Results 31 to 40 of about 31,902 (257)
Towards a mechanism for histone chaperones [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2012 Histone chaperones can be broadly defined as histone-binding proteins that influence chromatin dynamics in an ATP-independent manner. Their existence reflects the importance of chromatin homeostasis and the unique and unusual biochemistry of the histone proteins.
Elsässer SJ, D'Arcy S
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Advanced Science, 2023 Chromatin homeostasis mediates essential processes in eukaryotes, where histone chaperones have emerged as major regulatory factors during DNA replication, repair, and transcription.
Pedro Buzón +5 more
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Histone transfer among chaperones [PDF]
Biochemical Society Transactions, 2012 The eukaryotic processes of nucleosome assembly and disassembly govern chromatin dynamics, in which histones exchange in a highly regulated manner to promote genome accessibility for all DNA-dependent processes. This regulation is partly carried out by histone chaperones, which serve multifaceted roles in co-ordinating the interactions of histone ...
Wallace H, Liu, Mair E A, Churchill
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Histone chaperones regulate histone exchange during transcription [PDF]
The EMBO Journal, 2007 Transcription by RNA polymerase II is accompanied by dynamic changes in chromatin, including the eviction/deposition of nucleosomes or the covalent modification of histone subunits. This study examined the role of the histone H3/H4 chaperones, Asf1 and HIR, in histone mobility during transcription, with particular focus on the histone exchange pathway,
Hye-Jin, Kim +4 more
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Chaperoning histones at the DNA repair dance
DNA Repair, 2021 Unlike all other biological molecules that are degraded and replaced if damaged, DNA must be repaired as chromosomes cannot be replaced. Indeed, DNA endures a wide variety of structural damage that need to be repaired accurately to maintain genomic stability and proper functioning of cells and to prevent mutation leading to disease.
Ujani Chakraborty +2 more
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Optimal Anchoring of a Urea-based Foldamer Inhibitor of ASF1 Histone Chaperone Through Backbone Plasticity [PDF]
, 2020 Sequence-specific oligomers with predictable folding patterns, i.e. foldamers provide new opportunities to mimic α-helical peptides and design inhibitors of protein-protein interactions.
Marie E., Perrin +11 more
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Cell Reports, 2020 Summary: HIRA is a histone chaperone that deposits the histone variant H3.3 in transcriptionally active genes. In DiGeorge syndromes, a DNA stretch encompassing HIRA is deleted.
Chao Chen +9 more
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ATAD2 controls chromatin-bound HIRA turnover
Life Science Alliance, 2021 Parallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor. Taking advantage of the evolutionary conserved nature of ATAD2, we report here a series of parallel functional ...
Tao Wang +17 more
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Simplified Method for Rapid Purification of Soluble Histones
Croatica Chemica Acta, 2016 Functional and structural studies of histone-chaperone complexes, nucleosome modifications, their interactions with remodelers and regulatory proteins rely on obtaining recombinant histones from bacteria.
Nives Ivić +3 more
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Nature Communications, 2021 How gene expression reactivation is promoted following DNA damage is not yet clear. Here, the authors identify a role for the human histone chaperone complex HIRA in transcription restart following UV damage independently of its function in new H3.3 ...
Déborah Bouvier +5 more
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