Results 31 to 40 of about 31,898 (266)

Dot1 regulates nucleosome dynamics by its inherent histone chaperone activity in yeast

Nature Communications, 2018
Dot1 is an evolutionarily conserved enzyme, responsible for histone H3K79 methylation in most eukaryotes. Here authors show that, in yeast, Dot1p has histone chaperone activity and regulates nucleosome dynamics via histone exchange in transcribed regions.
Soyun Lee, Seunghee Oh, Kwiwan Jeong, Hyelim Jo, Yoonjung Choi, Hogyu David Seo, Minhoo Kim, Joonho Choe, Chang Seob Kwon, Daeyoup Lee   +9 more
doaj   +2 more sources

The Histone Chaperone Network Is Highly Conserved in Physarum polycephalum. [PDF]

Int J Mol Sci, 2023
The nucleosome is composed of histones and DNA. Prior to their deposition on chromatin, histones are shielded by specialized and diverse proteins known as histone chaperones.
Poulet A, Rousselot E, Téletchéa S, Noirot C, Jacob Y, van Wolfswinkel J, Thiriet C, Duc C.   +7 more
europepmc   +2 more sources

The effects of the histone chaperone and histone modifications on nucleosome structure [PDF]

, 2016
The nucleosome, composed of 147-bp DNA and a histone octamer, is the basic unit of chromatin in eukaryotes, which is considered as a barrier for all DNA dependent processes. Understanding how nucleosome structure is regulated provides new insights into pivotal cellular processes.
Wang, Tao, author, Luger, Karolin, advisor, Stargell, Laurie, committee member, Yao, Tingting, committee member, Williams, Robert M., committee member   +4 more
openaire   +2 more sources

Histone Variants and Their Chaperones: An Emerging Epigenetic Mechanism in Neurodevelopment and Neurodevelopmental Disorders

Journal of Integrative Neuroscience, 2023
Neurodevelopment is a highly regulated process that relies on the precise regulation of gene expression. Numerous epigenetic mechanisms contribute and cooperate to ensure the proper execution of developmental gene expression programs.
Karanveer S Johal, Manjinder S Cheema, Gilda Stefanelli   +2 more
doaj   +1 more source

Histones, histone chaperones and nucleosome assembly [PDF]

Protein & Cell, 2010
Chromatin structure governs a number of cellular processes including DNA replication, transcription, and DNA repair. During DNA replication, chromatin structure including the basic repeating unit of chromatin, the nucleosome, is temporarily disrupted, and then reformed immediately after the passage of the replication fork.
Rebecca J, Burgess, Zhiguo, Zhang
openaire   +2 more sources

The Saccharomyces cerevisiae histone chaperone Rtt106 mediates the cell cycle recruitment of SWI/SNF and RSC to the HIR-dependent histone genes. [PDF]

PLoS ONE, 2011
In Saccharomyces cerevisiae, three out of the four histone gene pairs (HTA1-HTB1, HHT1-HHF1, and HHT2-HHF2) are regulated by the HIR co-repressor complex.
Monica E Ferreira, Kacie Flaherty, Philippe Prochasson   +2 more
doaj   +1 more source

The histone shuffle: histone chaperones in an energetic dance [PDF]

Trends in Biochemical Sciences, 2010
Our genetic information is tightly packaged into a rather ingenious nucleoprotein complex called chromatin in a manner that enables it to be rapidly accessed during genomic processes. Formation of the nucleosome, which is the fundamental unit of chromatin, occurs via a stepwise process that is reversed to enable the disassembly of nucleosomes.
Chandrima, Das, Jessica K, Tyler, Mair E A, Churchill   +2 more
openaire   +2 more sources

Histone chaperones, histone acetylation, and the fluidity of the chromogenome [PDF]

Journal of Cellular Physiology, 2010
AbstractThe “chromogenome” is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post‐translational acetylation of histones, and modulation of the chromogenome.
Jeffrey C, Hansen, Jennifer K, Nyborg, Karolin, Luger, Laurie A, Stargell   +3 more
openaire   +2 more sources

Identification and Characterization of HIRIP3 as a Histone H2A Chaperone

Cells
HIRIP3 is a mammalian protein homologous to the yeast H2A.Z deposition chaperone Chz1. However, the structural basis underlying Chz’s binding preference for H2A.Z over H2A, as well as the mechanism through which Chz1 modulates histone deposition or ...
Maria Ignatyeva, Abdul Kareem Mohideen Patel, Abdulkhaleg Ibrahim, Raed S. Albiheyri, Ali T. Zari, Ahmed Bahieldin, Christian Bronner, Jamal S. M. Sabir, Ali Hamiche   +8 more
doaj   +2 more sources

Histone chaperones in nucleosome eviction and histone exchange [PDF]

Current Opinion in Structural Biology, 2008
The recent two years have led to the realization that histone chaperones contribute to the delicate balance between nucleosome assembly and re-assembly during transcription, and may in fact be involved as much in histone eviction as they are in chromatin assembly.
Young-Jun, Park, Karolin, Luger
openaire   +2 more sources