 million people around the world are chronically infected with the hepatitis B virus (HBV). Those people are at risk of developing hepatocellular carcinoma.
Francisca Alvarez-Astudillo +5 more
doaj +1 more source
Hepatitis C virus NS5A targets the nucleosome assembly protein NAP1L1 to control the innate cellular response [PDF]
, 2017 Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular ...
Cesarec, Mia +5 more
core +1 more source
Histone chaperones, histone acetylation, and the fluidity of the chromogenome [PDF]
Journal of Cellular Physiology, 2010 AbstractThe “chromogenome” is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post‐translational acetylation of histones, and modulation of the chromogenome.
Jeffrey C, Hansen +3 more
openaire +2 more sources
A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation in Xenopus
Cell Reports, 2012 Discovering how histone variants that mark distinct chromatin regions affect a developmental program is a major challenge in the epigenetics field. To assess the importance of the H3.3 histone variant and its dedicated histone chaperone HIRA, we used an ...
Emmanuelle Szenker +2 more
doaj +1 more source
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis [PDF]
The EMBO Journal, 2013 Histone chaperones affect chromatin structure and gene expression through interaction with histones and RNA polymerase II (PolII). Here, we report that the histone chaperone Spt6 counteracts H3K27me3, an epigenetic mark deposited by the Polycomb Repressive Complex 2 (PRC2) and associated with transcriptional repression.
A Hongjun, Wang +8 more
openaire +2 more sources